Anti-inflammatory activity of ethanolic extract of Alpinia galanga in carrageenan induced pleurisy rats

Abstract

Background: Alpinia galanga belonging to Zingiberaceae family was traditionally used to treat numerous inflammatory disorders. The rationale behind its use since ages has to be scientifically validated for developing newer therapeutic agents. Aims and Objectives: Anti-inflammatory activity of ethanolic extract of A. galanga in carrageenan induced pleurisy rats. Materials and Methods: This study was investigated on the ethanolic extract of A. galanga rhizome by scientifically validated anti-inflammatory screening technique on rats by carrageenan induced pleurisy. This pleurisy model is considered to be an excellent acute inflammatory model in which fluid extravasations, leukocyte migration and the various biochemical parameters involved in the inflammatory response can be measured easily in the exudates. Results: The results obtained indicate that the ethanolic extract had significant activity in rats in all the tested groups A. galanga 100, 200 and 400 mg with P < 0.005 compared to that of control. Conclusion: The study confirms the potential anti-inflammatory activity of ethanolic extract of A. galanga rhizome.

The use of medicinal plants for combating breast cancer: A comprehensive review

“…It has been widely used as a culinary spice and herbal medicine to cure different illnesses for many years. Many pharmacological properties including antioxidant (Malik et al 2016;Tang et al 2018), antiinflammatory (Baldo et al 2016;Subash et al 1970), antimicrobial (Saptiani et al 2016), antibacterial (Hamad et al 2016), and antiosteoarthritic activities (Chouni and Paul 2018) have been associated with this plant. This plant contains 1, 7-bis (4-hydroxyphenyl)-1, 4, 6-heparin-3-one (BH), 1,′S-1′acetoxyeugenol acetate, and (E)-8, 17-epoxylab-12-ene-15 (BDMC) (Figure 3).…”