Anti-inflammatory activity of hydroalcoholic extract of mimosa pudica whole plant in rats

Abstract

Background: Mimosa pudica is a traditionally used folk medicine to treat various disorders like infections, anxiety, depression, bleeding disorders, convulsions, rheumatoid arthritis, muscular pain, asthma, snake bite etc. We evaluated the anti-inflammatory activity of hydroalcoholic extract of Mimosa pudica whole plant (HAEMPWP) in rats.Methods: HAEMPWP was prepared using Soxhlets apparatus. Acute toxicity tests were done with HAEMPWP given orally to albino rats in increasing doses up to 3200 mg/ kg body weight. The anti-inflammatory action was evaluated by Carrageenan induced paw edema method. Thirty albino rats were grouped into five groups and each contained six rats. Group I (control group) received distilled water orally. Group II (standard) received Aspirin orally dissolved in distilled water. Groups III, IV and V received HAEMPWP in doses of 200 mg/kg, 400 mg/kg and 800mg/kg orally dissolved in distilled water. Data analysis was done by one way ANOVA and unpaired t test using SPSS 16 for windows.Results: HAEMPWP showed a significant anti-inflammatory activity as compared to control. There was no statistically significant dose dependent increase in the anti-inflammatory activity.Conclusions: HAEMPWP possesses significant anti-inflammatory activity and could be an effective treatment option for various inflammatory conditions.

A Review on the Pharmacological and Traditional Properties of Mimosa Pudica

“…Two hundred (200) mg/kg, 400 mg/kg and 800 mg/kg extracts of M. puidca was administered to three different groups, 800 mg/kg concentration has the highest percentage inhibition. The result from this recent study also shows that M. pudica has anti-inflammatory properties [39].…”