Anti-inflammatory activity of an alkaloid fromSolanum trilobatumon acute and chronic inflammation models

Abstract

The solasodine isolated from Solanum trilobatum has been examined for possible anti-inflammatory activity in acute and chronic inflammatory animal models. Solasodine (5, 30 and 75 mg kg⁻¹) exerted statistically significant and dose-dependent anti-inflammatory activity in carrageenan-induced rat paw oedema, which was similar to that of indomethacin (10 mg kg⁻¹), a known anti-inflammatory agent. At the dose of 75 mg kg⁻¹, solasodine inhibited the arachidonic acid-elicited rat paw oedema 1 h after arachidonic acid challenge. Topical application of solasodine significantly inhibited the ear inflammation induced by multiple applications of tetradecanoyl-phorbol 13-acetate. It also suppressed the volume of exudates, total leucocytes and amount of neutrophil migration into the rat pleural cavity. Administration of solasodine at a dose of 75 mg kg⁻¹ significantly inhibited the adjuvant-induced rat paw oedema. These results suggest that solasodine exerts anti-inflammatory activity, at least partly through the inhibition of cyclooxygenase and 5-lipoxygenase pathways.

Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain

“…The profound antinociceptive effect of MSS at 400 mg/kg dose in acetic acid-induced writhing test, therefore, implies that MSS may be involved in the inhibition of inflammatory mediators like cyclooxygenase, lipoxygenase and others which results in the interruption of signal transduction in primary afferent nociceptors. Solasodine which have already been shown antinociceptive, antiinflammatory and CNS depressant activity may play important role in SS's antinociceptive effect along with other phytochemicals (Basu and Lahiri, 1997;Pandurangan et al, 2010;Pandurangan et al, 2011;Chauhan et al, 2011).The results of the present study underpin the preliminary basis of traditional use of S. sisymbriifolium in some painful conditions. It also presents the possibility of inhibition of inflammatory mediators as well as modulation of opioid system by compounds present in MSS.…”

“…Phytochemical analyses confirmed isolation of a number of pharmacologically active compounds from the plant including solamine, solasodiene and solasodine (Mazumdar, 1984), neolignan, designated as sisymbrifolin, and carpesterol together with β-sitosterol and its β-D-glucoside, cuscohygrine, (Evans and Somanabandhu, 1980;Ferro et al, 2005), solacaproine, solamargine, and β-solamarine (Ferro et al, 2005) and isonuatigenin-3-O-β-solatriose (Ibarrola et al, 2000). Solasodine, a major alkaloid, isolated from the plant has demonstrated variety of biological activities including antifungal (Kusano et al, 1987), cytotoxic (Nakamura et al, 1996), hepatoprotective (Lin et al, 1988), antinociceptive (Basu and Lahiri, 1977;Pandurangan et al, 2010), anti-inflammatory (Pandurangan et al, 2011), anticonvulsant, CNS depressant (Chauhan et al, 2011) and antiatherosclerotic activity (Dixit et al, 1992). Solasodine is effective in skin tumor treatment (Cham et al, 1987;Cham et al, 1991).…”

In Vitroantioxidative and anti-inflammatory activities of the ethanol extract of eggplant (Solanum melongena)stalks in macrophage RAW 264.7 cells

“…Although the EtOAc and BuOH extracts fractions contained high levels of phenols accompanied by substantial free-radical scavenging activities, they exerted poor antiinflammatory activities in inhibiting the production of COX-2 and PGE 2 as well as NO and pro-inflammatory cytokines. In contrast, the hexane and DCM fractions were the most active for these anti-inflammatory parameters despite low levels of phenols, indicating the presence of other compounds with anti-inflammatory activities, such as solasodine and lignanamides (Emmanuel, Ignacimuthu, Perumalsamy, & Amalraj, 2006;Pandurangan, Khosa, & Hemalatha, 2011;Sun et al, 2014).…”

Solanidane and iminosolanidane alkaloids from Solanum campaniforme

“…Plants belonging to the genus Solanum (Solanaceae) have been intensively investigated in terms of their chemical and/or biological properties (Lu et al, 2011;Chauhan et al, 2011;Silva, 2008;Pandurangan et al, 2010Pandurangan et al, , 2011. In this context, several reviews have also been published (Li et al, 2011;Milner et al, 2011;Wang et al, 2011).…”