Anti-inflammatory activity of <i>Heliotropium</i><i>strigosum</i> in animal models

Khan, Haroon; Khan, Murad Ali; Gul, Farzana; Hussain, Sajjid; Ashraf, Nadeem

doi:10.1177/0748233713491813

Cited by 15 publications

(7 citation statements)

References 12 publications

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“…This test has been commonly used as an experimental animal model for acute inflammation mainly mediated by histamine, serotonin, bradykinin and increased synthesis of prostaglandins in the damaged tissue (initial phase) which is subsequently sustained by the release of prostaglandins and nitric oxide and by the involvement of polymorphonuclear cells (second phase) (Di Rosa and Willoughby, 1971;Gupta et al, 2008). The theory that best explains anti-inflammatory and antinociceptive activities of NSAIDs in these experimental models is in part based on the discovery that these drugs inhibit prostaglandin biosynthesis (Khan et al, 2013a(Khan et al, , 2013bMuhammad et al, 2013a).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory potential of Rhododendron arboreum bark

et al. 2014

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Rhododendron arboreum Smith. (Ericaceae), an evergreen small tree, is one of the 1000 species that belongs to genus Rhododendron distributed worldwide. In folk medicine, as various parts of this plant exhibit medicinal properties, it is used in the treatment of different ailments.The present study was designed to evaluate the potential anti-inflammatory and antinociceptive effects of methanolic extract of R. arboreum bark, followed by activity-guided fractionation of n-hexane, n-butanol, chloroform, ethyl acetate and aqueous fractions.The ethyl acetate fraction (200 mg/kg i.p.) showed the maximum analgesic effect (82%) in acetic acid-induced writhing, followed, to a less extent, by crude extract and chloroform fraction both at a dose of 200 mg/kg i.p. (65.09% and 67.89%, respectively). In carrageenan-induced mouse paw oedema, the crude extract and its related fractions displayed in a dose-dependent manner (50-200 mg/kg i.p.) an anti-inflammatory activity for all time-courses (1-5 hrs). For the active extract/fractions (200 mg/kg i.p.), the maximum effect was observed 5 h after carrageenan injection. These evidences were also supported by in vitro lipoxygenase inhibitory properties. In conclusion, R. arboreum crude methanolic extract and its fractions exhibited anti-inflammatory and antinociceptive effects. For these reasons, this plant could be a promising source of new compounds for the management of pain and inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory potential of Rhododendron arboreum bark

et al. 2014

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“…Several compounds were isolated and identified from Heliotropium species such as pyrrolizidine alkaloids [23,24], flavonoids [25,26], triterpenes [27], and benzofurans [28]. Numerous biological activities of extracts and isolated compounds from Heliotropium plants were documented like antimicrobial [27], wound healing [24], antioxidant [23,25,28], antineoplastic, cytotoxic activities [26], and anti-inflammatory activity [29]. However, the bioactive compounds of H. curassavicum is not well studied, and to our knowledge, no study explores the chemical composition or the bioactivities of its EO.…”

Section: Introductionmentioning

confidence: 99%

Habitat Affects the Chemical Profile, Allelopathy, and Antioxidant Properties of Essential Oils and Phenolic Enriched Extracts of the Invasive Plant Heliotropium Curassavicum

Abd‐ElGawad

Elshamy

Al‐Rowaily

et al. 2019

Plants

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The variation in habitat has a direct effect on the plants and as a consequence, changes their content of the bioactive constituents and biological activities. The present study aimed to explore the variation in the essential oils (EOs) and phenolics of Heliotropium curassavicum collected from the coastal and inland habitats. Additionally, we determined their antioxidant and allelopathic activity against the weed, Chenopodium murale. Fifty-six compounds were identified as overall from EOs, from which 25 components were identified from the coastal sample, and 52 from the inland one. Sesquiterpenes were the main class in both samples (81.67% and 79.28%), while mono (3.99% and 7.21%) and diterpenes (2.9% and 1.77%) represented minors, respectively. Hexahydrofarnesyl acetone, (-)-caryophyllene oxide, farnesyl acetone, humulene oxide, farnesyl acetone C, and nerolidol epoxy acetate were identified as major compounds. The HPLC analysis of MeOH extracts of the two samples showed that chlorogenic acid, rutin, and propyl gallate are major compounds in the coastal sample, while vanilin, quercetin, and 4′,7-dihydroxyisoflavone are majors in the inland one. The EOs showed considerable phytotoxicity against C. murale with IC50 value of 2.66, 0.59, and 0.70 mg mL−1 for germination, root, and shoot growth, respectively from the inland sample. While the coastal sample attained the IC50 values of 1.58, 0.45, and 0.66 mg mL−1. MeOH extracts revealed stronger antioxidant activity compared to the EOs. Based on IC50 values, the ascorbic acid revealed 3-fold of the antioxidant compared to the EO of the coastal sample and 4-fold regarding the inland sample. However, the ascorbic acid showed 3-fold of the antioxidant activity of the MeOH extracts of coastal and inland samples. Although H. curassavicum is considered as a noxious, invasive plant, the present study revealed that EO and MeOH extracts of the H. curassavicum could be considered as promising, eco-friendly, natural resources for antioxidants as well as weed control, particularly against the weed, C. murale.

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“…The arachidonic acid is then metabolized by 2 distinct enzymatic pathways: cyclooxygenase into prostaglandins and lipoxygenase into leukotrienes. [11][12][13][14] Prostaglandins are members of the eicosanoid family produced by almost all cells of the human body-the principal mediator of inflammation in most of the inflammatory diseases. 15,16 The inflammatory mediators approach from plasma proteins or cells including mast cells, platelets, neutrophils, and monocytes/macrophages, which are activated by bacterial products or host proteins.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Attenuation of Thermal-Induced Protein Denaturation by Aerial Parts of Artemisia scoparia

Khan

Tariq

et al. 2014

J Evid Based Complementary Altern Med

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The goal of this study was to explore the aerial parts of Artemisia scoparia (crude extract, total flavonoid contents, and aqueous fraction) for protein denaturation potential. The crude extract provoked marked attenuation of thermal-induced denatured protein in a concentration-dependent manner with maximum inhibition of 54.05 mg/mL at 500 mg/mL and IC 50 of 449.66 mg/mL. When total flavonoid contents were studied, it illustrated most dominant activity concentration dependently with maximum amelioration of 62.16 mg/mL at 500 mg/mL and IC 50 of 378.35 mg/mL. The aqueous fraction also exhibited significant activity with maximum of 56.75% inhibition at 500 mg/mL and IC 50 of 445.10 mg/mL. It can be concluded on the basis of the results that the crude extract, flavonoid contents, and aqueous fraction of the plant possessed significant inhibition on thermal-induced denatured protein.

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Anti-inflammatory activity of Heliotropiumstrigosum in animal models

Cited by 15 publications

References 12 publications

Antinociceptive and anti-inflammatory potential of Rhododendron arboreum bark

Antinociceptive and anti-inflammatory potential of Rhododendron arboreum bark

Habitat Affects the Chemical Profile, Allelopathy, and Antioxidant Properties of Essential Oils and Phenolic Enriched Extracts of the Invasive Plant Heliotropium Curassavicum

In Vitro Attenuation of Thermal-Induced Protein Denaturation by Aerial Parts of Artemisia scoparia

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