Anti-inflammatory activity of Anthemis tricolor Boiss

Abstract

A b s t r a c t Introduction: Traditionally, Anthemis genus has been used for the treatment of gastrointestinal disorders, haemorrhoid and stomach ache in Europe. There are several in-vitro and in-vivo studies that showed the pharmacological properties of Anthemis species such as antibacterial, anti-inflammatory, antiedemic and hepatoprotective properties. Aim: Our study referred to the model of inflammation formed in rats; we aimed to evaluate anti-inflammatory properties of A. tricolor extracts. Material and methods: Five different extracts of A. tricolor were tested against the negative control and 2 different topical corticosteroids (betamethasone and hydrocortisone); n-hexane and sesquiterpene extracts of A. tricolor Bois showed significantly reduced erythema compared to the negative control. Results: Only n-hexane and sesquiterpene extracts of A. tricolor have the anti-inflammatory effect. Conclusions: This is the first report on anti-inflammatory activity of A. tricolor and we showed an anti-inflammatory effect of n-hexane and sesquiterpene extract of A. tricolor with UV erythema test as a result, hence A. tricolor extracts can be used for the treatment of inflammatory skin diseases due to anti-inflammatory activity.

Anthemis tricolor Containing Unusual Totarol with Cytotoxic and Acetylcholinesterase‐Inhibitory Activity

“…However, the exact chemical composition of the extract was not reported in this study. [36] Antioxidant, iNOS inhibition, and cytotoxic activity (on the limited cell line human osteosarcoma (U2OS)) and cervical cancer (HeLa) of the chloroform extracts of A. tricolor were performed. [37] Studies on other Anthemis species present a great potential for this genus as a source of potential pharmaceutically active compounds, which prompted us to conduct the present study.…”

“…The n ‐hexane, chloroform, and total sesquiterpene extracts of A. tricolor were the subject of another investigation for their in vivo anti‐inflammatory activity; all extracts showed significant activity, except the chloroform extract. However, the exact chemical composition of the extract was not reported in this study [36] . Antioxidant, iNOS inhibition, and cytotoxic activity (on the limited cell line human osteosarcoma (U2OS)) and cervical cancer (HeLa) of the chloroform extracts of A. tricolor were performed [37] .…”