Anti-inflammatory activity of natural products (I) triterpenoids

Evaluation of the analgesic, anti‐inflammatory and anti‐diabetic properties of Sclerocarya birrea (A. Rich.) Hochst. stem‐bark aqueous extract in mice and rats

“…Since Sclerocarya birrea stem-bark is known to contain triterpenoids, flavonoids and phytosterols (in addition to other chemical compounds), it is not unlikely that these chemical compounds might have contributed to the observed analgesic, anti-inflammatory and hypoglycaemic effects of the plant's stem-bark aqueous extract. Several investigators have indeed attributed the anti-inflammatory and hypoglycaemic properties of a number of plants to their triterpenoid, coumarin and flavonoid constituents (Gupta et al, 1969;1971;Sugishta et al, 1982;Price et al, 1987;Simon et al, 1992;Singh et al, 1992;Liu, 1995;Marles and Farnsworth, 1995;Ojewole, 2002;2003). Since Sclerocarya birrea stem-bark has been widely reported to contain many chemical compounds, including polyphenols, tannins and flavonoids, sterols, triterpenoids, sesquiterpenes, ascorbic acid, oleic acid, myristic, stearic, glutamic and amino acids, and so on, it may be reasonable to speculate that the analgesic, anti-inflammatory and anti-diabetic properties of the plant extract observed in this study could be due respectively, to one or more of the above chemical constituents of the plant.…”

Hepatoprotective activity in the rat of ursolic acid isolated from eucalyptus hybrid

“…Ursolic acid is reported to produce a wide variety of pharmacological activities including antiinflammatory (Gupta et al, 1969), antiulcer (Gupta et al, 1981) and cytotoxic (Lee et al, 1988) effects. A brief report on its hepatoprotective activity has also appeared .…”

Analgesic and antiinflammatory effects of mollic acid glucoside, a 1α‐hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf

“…This hypothesis is in consonance with the observations of Eddy and Leimback (1953), and Williamson et al (1996) who proposed that the 'hot-plate' and 'acetic acid' analgesic test methods are useful techniques for evaluating analgesic compounds with peripheral and central actions, respectively. Certain triterpenoid saponins, sapogenins and other groups of chemical compounds have been reported to possess analgesic and antiinflammatory properties in experimental animal models (Gupta et al, 1969;Ekpendu et al, 1994;Hutchings et al, 1996;Adzu et al, 2003;Dongmo et al, 2003;Ojewole, 2003;Taesotiku et al, 2003). It is not unlikely that mollic acid, a…”