Anti-Inflammatory Activity of Mono Ammonium Glycyrrhizinate Liquorice in Rheumatoid Arthritis against Complete Freunds Adjuvant Induced Arthritis in Female Albino Wistar Rats

Abstract

The present study was conducted to evaluate the potential of mono ammonium glycyrrhizinate liquorice root extract in rheumatoid arthritis and explore its possible mechanism of action. Paw and sciatic nerve samples were used to estimate total protein, catalase enzyme and GSH (Glutathione S-Transferase). Significant (p< 0.01) reduction in protein content, catalase enzyme and Reduced Glutathione (GSH) clearly indicate that mono ammonium glycyrrhizinate has anti-inflammatory property.The present study suggests that mono ammonium glycyrrhizinate shows protective activity in CFA-induced arthritis, which may be due to its improved haematological properties as well as its antioxidant and anti-inflammatory properties.