2016
DOI: 10.1016/j.bjp.2015.11.001
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Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae

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Cited by 7 publications
(5 citation statements)
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“…This is evident from our toxicity study that did not demonstrate any neurotoxicity at the highest dose of 400 mg/kg. The lack of dose–response effects could also be due to saturation of receptors at higher concentrations where a similar observation has been reported in other studies (Lima et al, 2016; Manalo et al, 2017). In the present study, it is unclear as to whether the observed effects were produced by the major phytoconstituents of the plant or as a result of a combined effects of various phytochemicals present in the extract.…”
Section: Discussionsupporting
confidence: 81%
“…This is evident from our toxicity study that did not demonstrate any neurotoxicity at the highest dose of 400 mg/kg. The lack of dose–response effects could also be due to saturation of receptors at higher concentrations where a similar observation has been reported in other studies (Lima et al, 2016; Manalo et al, 2017). In the present study, it is unclear as to whether the observed effects were produced by the major phytoconstituents of the plant or as a result of a combined effects of various phytochemicals present in the extract.…”
Section: Discussionsupporting
confidence: 81%
“…Previous studies demonstrated that kaempherol acting on smooth muscle in vascular rings isolated from rat aorta produces vasorelaxant effects . Recently, we conducted the toxicological and standardization studies of the leaf extract of H. tiubae and demonstrated that the extract is not toxic at dose of 2.000 mg/kg .…”
Section: Introductionmentioning
confidence: 96%
“…Malheiros et al (2017) [ 21 ], using C. speciosa ethanolic extract on human lymphocytes, demonstrated a high toxicity but with higher concentration than the ones chosen in our study. Lima et al (2016) [ 38 ] demonstrated that the hydroalcoholic extract of Herisantia tiubae K. Schum. (Malvaceae) at low concentrations (6.25 to 50 μg/mL) had no toxic effect on RAW 264.7 cells; however, concentrations higher than 100 μg/mL significantly reduced the cell viability.…”
Section: Discussionmentioning
confidence: 99%