Anti-inflammatory activity of caffeine (1,3,7-trimethylxanthine) after experimental challenge with virulent Listeria monocytogenes in Swiss mice

Almeida, Ingrydt de Alcântara; Dorvigny, Betty Mancebo; Tavares, Lethicia Souza; Santana, Lucas Nunes; Lima‐Filho, José Vitor

doi:10.1016/j.intimp.2021.108090

Cited by 14 publications

(10 citation statements)

References 26 publications

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“…Other studies have found that caffeine can eliminate oxidative stress and neuroin ammation in vivo through the Nrf2/TLR4 pathway [33]. Recently, researchers injected caffeine into mice infected with Listeria monocytogenes and found that caffeine has anti-infective and anti-in ammatory activities [34]. These studies show that caffeine has a signi cant protective effect on in ammation in vivo.…”

Section: Discussionmentioning

confidence: 97%

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Guo

Liao

Zhou

et al. 2023

Preprint

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Objectives In this study, assessing whether coffee consumption and caffeine intake were associated with periodontitis infection separately was set as the objective. Materials and Methods Divided into binary and continuous categories, coffee consumption was set as the exposure variable along with caffeine intake and periodontitis infection as the outcome variables. Other covariables were regarded as potential confounders. The cross-sectional study was conducted based on the National Health and Nutrition Examination Survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome. Results Negative associations were discovered between binary coffee consumption and caffeine intake and periodontitis infection, with all confounders adjusted. In subgroup analyses stratified by sex, diabetes mellitus status, and hypertension status, interaction and threshold effects were observed, which were revealed intuitively by smooth-fitting curves. Conclusions Significant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and periodontitis infection risk. The benefits of the behavior of consuming coffee and consuming caffeine were more obvious among males and individuals who do not suffer from diabetes or hypertension.

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Section: Discussionmentioning

confidence: 97%

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Guo

Liao

Zhou

et al. 2023

Preprint

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“…The anti-inflammatory effect of caffeine varies with the treatment protocols and doses ( Feld et al, 2015 ; de Alcântara Almeida et al, 2021 ). Bile duct ligation (BDL) in rats is a common animal model of liver cirrhosis, and previous studies have demonstrated that BDL rats have significantly higher portal pressure, elevated total bilirubin (TB), AST, and ALT compared to sham-operated rats, indicating the typical presentation of liver cirrhosis ( Chang et al, 2019 ).…”

Section: Adenosine Signaling In the Livermentioning

confidence: 99%

Caffeine in liver diseases: Pharmacology and toxicology

et al. 2022

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We have previously shown that adenosine A1AR antagonists, adenosine A2aAR antagonists, and caffeine have significant inhibitory effects on the activation and proliferation of hepatic stellate cells in alcoholic liver fibrosis. Many recent studies have found that moderate coffee consumption is beneficial for various liver diseases. The main active ingredient of coffee is caffeine, which is a natural non-selective adenosine receptor antagonist. Moreover, numerous preclinical epidemiological studies and clinical trials have examined the association between frequent coffee consumption and the risk of developing different liver diseases. In this review, we summarize and analyze the prophylactic and therapeutic effects of caffeine on various liver diseases, with an emphasis on cellular assays, animal experiments, and clinical trials. To review the prevention and treatment effects of caffeine on different liver diseases, we searched all literature before 19 July 2022, using “caffeine” and “liver disease” as keywords from the PubMed and ScienceDirect databases. We found that moderate coffee consumption has beneficial effects on various liver diseases, possibly by inhibiting adenosine binding to its receptors. Caffeine is a potential drug for the prevention and treatment of various liver diseases.

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“…Caffeine has been shown to exert various health benefits, including the prevention of a diverse set of diseases including some types of cancer [ 1 ]. Bacterial infection and hyperoxia-mediated inflammation can also be alleviated by caffeine [ 13 , 14 , 15 ]. Inflammation can elicit hepcidin overexpression via the IL-6/STAT3 pathway [ 9 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Caffeine has been shown to repress Pseudomonas aeruginosa infection-mediated inflammation by inhibiting miR-301b [ 13 ]. In Listeria monocytogenes -infected mice, leukocyte infiltration and the levels of cytokines were reduced after caffeine administration [ 14 ]. Moreover, hyperoxia-mediated pulmonary inflammation in rat pups was mitigated by the intraperitoneal injection of caffeine [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway

Geng

Dou

et al. 2022

Life

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Caffeine is well-known as a psychostimulant, and it can also be beneficial in numerous diseases such as diabetes and different types of cancer. Previous studies have shown that caffeine can have a protective role in bacterial infection-induced inflammation and hyperoxia-mediated pulmonary inflammation. Hepcidin, which is regulated by the IL-6/STAT3 inflammation pathway, is a peptide hormone that maintains systemic iron homeostasis. We hypothesized that caffeine’s effects on inflammation may also influence hepcidin production and therefore systemic iron metabolism. To this end, we treated 2-month-old mice with caffeine by daily intragastric administration for 7 days, administering intraperitoneal LPS after the final caffeine treatment. Twelve hours after LPS treatment the mice were euthanized, and tissues were collected. We found that caffeine decreased hepatic hepcidin expression and attenuated LPS-induced hepatic hepcidin overexpression. IL-6 expression and STAT3 phosphorylation were also reduced upon caffeine administration. Additionally, hepatic and splenic FPN1 levels increased after caffeine treatment, leading to lower iron levels in liver and spleen tissues and higher iron levels in serum. Caffeine also prevented the increase in spleen weight and decrease in body weight after LPS treatment. Together, our findings suggest that caffeine decreases hepcidin expression via inhibiting inflammation and the activation of the IL-6/STAT3 pathway, thus presenting an attractive, potential therapeutic for the treatment of anemia of inflammation.

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Anti-inflammatory activity of caffeine (1,3,7-trimethylxanthine) after experimental challenge with virulent Listeria monocytogenes in Swiss mice

Cited by 14 publications

References 26 publications

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Caffeine in liver diseases: Pharmacology and toxicology

Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway

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