Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium

Manosroi, Aranya; Jantrawut, Pensak; Manosroi, Jiradej

doi:10.1016/j.ijpharm.2008.04.033

Cited by 155 publications

(87 citation statements)

References 20 publications

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“…Gel containing a specified amount of Carbopol Õ 934 was dispersed in the dispersion of ultradeformable vesicles with gentle stirring to obtain the total drug equivalent to Tenoxicam 0.1% w/w [10]. Free drug gel was prepared by a similar method using 1.5% carbopol (Table 1).…”

Section: Preparation Of Nano-vesicular and Free Drug Gelsmentioning

confidence: 99%

Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system

Negi

Chauhan

Garg

2013

Journal of Experimental Nanoscience

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Tenoxicam is one of the potent non-steroidal anti-inflammatory drugs (NSAIDs), which is used clinically in the treatment of rheumatoid arthritis. Like other NSAIDs, Tenoxicam also suffers from the drawback of being associated with gastrointestinal side effects. Further, transdermal penetration of this drug is very poor, which circumvents the use of transdermal route. The main objective of this study is to exploit the concept of ultradeformable vesicles to increase the transport of Tenoxicam through transdermal route, and also to present it as a possible replacement for the oral NSAID therapy for rheumatoid arthritis. Three concentrations (5%, 15% and 25%) of three different surfactants (Tween-80, Span-80 and sodium desoxycholate) were used along with soya lecithin to prepare the ultradeformable vesicles. Among nine different types of vesicles, T3 vesicles (with 25% Tween-80) were found to have shown the smallest size (82.80 AE 0.74 nm), highest release in 24 h (98.01 AE 0.33%) and highest deformability (31.27 AE 0.28) and hence chosen for formulating into the gel. Among three different Carbopol Õ 934 concentrations (1%, 1.5% and 2%), G-2 with 1.5% carbopol was chosen as the final formulation. The formulation has shown almost twice the transdermal flux as compared to the gel with free Tenoxicam. The in vivo performance was also found to be significantly better than the oral Tenoxicam and marketed aceclofenac gel (Hifenac Õ ). This study concluded that the gel containing Tenoxicam encapsulated in ultradeformable vesicles has a better prospective for the transdermal use to treat rheumatoid arthritis.

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Section: Preparation Of Nano-vesicular and Free Drug Gelsmentioning

confidence: 99%

Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system

Negi

Chauhan

Garg

2013

Journal of Experimental Nanoscience

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“…Besides, it has been determined that the noisome formulation has a faster anti-inflammatory activity than the commercial gel formulation (Shahiwala & Misra, 2002). Manosroi et al (2008) obtained a higher flux of the drug in SC and deeper dermal tissues (live epidermis and dermis) with elastic noisome formulations loaded with diclophenac diethylammonium. Niosome-like vesicles consisting of hydrated mixtures of cholesterol and non-ionic surfactants are defined as "proniosomes" (Alsarra et al, 2005;Ammar et al, 2011).…”

Section: Niosomesmentioning

confidence: 90%

Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs

Okyar¹,

Özsoy²,

Güngör³

2012

Rheumatoid Arthritis - Treatment

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“…They can entrap both water and oil soluble substances similar to liposomes, but with lower cost and more chemical stability than liposomes. The enhancement of physical and chemical stability of many antioxidants and drug such as diclofenac diethylammonium (DCFD) (Manosroi et al, 2008), protein such as gallidermin (Manosroi et al, 2010c) as well as DNA such as luciferase plasmid (Manosroi et al, 2009(Manosroi et al, , 2010d when entrapped in niosomes has been demonstrated.…”

Section: Research Articlementioning

confidence: 99%

In vitroandin vivoskin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid fromTerminalia chebulagalls

Manosroi¹,

Jantrawut²,

Akihisa³

et al. 2011

Pharmaceutical Biology

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Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium

Cited by 155 publications

References 20 publications

Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system

Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system

Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs

In vitroandin vivoskin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid fromTerminalia chebulagalls

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