Anti-inflammatory activity of Jatropha curcas Linn. latex in cream formulation on CD68 expression in mice skin wound

Salim, Muhammad Agus; Masyitha, Dian; Harris, Abdul; Balqis, Ummu; Iskandar, Cut Dahlia; Hambal, Muhammad; Darmawi, Darmawi

doi:10.14202/vetworld.2018.99-103

Cited by 34 publications

(29 citation statements)

References 45 publications

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“…Tannins are included as antinutrients in legumes which inhibit the digestion of protein but are destroyed by cooking to increase the functions of amylase and protease and better protein digestion 29 . Dietary tannins, flavonoids and saponins found in P. vulgaris like other plant sources, are known for their medicinal importance in the preparation of herbal formulation as active constituent to take part in cancer prevention, function as antioxidants and possess antiinflammatory ability 30, 31 . Cooking reduced the content of alkaloids in cooked extract of P. vulgaris.…”

Section: Discussionmentioning

confidence: 99%

Heating Effect on Phytochemical and Proximate Contents of Cooked Aqueous Extract of Phaseolus Vulgaris (Kidney Beans)

Idoko

et al. 2020

Univ J Pharm Res

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Plant chemicals and nutrients abound in different parts of plants and in different compositions. P. vulgaris (kidney beans) is a nourishing leguminous food commonly eaten by both human beings and animals in the world due to its health benefits and risk reduction of diseases. It is however, indispensible for plants’ food stuff to retain their phytonutrients for maximum benefits. This study therefore investigated the effect of heat on the phytochemicals and proximate contents in cooked P. vulgaris (kidney beans). Qualitative and quantitative phytochemical analysis and proximate (nutrient contents) analysis were determined on fresh kidney bean (FKB) and cooked kidney bean (CKB). Results of phytochemical quantification revealed a significant (p˂0.05) increase of alkaloids and saponins in FKB than those in CKB, significant (p˂0.05) increase of flavonoids, glycosides and tannins in CKB than those in FKB. While proximate analysis of cooked sample (CKB) showed significant (p˂0.05) increase in protein content, crude ash content and carbohydrate content FKB. While moisture content, crude fibre and crude fat of FKB were significantly (p˂0.05) higher than those in CKB of Phaseolus vulgaris. Obviously, the increased concentrations of phytochemicals in fresh Phaseolus vulgaris may be due to the absence of heat action and the heating effect on cooked P. vulgaris could unleash the high rich nutrients value and could supply its antioxidants roles, thereby improving healthy life when eaten cooked. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Name: Prof. Dr. Hüsniye Kayalar Affiliation: Ege University, Turkey E-mail: husniyekayalar@gmail.com Name: Dr. Mohamed Said Fathy Al-Refaey Affiliation: University of Sadat City, Menofia, Egypt E-mail: Mohamed.said@fop.usc.edu.eg Name: Dr. Gehan Fawzy Abdel Raoof Kandeel Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt E-mail: gehankandeel9@yahoo.com Comments of reviewer(s): Similar Articles: PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL EVALUATIONS OF METHANOLIC EXTRACTS OF COCOS NUCIFERA (L.) LEAVES PHYTOCHEMICAL SCREENING AND THIN LAYER CHROMATOGRAPHIC OF PRUNUS DULCIS (ALMOND) MEDICINAL PLANT LEAVES USED IN FOLK MEDICINE FOR TREATMENT OF WOUNDS AND BURNS IN HUFASH DISTRICT AL MAHWEET GOVERNORATE–YEMEN PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT AND ANTI-DIABETIC POTENTIALS OF PERSEA AMERICANA MILL. (LAURACEAE) FRUIT EXTRACT CYTOTOXIC EFFECT AND PHYTOCHEMICAL STUDY OF PETROLEUM ETHER EXTRACT OF TILIA CORDATA MILL

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Section: Discussionmentioning

confidence: 99%

Heating Effect on Phytochemical and Proximate Contents of Cooked Aqueous Extract of Phaseolus Vulgaris (Kidney Beans)

Idoko

et al. 2020

Univ J Pharm Res

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“…A cream base was added little by little with the 10% and 15% latex of J. curcas in a porcelain dish containing 100 g of cream and stirred until homogeneous at room temperature. The dosages of 10% and 15% latex of J. curcas have been proven to be effective to use for topical for topical wound healing [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…The mice skin wound was done by mean of surgical procedures as explained by Salim et al . [ 24 ]. Mice were locally anesthetized by topical cream with containing lidocaine 25 mg and prilocaine 25 mg. Longitudinal wounds of about 2.0 cm were made on the paravertebral region till to subcutaneous under the aseptic condition and were observed throughout the experimental study.…”

Section: Methodsmentioning

confidence: 99%

Angiogenesis activity of Jatropha curcas L. latex in cream formulation on wound healing in mice

et al. 2018

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Aim:The aim of this research was to determine the angiogenesis activity of Jatropha curcas latex in cream formulation on CD34 immune expression during wound healing phase in mice skin.Materials and Methods:Amount of 36 2-month-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. All mice were divided into four groups, namely the base cream as control group (A), sulfadiazine 0.1% cream (B), Jatropha curcas latex cream 10% (C), and J. curcas latex cream 15% (D). All groups were treated entire surface of wound. All experiments were performed twice a day for 10 days. Experiments were terminated on days 3, 7, and 10, respectively. The wound healing was assayed in stained histological section in immunohistochemical of the wounds. The CD34 expression was investigated under a microscope.Results:The results showed that the cream from 10% and 15% latex J. curcas revealed moderate immune reaction to CD34 on days 3 and 7 in wound healing of mice skin.Conclusion:We concluded that the cream from 10% and 15% latex J. curcas has potential as angiogenesis activity in wound healing of mice skin.

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“…The wounded skin was sampled after the mice were euthanized for conducting histopathological slides. Procedure making histopathological preparations refers to standard methods [12]. The slides were evaluated by staining with Hematoxylin-eosin (HE) and Masson's trichrome (MT).…”

Section: Histopathological Slides Preparationmentioning

confidence: 99%

“…Previously study indicated latex of J. curcas have proven to accelerate the inflammatory phase [12], epithelial phase [13,14], and angiogenesis activity [15]. This causes that the latex of J. curcas effective to be used for topical therapy on wound healing in mice skin.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Jatropha curcas Latex Cream in The Epithelialization Phase of Wound Healing in Mice Skin

et al. 2020

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The objective of the present research was to find out the efficacy of Jatropha latex cream in the epithelialization phase of wound healing in mice skin. A total of 9 male mice aged 2-3 months old and the bodyweight of 25-40 g were divided into three treatment groups. Group A was given basic cream, group B was given Jatropha latex cream (10%), and group C was given sulfadiazine. The 2 cm incision wound was made in the paravertebral area. Wound therapy was carried out twice a day for 7 days. All quantitative data were measured using ANOVA then followed by the Duncan test. The number of angiogenesis on A, B, and C was 4.67±1.20; 12.78±2.52; and 11.33±2.33, while a number of fibroblasts were 179.56±12.69; 90.56±8.23; and 99.11±7.04, respectively. The average deposition of collagen was 1.46±0.12; 1.89±0.10; and 1.74±0.06, respectively. The statistical test showed that the number of angiogenesis, fibroblast, and deposition of collagen on group B was significantly different (P<0.05) compared to group A and showed no significant difference compared to group C (P>0.05). In conclusion, Jatropha latex cream (10%) able to accelerate the epithelialization phase of wound healing in mice skin.

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Anti-inflammatory activity of Jatropha curcas Linn. latex in cream formulation on CD68 expression in mice skin wound

Cited by 34 publications

References 45 publications

Heating Effect on Phytochemical and Proximate Contents of Cooked Aqueous Extract of Phaseolus Vulgaris (Kidney Beans)

Heating Effect on Phytochemical and Proximate Contents of Cooked Aqueous Extract of Phaseolus Vulgaris (Kidney Beans)

Angiogenesis activity of Jatropha curcas L. latex in cream formulation on wound healing in mice

Efficacy of Jatropha curcas Latex Cream in The Epithelialization Phase of Wound Healing in Mice Skin

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