Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

Wu, Guan-James; Shiu, Shiau-Mei; Hsieh, Meng-Chen; Tsai, Guo-Jane

doi:10.1016/j.foodhyd.2015.01.019

Cited by 125 publications

(71 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…43 Furthermore, Wu et al showed that total extracts from red, green and brown algae have pronounced anti-inflammatory activity manifested as a high NO inhibitory effect. 44 In addition, a recent study showed that carrageenans do not stimulate cells to produce pro-inflammatory cytokines, 45 as also seen in our in vivo experimental model. These results are correlated with data shown earlier by us that, for example, j-carrageenan exhibits a protective effect on acid-induced colitis in mice in terms of morphological and biochemical parameters, 24 and that the same carrageenan sample contributes to increasing survival and mean life span of mice with experimental bacterial endotoxemia.…”

Section: Discussionsupporting

confidence: 71%

“…It has been shown that sulfated polysaccharide isolated from the brown alga Sargassum hemiphyllum has a protective effect and significantly reduces the secretion of pro‐inflammatory cytokines, including IL‐1β, IL‐6 and TNF‐α, as well as NO in mouse macrophages activated by LPS . Furthermore, Wu et al showed that total extracts from red, green and brown algae have pronounced anti‐inflammatory activity manifested as a high NO inhibitory effect . In addition, a recent study showed that carrageenans do not stimulate cells to produce pro‐inflammatory cytokines, as also seen in our in vivo experimental model.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Influence of carrageenan on cytokine production and cellular activity of mouse peritoneal macrophages and its effect on experimental endotoxemia

Kalitnik¹,

Karetin

Kravchenko

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

The in vivo effect of κ/β-carrageenan isolated from the red alga Tichocarpus crinitus on cytokine synthesis and cellular activity of murine peritoneal macrophages and also the protective effect of polysaccharides in LPS-induced endotoxemia in mice was studied. It was established that κ/β-carrageenan given orally at a dose of 100 mg/kg stimulates the induction of anti-inflammatory cytokines (IL-10) in mouse blood cells by more than 2.5-fold compared with control, with no effect on pro-inflammatory cytokine (TNF-α) production. Pretreating mice with carrageenan once a day before injecting LPS increased the levels of IL-10 by 2.5-fold and reduced TNF-α production by 2-fold compared with control. So, κ/β-carrageenan alone and in combination with LPS enhanced the cellular activity and mobility of peritoneal macrophages by increasing cell adhesion and migration compared with control. LPS activated cells intensively, sometimes resulting in their destruction by necrosis; carrageenan pretreatment reduced the excessive inflammatory cell activation caused by LPS. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1549-1557, 2017.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 95%

Influence of carrageenan on cytokine production and cellular activity of mouse peritoneal macrophages and its effect on experimental endotoxemia

Kalitnik¹,

Karetin

Kravchenko

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…APS such as alginate, extracted from brown seaweed, as well as agar and carrageenan from red seaweed, are used by the food industry in numerous food products and beverages adding up to a market value of $10.000 per ton of dry seaweed [101]. As it was shown, alginate and other brown algae sulfated polysaccharides such as fucoidan and laminarin are also being researched for their anti-tumor [102], anti-microbial [103], immunostimulatory [104] and anti-inflamatory [105] activity. In addition, new advances are being made in the research of their drug delivery, tissue engineering and skin rejuvenating properties.…”

Section: Brown Algae Sulfated Polysaccharides As Drug Delivery Systemmentioning

confidence: 99%

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

View full text Add to dashboard Cite

Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.(APS) is determined by algae species however it is also influenced by other factors causing inter-species variation, e.g., growth location and harvesting season [8]. Vast structural variation between the APS therefore presents a challenge in terms of pre-treatments application, extraction techniques and optimization, characterization of isolated fractions and determination of their biological properties.Chemical structure and yield of APS isolated from marine macroalgae by conventional extraction (CE) techniques can be affected by various experimental conditions (pH, time, temperature, pressure, particle size, solvent, sample to solvent ratio, agitation speed etc.). In addition, different advanced techniques such as microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), pressurized liquid extraction (PLE), enzyme-assisted extractions (EAE) are assessed and applied for APS extraction [9][10][11].In general, the chemical structure of polysaccharides determines its physical, chemical and biochemical properties as well as its biological activities [12]. Several studies have reported that their biological activity is strongly associated with their chemical structure [9]. Due to very complex mechanisms that are affected by many factors, the correlation between polysaccharide structure and biological activity is still not sufficiently clarified.In order to improve isolation of APS, pre-treatments are usually applied to the algal biomass prior to the extraction process with the two aims: (i) to prevent co-extraction of interfering bioactive compounds with similar solubility; and (ii) to disrupt cell walls and improve mass transfer of APS into extraction solvent. The first type of pre-treatments is therefore used to remove compounds which are highly bound to the APS such as proteins, phenols and lipids, as well as mannitol and chlorophyll [13]. For that purpose, the application of various pr...

show abstract

“…; Dore et al, 2013;Huang et al, 2016;Roohinejad et al, 2016;Sweeney et al, 2012;Wijesekara et al, 2011). Table 4 summarised antioxidant, anticancer, anticoagulant and antiinflammatory activities which are among the most widely studied properties of macroalgal derived fucoidan and laminarin in recent times (Cong et al, 2016;Hifney et al, 2016;Wu, Shiu, Hsieh, & Tsai, 2016).…”

Section: Biological Activity and Potential Health Applications Of Macmentioning

confidence: 99%

Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification

García‐Vaquero

Rajauria

O’Doherty

et al. 2017

Food Research International

274

166

View full text Add to dashboard Cite

show abstract

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

Cited by 125 publications

References 48 publications

Influence of carrageenan on cytokine production and cellular activity of mouse peritoneal macrophages and its effect on experimental endotoxemia

Influence of carrageenan on cytokine production and cellular activity of mouse peritoneal macrophages and its effect on experimental endotoxemia

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification

Contact Info

Product

Resources

About