Anti-inflammatory activity of flavonoids from Chrozophora tinctoria

Abdallah, Hossam M.; Almowallad, Fahad M.; Esmat, Ahmed; Shehata, Ibrahim; Abdel‐Sattar, Essam

doi:10.1016/j.phytol.2015.05.008

Cited by 57 publications

(44 citation statements)

References 25 publications

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“…Apigenin and quercetin glycosides (Noori, ) and the acylated flavone glucosides have been reported as the phenolic compounds in C. tinctoria (Delazar et al, ). New acylated flavonoids, including (acacetin‐7‐O‐b‐D‐[a‐L‐rhamnosyl],‐E‐ p ‐coumaroyl glucopyranoside, apigenin, and rutin, have been identified in C. tinctoria accessions originated from Saudi Arabia (Abdallah et al, ). Six different flavones, such as apigenin‐7‐O‐ β ‐D‐glucopyranoside and rutin, have been identified in C. tinctoria which exhibited bone cell proliferation properties (Abdel‐Naim et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…It belongs to the subtribe Chrozophorinae, tribe Chrozophoreae, and subfamily Acalyphoideae (Gibbs, ). C. tinctoria has been traditionally used as an emetic substance and to treat cathartic warts and fever (Abdallah, Almowallad, Esmat, Shehata, & Abdel‐Sattar, ), whereas roots are given to children for cough. The C. tinctoria seeds are purgative or cathartic (Ugurlu & Secmen, ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, discovering new natural ingredients for medical applications has recently attracted considerable attention (Marzouk et al, 2016). As well-established in the literature, the compositions of C. tinctoria plants vary greatly depending on their geographical origins (Abdallah et al, 2015;Marzouk et al, 2016;Oke-Altuntas, Ipekcioglu, Sahin Yaglioglu, Behcet, & Demirtas, 2017).…”

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Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

2019

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The present study was conducted to determine the total phenolics, flavonoids, flavonols, anthocyanin, and carotenoids as well as the antioxidant activity of 10 different Crozophora tinctoria accessions originated from Iran. The highest contents of total phenolics, flavonoids, flavonols, anthocyanin, and carotenoids were detected in C.t (2), C.t (10), C.t (10), C.t (9), and C.t (3) accessions, respectively. The highest antioxidant activities of the samples, evaluated using 1,1‐diphenyl‐2‐picrylhydrazyl and phosphomolibdate assays, were detected in C.t (8) and C.t (3), respectively. The highest phenyl aminolyase activity was observed in C.t (4). Ten phenolic compounds, including quercetin, catechin, ellagic acid, rosmarinic acid, hesperetin, eugenol, hesperidin, carvacrol, thymol, and kaempferol were identified and quantified using high‐performance liquid chromatography (HPLC) technique. The best anticancer activity against HeLa cell lines was observed at C.t (8) accession, originated from Qazvin Region. This study confirmed that the C. tinctoria accessions with rich phenolics compounds may be recommended as a novel source of natural antioxidants for future aims in medicinal fields. Practical applications According to this findings there was high variation among phenolics compounds of C. tinctoria which is revealed by HPLC analysis. This study identified phenolic compounds with antioxidant and anticancer activity in Iranian accessions of C. tinctoria. With an increase in the rate of cancer disease, superior accessions of C. tinctoria may be recommended as a novel source of natural antioxidants for ethno pharmacological aims as cancer therapy, and also in nutraceutical fields.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

2019

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“…However, the practice of creating the blue color fell out of use and it was lost in the 19th century. Its medicinal properties were first described by Dioscorides (De Materia Medica, 1st century) and were also mentioned in medieval pharmacopoeia texts, and studies focusing on its anti-inflammatory properties have been published recently (14)(15)(16). The dyeing properties of this species and their applications are a fascinating subject that will be revisited, as it is relevant to this research.…”

Section: Chrozophora Tinctoria In Medieval and 19th Century Written Smentioning

confidence: 96%

A 1000-year-old mystery solved: Unlocking the molecular structure for the medieval blue from Chrozophora tinctoria , also known as folium

et al. 2020

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The molecular structure of the medieval watercolor known as folium has finally been solved in the 21st century. The interdisciplinary approach taken was the key to producing extracts that had been prepared following medieval instructions, and shows the blue/purple chromophore as the major dye in Chrozophora tinctoria fruits (shell). A multi-analytical characterization of its structure was made using HPLC-DAD-MS, GC-MS, NMR (1H, 13C, COSY, HSQC, HMBC, INADEQUATE), and computational studies. The results demonstrate that the blue compound corresponds to 6′-hydroxy-4,4′-dimethoxy-1,1′-dimethyl-5′-{[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-[3,3′-bipyridine]-2,2′,5,6(1H,1′H)-tetraone, a hermidin derivative, which we named chrozophoridin. Experimental data and computational modeling studies show that this mono-glycosylated dimer is represented by two stable isomers (atropisomers). This is an indispensable piece of knowledge for the characterization of this medieval dye in works of art such as medieval manuscript illuminations and for testing its stability and contributes to the preservation of our cultural heritage.

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“…Many phyto-chemical constituents have been found in different Chrozophora species, including alkaloids, coumarins (Abdel-Sattar, 1985), diterpenoids (Tabussum et al, 2013), phenylpropanoid glycosides (Mohamed 2001), phenolic acids, tannins, anthraquinones, saponins and xanthones (Usman et al, 2007) and flavonoids (Hawas 2007). In addition, it has been reported that C. tinctoria has antioxidant (Oke-Altuntas et al, 2017), antimicrobial (Usman et al, 2007) and anticancer (Jamil et al, 2012) characteristics as well as anti-inflammatory (Abdallah et al, 2015), anti-proliferative (Oke-Altuntas et al, 2017) and wound-healing (Maurya and Semwal, 2016) properties. Due to its unique geographical position and climate situation, Iran possesses a rich flora.…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical properties and fatty acid composition of <em>Chrozophora tinctoria</em> seeds as a new oil source

et al. 2019

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Chrozophora tinctoria L., usually known as dyer’s Croton, Turnsole or Giradol, has been used in various medicinal and food products for many years. However, no comprehensive research has been undertaken to assess its potential as a new seed oil crop. Therefore, the current study examined the fatty acid composition, physico-chemical properties and antioxidant activity of C. tinctoria seeds, grown in the southwest of Iran. The seed oil content was found to be 26.40%. The extracted oil was analyzed for fatty acid composition using gas chromatography (GC). The results showed that unsaturated fatty acids accounted for almost 91% of the total fatty acids. Linoleic acid was the dominant fatty acid (76.68%), followed by oleic acid (13.99%) and palmitic acid (5.32%). δ-tocopherol was the major tocopherol in the oil, representing 70 mg/100 g oil. The total phenolic content (151.70 mg GAE per 100 g oil) and total flavonoid content (1.17 mg QE oil) were also determined in the extracted oil. The antioxidant activity was measured by a DPPH assay and expressed as 45% of the seed oil. Due to its high oil yield and high unsaturated fatty acid content, C. tinctoria could be regarded as a new source of edible oil.

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Anti-inflammatory activity of flavonoids from Chrozophora tinctoria

Cited by 57 publications

References 25 publications

Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

A 1000-year-old mystery solved: Unlocking the molecular structure for the medieval blue from Chrozophora tinctoria , also known as folium

Physico-chemical properties and fatty acid composition of <em>Chrozophora tinctoria</em> seeds as a new oil source

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