Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid

Sosa, Silvio; Morelli, Carlo F.; Tubaro, Aurelia; Cairoli, Paola; Speranza, Giovanna; Manitto, Paolo

doi:10.1016/j.phymed.2005.11.002

Cited by 51 publications

(33 citation statements)

References 21 publications

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“…Terpenoids (lupenone and sitosterol) extracted from different raw materials have been shown to present anti-inflammatory activity [67][68][69][70]. However, the activity of fatty acids as anti-inflammatory agents and wound healing promoters is not so clear [71].…”

Section: Cytocompatibility and Anti-inflammatory Activitymentioning

confidence: 99%

Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology

Dias

Rey‐Rico

Oliveira

et al. 2013

The Journal of Supercritical Fluids

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a b s t r a c t N-Carboxybutyl chitosan (CBC), collagen/cellulose (Promogran ® ) and hyaluronic acid-based (Hyalofill ® ) polymeric matrices/dressings were loaded with an extract obtained from jucá (Libidibia ferrea) and in order to develop wound dressings endowed with anti-inflammatory activity. Jucá fruits were subjected to supercritical fluid extraction (SFE) using CO 2 at 25 MPa and 50• C and the resulting extract was later incorporated into the above referred wound dressings by a supercritical fluid impregnation/deposition method (SSI). GC analysis revealed that the obtained SFE extract is particularly rich in unsaturated (52%) and saturated (26%) fatty acids as well as in terpenoids (13%) such as lupenone and gamma-sitosterol. Extract loading yields depended on the affinity of the hydrophobic extract for the specifically employed wound dressing material and was almost 2-fold greater for CBC than for the other two commercial wound dressings. The prepared extract-loaded dressings were cytocompatible with RAW 264.7 macrophages (viability > 85% at 24 h) and down-regulated the expression of TNF-␣ and IL-1␣ proinflammatory cytokines as well as the production of nitric oxide, which confirms the anti-inflammatory capacity of the employed jucá extract. Nevertheless, such effect was somehow counteracted by a proinflammatory activity that was exhibited by CBC. Prepared dressings presented a wide range of water vapor ((2.9-14.7) × 10 14 kg/(s m Pa)) and oxygen permeability (150 up to 830 barrer) which make them potentially suitable for the management of various wound types at different healing stages.

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Section: Cytocompatibility and Anti-inflammatory Activitymentioning

confidence: 99%

Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology

Dias

Rey‐Rico

Oliveira

et al. 2013

The Journal of Supercritical Fluids

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“…In the antiinflammatory test, the oedema inhibition 3h after carrageenan injection was respectively 64% and 66 % for leaves and roots of M. senegalensis ). The chloroform extract of roots along with maytenoic acid exhibited highest antiinflammatory by reducing the oedematous response, with potency similar to indomethacin (Sosa et al, 2007). Leaf extracts exhibited also significant anti-inflammatory activity at the dose of 120 mg/kg, per os, reducing oedema by 51%.…”

Section: Medicinal Plants Used For Treatment Of Dysmenorrhea In Malimentioning

confidence: 88%

Medicinal Plants Traditionally Used In Mali for Dysmenorrhea

Sanogo¹

2011

Afr. J. Trad. Compl. Alt. Med.

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Dysmenorrhea is painful menstrual cramps, which negatively impacts the quality of life of a large percentage of the world's female population in reproductive age. The paper reviews the plants used in the Malian traditional medicine for the treatment of dysmenorrhea. Some medicinal plants were effective for treatments of dysmenorrhea with minimal side effects. Conventional therapy for dysmenorrhea, which usually includes non-steroidal anti-inflammatory drugs (NSAIDs), provides symptomatic relief, but presents increasing adverse effects with long-term use. This article is in the framework of a study supported by International Foundation for Science (IFS) on three medicinal plants used in the treatment of dysmenorrhea in Mali: Maytenus senegalensis Stereospermum kunthianum and Trichilia emetica. Keywords: Dysmenorrhea; Maytenus senegalensis; Stereospermum kunthianum; Trichilia emetica; Mali PLANTES MÉDICINALES TRADITIONNELLEMENT UTILISÉES AU MALI POUR LA DYSMÉNORRHÉE. Résumé:La dysménorrhée est une crampe menstruelle douloureuse qui influe négativement sur la qualité de vie d'un grand pourcentage de la population féminine mondiale en âge de procréer. Le document passe en revue les traitements en médecine traditionnelle malienne de la dysménorrhée par l'utilisation de diverses plantes médicinales. Certaines plantes médicinales sont efficaces pour les traitements de la dysménorrhée avec des effets secondaires minimes. Le traitement conventionnel de la dysménorrhée comprend généralement les anti-inflammatoires non stéroïdiens (AINS) qui soulagent des symptômes. Cependant leur l'utilisation à long terme engendre des effets néfastes. Le présent travail qui est financé par la FIS porte sur trois des plantes les plus employées dans le traitement traditionnel de la dysménorrhée au Mali :Maytenus senegalensis, Sterospermum kunthianum et Trichilia emetica.

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“…Members of this genus are important not only in terms of experimentally observed biological activities, 6 but also because they are used in folk medicine for gastric diseases, 7 and as antiseptic, anti-asthmatic, anti-tumor, 8 antiviral, 9 and anti-inflammatory agents. 10 In a recent review, Niero et al 11 provided an adequate description of the ethnopharmacological, chemical and pharmacological knowledge about species of the genera Maytenus, with particular emphasis on those growing in Brazil. Many species of this genus are effective medicines, and represent promising sources of bioactive substances of medicinal interest.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Rodrigues¹,

Duarte²,

Silva³

et al. 2012

Quím. Nova

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Recebido em 3/10/11; aceito em 26/2/12; publicado na web em 2/7/12The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1 H and 13 C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.

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Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid

Cited by 51 publications

References 21 publications

Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology

Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology

Medicinal Plants Traditionally Used In Mali for Dysmenorrhea

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

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