Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation

Patil, Kiran; Patil, Chandragouda R.

doi:10.1016/j.jtcme.2016.02.001

Cited by 40 publications

(40 citation statements)

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“…The formation of granuloma tissues were enhanced by pro-inflammatory mediators, reactive oxygen species and lysosomal enzymes activities [16]. This study revealed that BA and BAA exhibited potent antiinflammatory activity [5]. This implied that the compounds can enhance the upregulation of anti-inflammatory cytokines or downregulation of pro-inflammatory mediators such as: nitric oxide, myeloperioxidase and some interleukins [5].…”

Section: Iron Chelationmentioning

confidence: 83%

“…This study revealed that BA and BAA exhibited potent antiinflammatory activity [5]. This implied that the compounds can enhance the upregulation of anti-inflammatory cytokines or downregulation of pro-inflammatory mediators such as: nitric oxide, myeloperioxidase and some interleukins [5]. Previously, pentacyclic triterpenes like bartogenic acid have been reported to possess antiinflammatory activity.…”

Section: Iron Chelationmentioning

confidence: 86%

“…Despite the potency of current drugs like: donapezil, rivastigmi and tacrine, they are still associated with side effects such as: liver damages, gastrointestinal tract disturbance and nervous breakdown [4]. In contrast to this limitation, natural products exhibit preferable pharmacological profile accompanied by lower toxicities, affordability, and availability [5].…”

Section: Introductionmentioning

confidence: 99%

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Anti-oxidant, anti-inflammatory and antiacetylcholinesterase activity of betulinic acid and 3β- acetoxybetulinic acid from <i>Melaleuca bracteata</i> ‘Revolution Gold’

Osunsanmi¹,

Zharare²,

Mosa³

et al. 2019

Trop. J. Pharm Res

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Purpose: To evaluate the anti-oxidant, anti-inflammatory and anti-acetylcholine esterase activities of betulinic acid (BA) and 3β-acetoxybetulinic acid (BAA) from Melaleuca bracteata. 'Revolution Gold'. Methods: Betulinic acid was isolated from the ethyl acetate extract of M. braceteata while BAA was synthesized by acetylation of BA. Structural elucidation of the compounds was achieved by spectroscopic methods. Antioxidant potential was determined using superoxide dismustase (SOD) and catalase assay kits while iron chelation activity assessed with ferrozin. Anti-inflammatory activity was determined using cotton pellet-induced granuloma rat model. Cyclooxygenase (COX) activity evaluated by COX kits; acetylcholine kit was used for anti-acetylcholinesterase (ACHE) study. Results: The compounds significantly (p < 0.05) dose-dependently inhibited ACHE and inflammatory activity. They also significantly decreased the inhibition of SOD, catalase activity but increased iron chelation activities in a dose-dependent manner. However, BAA showed higher activity than BA for all the parameters. BAA also had a greater inhibitory effect on COX-2 than on COX-1. BAA (IC50, 0.88 mg/mL) showed better iron chelation than citric acid (0.96 ± 0.04) and EDTA (1.04 ± 0.03), the positive control. Conclusion: BA and BAA possess anti-ACHE, anti-inflammatory, antioxidant and anti-COX activities. Structural modification of BAA influences its biological activities. Therefore, BAA can potentially serve as a scaffold in synthesizing potent neurodegeneration drugs.

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Section: Iron Chelationmentioning

confidence: 83%

Section: Iron Chelationmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Anti-oxidant, anti-inflammatory and antiacetylcholinesterase activity of betulinic acid and 3β- acetoxybetulinic acid from <i>Melaleuca bracteata</i> ‘Revolution Gold’

Osunsanmi¹,

Zharare²,

Mosa³

et al. 2019

Trop. J. Pharm Res

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“…Moreover, the hyperalgesia (exacerbated sensitivity to thermal and mechanical stimuli) provoked by carrageenan, makes it appropriate for the study inflammatory pain [29]. Two phases of inflammation are induced by λ-carrageenan: the first -that occurs within an hour of injection -that is associated with histamine, serotonin and bradykinin liberation, and the secondfrom 1-3 or more hours -characterized by prostaglandin production [30].…”

Section: Resultsmentioning

confidence: 99%

Designed for Dentistry, Articaine in NLC Improves Anaesthesia at Inflamed Tissues

Silva¹,

Lemes²,

Geronimo³

et al. 2020

Proceedings of the 5th World Congress on Recent Advances in Nanotechnology

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Although used on a regular basis, local anaesthetics fail in places where inflammation is present, a problem for routine dental care. Intrinsic factors of the inflammatory process prevent anaesthetics from performing their function, at safe doses. The encapsulation of local anaesthetics in nanostructured lipid carriers (NLC) produces formulations with good physicochemical characteristics and improved anaesthetic effect. In that sense we developed an NLC formulation for articaine (ATC), a local anaesthetic with increasing use in dentistry. The developed formulation showed average particle sizes of 237.6 ± 3.3 nm, low polydispersity (PDI=0.169 ±0.015) and negative zeta potentials (-42.1 ± 0.5 mV), suitable for parenteral application. ATC was successfully encapsulated (%EE = 66.8 ± 2.3%) in such lipid nanocarriers. When tested in vivo, in a rodent carrageenan-induced inflammation model, NLC-ATC decreased by 35% the inflammatory hyperalgesia response, in relation to free articaine. These results had encouraged us to propose further clinical evaluation tests to test the formulation in dentistry.

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“…Carrageenan injection into the sub plantar surface of rat paw is characterized by biphasic response with the involvement of different inflammatory mediators. The early phase observed (1-2 h) is mediated by histamine and serotonin and delayed phase (3-4 h) is mediated with the release of prostaglandins 26 . Our results indicate that the administration of SC-EA extracts inhibited the edema during acute phase of inflammation probably by inhibiting the chemical mediators of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

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Anti-inflammatory activity of the SC-EA extract of the marine Streptomyces carpaticus was studied in Wistar rats using acute and chronic inflammatory models like carrageenan induced paw edema and cotton pellet induced granuloma models respectively. The acute toxicity of SC-EA extract was tested on adult Wistar rats. The maximum dose of SC-EA extract at 2000mg/kg does not show any sign of visual changes in physical behaviour, protein level and enzyme activities of AST, ALT, and ALP after 14 days of administration in rats. The SC-EA extract of 50mg/kg and100 mg/kg, p.o. demonstrated the inhibition of paw edema to 42.18% and 47.08% respectively and standard diclofenac showed 46.78% inhibition after 4 h of carrageenan treatment. In cotton pellet induced granuloma, maximum inhibition was accounted with SC-EA extract 58.3% at a dose of 100mg/kg and the suppression of inflammation was comparable to Diclofenac (30mg/kg), which reduced the weight of cotton pellet granuloma by 56.5%. The hydroxyproline which is a major component of the protein collagen was also estimated in SC-EA extract treated rats. This was measured as 17.3µg/mg with SC-EA extract at 100mg, whereas Diclofenac group showed 15.60µg/mg tissue.

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Anti-inflammatory activity of bartogenic acid containing fraction of fruits of Barringtonia racemosa Roxb. in acute and chronic animal models of inflammation

Cited by 40 publications

References 54 publications

Anti-oxidant, anti-inflammatory and antiacetylcholinesterase activity of betulinic acid and 3β- acetoxybetulinic acid from <i>Melaleuca bracteata</i> ‘Revolution Gold’

Anti-oxidant, anti-inflammatory and antiacetylcholinesterase activity of betulinic acid and 3β- acetoxybetulinic acid from <i>Melaleuca bracteata</i> ‘Revolution Gold’

Designed for Dentistry, Articaine in NLC Improves Anaesthesia at Inflamed Tissues

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