Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis

Thomet, Olivier A. R.; Schapowal, Andreas; Heinisch, Isabelle; Wiesmann, Ulrich; Simon, Hans‐Uwe

doi:10.1016/s1567-5769(02)00046-2

Cited by 67 publications

(44 citation statements)

References 35 publications

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“…Thomet et al conducted a small clinical study on the efficacy of Petasites hybridus tablets in the treatment of allergic rhinitis symptoms [57]. Patients suffering from allergic rhinitis received two tablets of butterbur three times per day for 1 week.…”

Section: Leukotriene Inhibitorsmentioning

confidence: 99%

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

Kulka¹

2009

CTMC

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Abstract:The impact of natural products on human health has been enormous, and the study of natural products continues to influence research in the fields of chemistry, biology, and ecology. Historically, the majority of our medicines originate from natural products and their synthetic derivatives, many of which have taught us valuable lessons about biology. While advances in synthetic and combinatorial chemistry have given rise to notable successes in the development of new drugs, the perceived value of natural products in the treatment of allergic disease has yet to be fully explored. The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. Cells of the immune system may interact in a cell-cell manner and may also respond to intercellular messages including hormones, cytokines, and effector molecules produced by various cells. These effector molecules include histamine, kinins, leukotrienes, prostaglandins, and serotonin. The immune system can be modified by diet, pharmacologic agents, environmental pollutants, and naturally occurring food chemicals, such as vitamins and flavonoids. Allergic inflammation is mediated by several types of immune cells all of which can be effected by these naturally occurring bioactive compounds but this review will focus on mast cells and their mediators since these cells are the focal point of allergic reactions such as allergic rhinitis. The molecular mechanisms and scientific validity of some herbal remedies currently used clinically in the treatment of allergic rhinitis will be explored.

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Section: Leukotriene Inhibitorsmentioning

confidence: 99%

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

Kulka¹

2009

CTMC

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“…To determine the in vivo relevance of the in vitro investigations with the butterbur extract, an open clinical study in patients with allergic rhinitis has been performed using P. hybrides extract tablets [34]. The study design included six visits in 5 days in which clinical assessments were made and the clinical material collected.…”

Section: Clinical Investigationsmentioning

confidence: 99%

“…In clinical trials, extracts of butterbur have been suggested as a considerable alternative to common therapies applied in patients suffering from allergic disorders [32, 33, 34]. Here, we review our current understanding of how petasins and extracts of butterbur prevent synthesis and release of inflammatory mediators as well as results of two clinical studies carried out with allergic rhinitis patients.…”

Section: Introductionmentioning

confidence: 99%

Petasins in the Treatment of Allergic Diseases: Results of Preclinical and Clinical Studies

Thomet

Simon

2002

Int Arch Allergy Immunol

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Plant extracts are causing an increased interest in the treatment of many chronic diseases, including asthma and other allergic diseases. Several laboratories characterized petasins (petasin, isopetasin, and neopetasin) isolated from extracts of butterbur (Petasites hybridus) as pharmacologically active components, which inhibit leukotriene synthesis in leukocytes. The molecular mechanisms by which petasins abrogate inflammatory effector cell functions have, at least partially, been identified. In vitro studies revealed that petasins may have several intracellular targets and this may depend on the stereoisomer used. In an open clinical trial in patients suffering from allergic rhinitis, a reduction of leukotriene and histamine levels in nasal fluids was associated with the butterbur extract administration. To better evaluate the clinical value in this particular allergic disease, the clinical efficacy of the drug was compared with an established antihistamine treatment scheme in a double-blind study; no significant difference was observed between the two treatment groups. In this article, we critically review recently published work and summarize the current stage in the pharmacological characterization of butterbur extracts.

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“…Allergic rhinitis is a common allergic disease in industrialized nations, characterized by sneezing, water rhinorrhea, itching in the nose, eyes, and palate, and nasal congestion (1). Recently, the incidence of both perennial (2)(3)(4)(5) and seasonal allergic rhinitis (6-10) has been increasing worldwide.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen

Kobayashi

Tanabe²

2006

Int J Mol Med

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Abstract. The anti-allergic activity of the 50% methanol extract of Citrus unshiu powder (MEC) was examined. Fifty percent methanol extract of MEC powder showed potent inhibitory activity against histamine release from basophils of patients suffering from seasonal allergic rhinitis to ceder pollen. To examine this anti-allergic mechanism in detail, we next used rat basophlilic leukemia RBL-2H3 cells. MEC significantly inhibited IgE-induced histamine and ß-hexosaminidase release from RBL-2H3 cells. Since MEC contains a variety of flavonoids, we selected nobiletin, hesperetin, and hesperidin (hesperetin glycoside) as representative compounds, and further evaluated these inhibitory activities. Among the flavonoids tested, hesperetin was the most potent, while hesperidin had far less, if any, inhibitory activity. The mechanism by which flavonoids inhibited the degranulation process was then examined. As a result, hesperetin and nobiletin suppressed the phosphorylation of Akt-1, direct downstream effector of phosphatidylinositol 3-kinase (PI3-K). Thus, it was assumed that these flavonoids suppressed IgEmediated stimulation of basophils through PI3-K pathway and that proper intake of Citrus unshiu would be favorable for managing seasonal allergic rhinitis to ceder pollen.

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Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis

Cited by 67 publications

References 35 publications

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

Petasins in the Treatment of Allergic Diseases: Results of Preclinical and Clinical Studies

Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen

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