Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice

Piornedo, Rene dos Reis; Souza, Priscila de; Stefanello, Maria Élida Alves; Strapasson, Regiane Lauriano Batista; Zampronio, Aleksander Roberto; Kassuya, Cândida Aparecida Leite

doi:10.1016/j.jep.2010.11.040

Cited by 22 publications

(14 citation statements)

References 38 publications

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“…The administration of MPEE, a proven anti-inflammatory (Piornedo et al, 2011), reduced all biomarkers in both short-term trials (comet and micronucleus assays) and the medium-term test (aberrant crypt foci). In the latter, the %DR reached 95.15, which presents the anticarcinogenic activity of M. polymorphum also in models of intestinal chemical carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Limeiras¹,

Oliveira²,

Pessatto³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has antigenotoxic potential on the tested protocols pre-and silmultaneous treatment, and the percent damage reductions (%DRs) were 81.88 and 93.12%, respectively. The micronucleus test demonstrated that MPEE has great antimutagenic activity, with %DRs higher than 77.09 in the associated groups. The aberrant crypt focus assay demonstrated anticarcinogenic potential of MPEE as the associated groups showed %DRs that ranged from 62.13 to 95.14%. The study shows that MPEE is nontoxic and has chemopreventive and anticarcinogenic activity, thus it may prove to be a promising medicinal plant in view of its demonstrated properties.

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Section: Discussionmentioning

confidence: 99%

“…), and administered by oral gavage. This dose was chosen for having effective anti-inflammatory activity; higher doses do not indicate benefits for use (Piornedo et al, 2011;David et al, 2014).…”

Section: Preparation Of the Mpeementioning

confidence: 99%

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Limeiras¹,

Oliveira²,

Pessatto³

et al. 2017

Genet. Mol. Res.

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“…Previous studies [13] indicate that 1 has anti-inflammatory action determined by the reduction of cytokine TNF-α levels. It is known that this cytokine is determinant in the tumor microenvironment, promoting proliferation and invasion of tumor cells, TNF-α also positively regulates anti-apoptotic proteins.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 1500 genera and 23,000 species constitute the plants of the family Asteraceae , the species Moquiniastrum polymorphum , native to Brazil, Paraguay, Uruguay and Argentina, is used in folk medicine for the treatment of respiratory diseases, sore throat and gastritis [11] and has anti-inflammatory, antispasmodic and antimicrobial action [12, 13], besides antioxidant, cytotoxic and antitumor activity [11, 14]. …”

Section: Introductionmentioning

confidence: 99%

Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin

Mauro

Matuo

David

et al. 2017

BMC Pharmacol Toxicol

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BackgroundIn order to obtain better clinical results in anticancer therapies, polychemotherapy or combination therapies are used. For this, the combinations are required to increase the efficacy and reduce the adverse reactions of the associated chemotherapies. The aim of this study was to evaluate the cytotoxic, apoptotic and (anti)proliferative potential of two sesquiterpene lactones isolated from Moquiniastrum polymorphum, 11,13-diidrozaluzanin C (1) and gochnatiolide C (2), and their associations with chemotherapeutic agents irinotecan, tamoxifen, cisplatin, 5-fluouracyl and doxorubicin in the tumoral lineage of MCF-7 breast adenocarcinoma.MethodsThe analyses were performed by MTT cytotoxicity assays, drug combination index (CI), apoptosis morphological assay and cell proliferation assay. Treatments were evaluated with short exposure times (4 h), followed or not by recovery in drug-free medium for 24 h. For the cell viability assay the statistical analysis was performed using software INSTAT, and the ANOVA/Tukey test was applied. Combination Indices (CI) was made using CompuSyn software and demonstrated through isoboles. The assays that evaluated cell death and proliferation used statistical analysis SAS 9.4 (Statistical Analysis System), and the procedure adopted was PROC NPAR1WAY. The Wilcoxon test at 5% level was applied for comparing statistical differences.ResultsThe results demonstrated that the compounds decrease cell viability and increase their action when associated with irinotecan, tamoxifen and doxorubicin (CI < 1 and CI = 1). In periods of 4 h-exposure, the compounds cause cell death by apoptosis and after 24 h, they increase the mean number of cells in programmed cell death, especially when treated with 2. In addition, the association with doxorubicin increases the apoptotic potential induced by tested compounds. Both isolates had effect on the reduction of the number of mitoses, especially when 2 at its highest concentration is associated with doxorubicin.ConclusionsFinally, these compounds are presented as potential agents in chemotherapy combined with doxorubicin, since they trigger the mechanism of apoptosis, which, through the mechanism of action of sesquiterpene lactones, leads to a reduction in toxicity. In addition, the tested compounds have the ability to exert a synergistic action with doxorubicin, possibly by down-regulating the drug resistance mechanisms.

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“…Struthanthus flexicaulis has been cited in some ethnobotanical studies from Northeast and Southeast regions of Brazil (Rodrigues & Carvalho 2001), as well as in pharmacological studies testing its antibacterial capacity (Vieira et al 2005;Oliveira et al 2007). Similarly, Gochnatia polymorpha and Malva parviflora have been listed in some ethnobotanical studies, and anti-inflammatory (Moreira et al 2000;Shale et al 2005;Tadeg et al 2005;Afolayan et al 2010;Piornedo et al 2011) and antispasmodic (Schlemper et al 2011) capacities have been demonstrated for these species. The results from our study demonstrate high potential of these plant species also as sources of natural antioxidants.…”

Section: Plant Species With Important Antioxidant Activitymentioning

confidence: 99%

Ethnobotany and antioxidant evaluation of commercialized medicinal plants from the Brazilian Pampa

et al. 2016

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Despite the importance of medicinal plants for the healthcare of local people, the knowledge about medicinal species used in the Pampa biome has been neglected over the years. In this study, an ethnobotanical survey was employed aiming to characterize the species richness and diversity of commercialized medicinal plant species in five cities within the Brazilian Pampa. Additionally, among the listed plants, ten species were selected for in vitro testing of their potential antioxidant activity. A total of 56 plant species belonging to 33 botanical families were listed by the 115 interviewees. No significant difference in commercialized medicinal plant species, and very similar species richness was observed among the cities, indicating that the local knowledge is consistently preserved across the studied cities. According to the biochemical analysis, Sphagneticola trilobata, Malva parviflora and Struthanthus flexicaulis emerged as very promising species for antioxidant activity. Further studies are recommended to advance our knowledge about the richness of medicinal plant species in the Brazilian Pampa, and to assess their therapeutic potential.

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Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice

Abstract: The results suggest that EEGP, and BT and DCM fractions from G. polymorpha possess anti-inflammatory activity and probably the compound 11,13-dihydrozaluzanin C was responsible, at least in part, for this action.

Cited by 22 publications

References 38 publications

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin

Ethnobotany and antioxidant evaluation of commercialized medicinal plants from the Brazilian Pampa

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