Anti-Inflammatory Activity of Cajanin, an Isoflavonoid Derivative Isolated from Canavalia lineata Pods

Hong, Su-Jin; Kwon, Ok‐Kyoung; Hwang, Daseul; Goo, Su Hyun; Kim, Doo-Young; Kim, Min Ha; Kim, Soo‐Young; Jang, Hyun‐Jae; Oh, Sei‐Ryang

doi:10.3390/ijms23169492

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…is a vine plant living in Korea, Japan, China, and Taiwan, and its aged beans contain bioactive compounds. C. lineata has also been reported as a cause of miscarriage and traditionally has been used to prevent pregnancy [34,35]. In a previous study, we found that medicarpin (MC) and homopterocarpin isolated from C. lineata showed potent hMAO-B inhibition [36].…”

Section: Introductionmentioning

confidence: 94%

Ameliorative Effect of Medicarpin on Scopolamine-Induced Cognitive Impairment in Mice

Park

Mun

et al. 2023

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The ameliorative effect of medicarpin (MC) was investigated by animal behavioral experiments such as Morris water maze (MWM), Y-maze, and passive avoidance test (PAT), using scopolamine-induced cognitively impaired mice. The scopolamine (5 mg/kg), donepezil (5 mg/kg), and MC (5 and 15 mg/kg) were administered by intraperitoneal injection at a volume of 0.3 mL. In the MWM, the escape latency times of MC-treated groups were significantly decreased compared with the scopolamine-treated negative control, and times spent in the platform zone of MC-treated groups were increased dose-dependently. In the Y-maze, the zone alternations of the MC-treated group were increased to the level of the donepezil-treated positive control. In the PAT, the crossing times of MC-treated groups were significantly higher than those of the negative control with dose-dependency. On the other hand, the monoamine oxidase (MAO)-A, MAO-B, and acetylcholinesterase (AChE) activities, relating to cognitive functions, in hippocampus treated with MC were decreased. In addition, the AChE activity in SH-SY5Y cells was significantly decreased. In Western blots, phosphorylated cyclic adenosine monophosphate (cAMP) response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), phosphorylated protein kinase B (p-Akt), and dopamine D2 receptor (D2R) levels in the hippocampus were higher than those of the negative control. In addition, p-CREB, BDNF, p-Akt, and D2R levels in SH-SY5Y cells treated with MC were significantly increased. These results showed that MC ameliorated a cognitive function along with increased BDNF and D2R expressions, and they suggested that MC could be used for the treatment of neurological disorders such as Alzheimer’s disease and Parkinson’s disease.

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Section: Introductionmentioning

confidence: 94%

Ameliorative Effect of Medicarpin on Scopolamine-Induced Cognitive Impairment in Mice

Park

Mun

et al. 2023

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“…Literature data have highlighted that cajanin is the major anti‐inflammatory compound in pigeon pea and can be a promising candidate for the treatment of inflammatory diseases. More specifically, cajanin attenuated LPS‐induced expression of nitric oxide (NO; IC 50 = 19.38 ± 0.05 µM), IL‐6 (IC 50 = 7.78 ± 0.04 µM), and TNF‐α (IC 50 = 26.82 ± 0.11 µM) in RAW 264.7 macrophages (Hong et al., 2022). This is achieved probably by preventing the phosphorylation and nuclear translocation of nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB).…”

Section: Health Benefits Of Pigeon Pea and Its Bioactive Phytochemicalsmentioning

confidence: 99%

Strategies to promote the dietary use of pigeon pea (Cajanus cajan L.) for human nutrition and health

Wu,

Zhou,

Zhou

et al. 2024

Food Frontiers

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Pigeon pea (Cajanus cajan L.) is one of the most important legume crops grown in subtropical and tropical regions with high nutritional quality. However, the consumption of pigeon pea is very limited worldwide owing to its high level of anti‐nutrients, hard texture, and unpleasant characteristic taste. The present review summarized the nutritional profile and health benefit of pigeon pea with special attention to its bioactive phytochemicals (e.g., cajanin, cajanol, and cajaninstilbene acid). Furthermore, some aspects that can help promote the application of pigeon pea in foods were highlighted from the perspectives of physical (i.e., thermal, extrusion, and ultrasound‐assisted), chemical (i.e., chemical modification and enzymatic hydrolysis), and biological treatment (i.e., sprouting and fermentation). The primary impact of physical methods was confined to the mitigation of anti‐nutrients. Chemical approaches were less explored and mainly targeted on the modification of starch and protein in pigeon pea. In contrast, the biological methods were found to decrease the level of anti‐nutritional factors, increase the production of bioactive phytochemicals, and improve the sensory properties of pigeon pea. Therefore, biological methods, especially sprouting techniques, are considered to be more promising.

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“…Both cajanin (3’,5-dihydroxy-7-methoxy-isoflavone) and prunetin (5-hydroxy-7-methoxy-isoflavone) may inhibit IκBα and p65 phosphorylation. However, cajanin but not prunetin can suppress the nuclear translocation of NF-κB ( 150 ). Interestingly, apigenin, luteolin, and fisetin have been reported to inhibit the transcriptional activity of NF-κB but have not had any effects on IκBα degradation, p65 nuclear translocation, or p65-DNA binding ( 151 ).…”

Section: Natural Flavonoids Exhibit Protective Activity Against Oa De...mentioning

confidence: 99%

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Zhou

2023

Front. Endocrinol.

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Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for treating OA. Flavonoids are a class of naturally occurring polyphenols with anti-inflammatory properties. Structurally, natural flavonoids can be divided into several sub-groups, including flavonols, flavones, flavanols/catechins, flavanones, anthocyanins, and isoflavones. Increasing evidence demonstrates that natural flavonoids exhibit protective activity against the pathological changes of OA by inhibiting the NF-κB signaling pathway. Potentially, natural flavonoids may suppress NF-κB signaling-mediated inflammatory responses, ECM degradation, and chondrocyte apoptosis. The different biological actions of natural flavonoids against the NF-κB signaling pathway in OA chondrocytes might be associated with the differentially substituted groups on the structures. In this review, the efficacy and action mechanism of natural flavonoids against the development of OA are discussed by targeting the NF-κB signaling pathway. Potentially, flavonoids could become useful inhibitors of the NF-κB signaling pathway for the therapeutic management of OA.

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Anti-Inflammatory Activity of Cajanin, an Isoflavonoid Derivative Isolated from Canavalia lineata Pods

Cited by 5 publications

References 38 publications

Ameliorative Effect of Medicarpin on Scopolamine-Induced Cognitive Impairment in Mice

Ameliorative Effect of Medicarpin on Scopolamine-Induced Cognitive Impairment in Mice

Strategies to promote the dietary use of pigeon pea (Cajanus cajan L.) for human nutrition and health

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

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