Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of &lt;i&gt;Citrus sinensis&lt;/i&gt; peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats

Osarumwense, P.O.

doi:10.4314/jasem.v21i6.37

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…Recently, the anti-inflammatory effect of Citrus sinensis peels' hydroalcoholic and methanol extracts was confirmed by Osarumwense et al (2017). Interestingly, methanol extract was more active than hydroalcoholic extract, and a positive control drug (Indomethacin) with an inhibition of 95% on carrageenan induced rat paw edema at a concentration of 40 mg/kg.…”

Section: Anti-inflammatory Activitymentioning

confidence: 96%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Anti-inflammatory Activitymentioning

confidence: 96%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…The antibacterial activity evaluation of the present study showed promising antibacterial activity by ethanol extracts of the peels of C. sinensis against K. pneumonia and E. faecalis, compound 1 against K. pneumonia, compound 2 against P. aeruginosa and K. pneumoni, and compound 4 against S. typhimurium, E. coli and P. aeruginosa and this finding agrees with previous studies by Baba et al (2018). Previous studies by Osarumwense (2017) revealed that the methanolic extract of C. sinensis peel is highly active against Gram positive, Gram negative bacteria and fungi at concentrations of 100 mg/mL, 150 mg/mL and 200mg/mL, respectively. Similarly, a related study by Omodamiro and Jamoh (2014) suggested that ethanolic extracts at different concentrations (250, 125, 62.5, 31.25, and 15.5 mg/mL) exhibited antibacterial activity against S. aureus, S. pneumoniae, E. coli, P. mirabilis and P. aeruginosa, in a dose-dependent manner.…”

Section: Antibacterial Activity 351 In Vitro Antibacterial Activitymentioning

confidence: 99%

Antibacterial and antioxidant activity of compounds from Citrus sinensis peels and in silico molecular docking study

YOHANES,

GEREMEW,

TAFESE

et al. 2023

International Journal of Secondary Metabolite

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The increasing prevalence of drug resistance, adverse side effects of existing antibiotics, and the resurgence of previously known infections have necessitated the search for new, safe, and effective antimicrobial agents. The peels of Citrus sinensis (300 g) were extracted using maceration and ultrasonic-assisted extraction methods with ethanol, resulting in yields of 20.99 g and 11.5 g (7%, 7.5%), respectively. Silica gel column chromatographic separation of the ethanol extract yielded N-(1,3,4,5-tetrahydroxydecan-2-y1)octanamide (1), decanoic acid (2), β-sitosterol-3-O-β-D-glucopyranoside derivative (3), and (z)-ethyl tetradec-7-enoate (4). GC-MS analysis of the essential oil detected 7 chemical components accounting for 99.84% of the total composition of which limonene was found to be the predominant constituent (87.5%). In vitro antibacterial tests revealed promising zones of inhibition by ethanol extract (12.67±0.58 mm, at 150 mg/mL), compound 4 (15.67±2.88 mm, at 6 mg/mL), and compound 1 (12.00±0.00 mm, at 6 mg/mL) against E. faecalis, S. typhimurium, and P. aeruginosa, respectively, compared to gentamicin (13.00±1.73 mm, 18.00±1.00 mm, and 16.67±1.15 mm, respectively at 10 µg/mL). DPPH radical scavenging activity indicated that compound 1 exhibited an IC50 value of 0.05 mg/mL, compared to ascorbic acid's 0.016 mg/mL. In silico molecular docking studies revealed that compounds 1 and 3 had the lowest scoring poses against E. coli DNA gyrase B enzyme, human peroxiredoxin 5, and S. aureus pyruvate kinase, respectively. These findings support traditional applications of Citrus peels in treating infectious diseases, particularly against Gram-positive strains, and highlight their potential use as antibacterial ingredients in cosmetics.

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“…Antimicrobial activity of P. granatum fruit peels was also reported by Al-Zoreky (2017). Antiinflammatory activity was reported from peels of Citrus sinensis (Osarumwense, 2017), Citrus grandis (Zhao et al, 2019), Punica granatum (Mastrogiovanni et al, 2019) and Ziziphus jujuba (Wang et al, 2019). Citrus grandis peels were rich in coumarins; Punica granatum peels were rich in high molecular weight phenols like alpha and beta punicalagin and low molecular weight phenols like gallic acid, ellagic acid and granatin B; Ziziphus jujuba contained phenolics like quercetin galangin and flavonoids.…”

Section: Issn: 2319-7706 Volume 9 Number 8 (2020)mentioning

confidence: 99%

Best from Waste: Therapeutic Potential of Plant Waste (Seeds, Peels, Flowers)

Donga¹,

Chanda²

2020

Int.J.Curr.Microbiol.App.Sci

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Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats

Cited by 5 publications

References 3 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

Antibacterial and antioxidant activity of compounds from Citrus sinensis peels and in silico molecular docking study

Best from Waste: Therapeutic Potential of Plant Waste (Seeds, Peels, Flowers)

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