Anti-inflammatory activity of<i>Gentiana striata</i>Maxim.

Cao, F Q; Shao, Hao; Li, Qiang; Li, Jinrong; Li, Wenqun; Li, Chong

doi:10.1080/14786419.2010.551643

Cited by 16 publications

(3 citation statements)

References 25 publications

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“…There was a marked decrease in the PGE 2 and NO levels. Six compounds including two iridoids, loganin ( 8 ) and sweroside ( 9 ), was isolated from this extract [ 94 ].…”

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

177

110

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Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, paracetamol, indomethacin and ibuprofen as well as corticosteroids such as prednisone. These however, may be associated with a host of side effects due to non-selectivity for cyclooxygenase (COX) enzymes involved in inflammation and those with selectivity may be highly priced. Thus, there is a continuing search for safe and effective anti-inflammatory molecules from natural sources. Research has confirmed that iridoids exhibit promising anti-inflammatory activity which may be beneficial in the treatment of inflammation. Iridoids are secondary metabolites present in various plants, especially in species belonging to the Apocynaceae, Lamiaceae, Loganiaceae, Rubiaceae, Scrophulariaceae and Verbenaceae families. Many of these ethnobotanicals have an illustrious history of traditional use alluding to their use to treat inflammation. Although iridoids exhibit a wide range of pharmacological activities such as cardiovascular, hepatoprotection, hypoglycaemic, antimutagenic, antispasmodic, anti-tumour, antiviral, immunomodulation and purgative effects this review will acutely focus on their anti-inflammatory properties. The paper aims to present a summary for the most prominent iridoid-containing plants for which anti-inflammatory activity has been demonstrated in vitro and / or in vivo.

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“…There was a marked decrease in the PGE 2 and NO levels. Six compounds including two iridoids, loganin ( 8 ) and sweroside ( 9 ), was isolated from this extract [ 94 ].…”

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

177

110

View full text Add to dashboard Cite

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“…Thus, there may be great potential for the prevention and treatment of inflammation to suppress the signaling molecules of iNOS expression [9]. Previous reports have shown that the Gentiana species possesses anti-inflammatory activity [10][11][12][13][14]. Animal experiments showed that gentiopicroside possesses anti-inflammatory effects on acute and chronic inflammatory reactions [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Constituents with Activity of Inhibiting Nitric Oxide Production in Raw 264.7 Macrophages from Gentiana triflora

Wang

Jiang

et al. 2013

Planta Med

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Gentiana triflora is widely used to treat inflammation, jaundice, hepatitis, and rheumatism. In this study, three new compounds, including a benzo seven-membered ring compound, gentioxepine (1), two secoiridoid glucosides, (1S,5R,9R)-deglucosyltrifloroside (2) and (1S,5R,9R)-scabraside (3), together with seven known ones, (+)-syringaresinol (4), deglucogelidoside (5), 3,4-dihydro-1H,6H,8H-naphtho[1,2-c:4,5-c',d']dipyrano-1,8-dione (6), deglucoscabraside (7), 2-hydroxy-3-O-β-D-glucosyloxy benzoic acid methyl ester (8), gentiolactone (9), and trifloroside (10), were isolated from the ethanol extract of Gentiana triflora. Their structures were mainly confirmed on the basis of NMR, MS, IR, CD, and UV spectral evidences. Inhibiting activities of nitric oxide production of eight of the compounds isolated, as well as gentiopicroside, were evaluated in the macrophage cell line RAW 264.7. The results show that the three new compounds and compound 7 could significantly suppress lipopolysaccharide-induced production of NO, with IC50s of 2.2 µM, 37.5 µM, 17.6 µM and 6.9 µM, respectively. Among them, compounds 1, 3, and 7 showed stronger inhibitory activity than that of the clinically used drug indometacin. Other tested compounds exerted moderate inhibiting activities.

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“…[ 26 ] Tectochrysin (TEC), one of the major flavonoids of propolis, [ 27,28 ] is also present in various other natural sources, such as the plant Alpinia oxyphylla , [ 29 ] Kaempferia parviflora , [ 30 ] Muntingia calabura , [ 31 ] and Carya genus. [ 32 ] Previous pharmacological studies have shown that TEC possesses antioxidant, [ 33 ] anticancer, [ 26,34 ] antidiarrheal, [ 35 ] anti‐ Leishmania amazonensis amastigotes, [ 36 ] trypanocidal, [ 37 ] and aryl hydrocarbon receptor ligand [ 38 ] activities. Furthermore, it was also found that TEC has the ability to promote adipocyte differentiation and stimulate adipogenesis.…”

Section: Introductionmentioning

confidence: 99%

A Propolis‐Derived Small Molecule Tectochrysin Ameliorates Type 2 Diabetes in Mice by Activating Insulin Receptor β

Zhang,

Wu,

Shi

et al. 2023

Molecular Nutrition Food Res

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ScopePropolis has been found to decrease glucose levels and increase insulin sensitivity in type 2 diabetes. However, the active ingredient responsible for these effects and its regulating mechanism are not fully understood.Methods and resultsTo address this, molecular docking screening is used to screen the effective hypoglycemic ingredient in propolis and found that tectochrysin (TEC) has a high affinity to the insulin receptor (IR), highlighting its potential for glycemic control. In vivo tests show that TEC decreases glucose levels and enhances insulin sensitivity in db/db mice. By hyperinsulinemic euglycemic clamp test, this study further finds that TEC promotes glucose uptake in adipose tissue and skeletal muscle, as well as inhibits hepatic gluconeogenesis. Moreover, it finds that TEC promotes glucose uptake and adipocytes differentiation in 3T3‐L1 cells like insulin, suggesting that TEC exerts an insulin mimetic effect. Mechanistically, pharmacology inhibition of IRβ abolishes the effects of TEC on glucose uptake and the phosphorylation of IR. The study further demonstrates that TEC binds to and activates IRβ by targeting its E1077 and M1079.ConclusionTherefore, this study sheds light on the mechanism underlying propolis’ potential for ameliorating type 2 diabetes, offering a natural food‐derived compound as a promising therapeutic option.

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Anti-inflammatory activity ofGentiana striataMaxim.

Cited by 16 publications

References 25 publications

Anti-Inflammatory Iridoids of Botanical Origin

Anti-Inflammatory Iridoids of Botanical Origin

Isolation and Identification of Constituents with Activity of Inhibiting Nitric Oxide Production in Raw 264.7 Macrophages from Gentiana triflora

A Propolis‐Derived Small Molecule Tectochrysin Ameliorates Type 2 Diabetes in Mice by Activating Insulin Receptor β

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