Anti-Inflammatory Activity of Piperonyl-4-Acrylic Isobutyl Amide, an Extractive from Zanthoxylum zanthoxyloides

Oriowo, Mabayoje A.

doi:10.1055/s-2007-971402

Cited by 58 publications

(41 citation statements)

References 3 publications

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“…By this action, NSAIDs reduce the sensitization of afferent neurons by prostaglandins to the algesic actions of bradykinin and other pain provoking stimuli. As isolated and purified alkaloids of the root bark of Z. xanthoxyloids also have anti-prostaglandin synthetase activity 2 , it is most likely that the extract, like indomethacin and other NSAIDs, might induce analgesia by inhibiting the production and release of prostaglandins or blocking their receptors.…”

Section: Discussionmentioning

confidence: 99%

“…The extract is also used as an antiseptic. 1 Isolated and purified alkaloids of the root bark, namely, 3, 4-dihydro-2-diurethyl-2H-1-benzopyran-6-butyric acid (DBA), a benzopyran butyric acid derivative of zanthoxylol and piperonyl-4-acrylic isobutylamide (fagaramide) 2 , have been identified to have antiprostaglandin synthetase activity as well as antiinflammatory activity, using plethysmometry method. The former activity, which is responsible for inhibition of prostaglandin synthesis, contributes to the antiinflammatory activity of fagaramide.…”

Section: Introductionmentioning

confidence: 99%

“…The plethysmometry method 2 established the antiinflammatory activity but not the analgesic activity of fagaramide. Since the extract is used mainly as analgesic agent, investigation into the effect of the extract on pain threshold became particularly relevant.…”

Section: Introductionmentioning

confidence: 99%

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Analgesic activity of crude aqueous extract of the root bark of zanthoxylum xanthoxyloides

Prempeh¹

2009

Ghana Medical Journal

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SUMMARYObjective: The analgesic activity of crude aqueous extract of the root bark of Zanthoxylum xanthozyloides was studied in mice and rats with the view to verifying the claim in folklore medicine that the extract has analgesic activity. Method: The extract was obtained by Soxhlet extraction and rotatory evaporation, followed by freezedrying. Groups of rats and mice were, respectively, assigned randomly to treatment groups. The animals received three different treatments orally: 0.9% saline (control), the extract (400mg/kg and 800mg/kg for mice; 1000mg/kg and 2000mg/kg for rats) and indomethacin (5mg/kg and 10mg/kg for mice; 10mg/kg and 20mg/kg for rats). Each group of animals was rotated through the entire treatment groups such that each animal served as control as well as received all the treatments. The hot-plate and paw-pressure methods were used to study pain perception in the treated animals. Analysis of variance was used as the statistical test. Results: In both methods, the extract and indomethacin caused dose-dependent elevation in pain threshold. At the peak of activity, 400mg/kg and 800mg/kg extract caused 74% and 95% increase in the reaction time respectively whilst 5mg/kg and 10mg/kg indomethacin gave 97% and 116% increment respectively. Similarly, 1000mg/kg and 2000mg/kg extract caused 65% and 84% increase in pain threshold whilst 10mg/kg and 20mg/kg indomethacin caused 95% and 113% increment respectively. Conclusion: It was concluded that the extract induced analgesia, probably, by inhibiting prostaglandin production, just as did indomethacin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analgesic activity of crude aqueous extract of the root bark of zanthoxylum xanthoxyloides

Prempeh¹

2009

Ghana Medical Journal

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“…In a decade, Zanthoxylum plants and their active constituents have been widely explored for their anti-inflammatory potentials using in vitro and in vivo experiments. For example, crude aqueous extract of the root bark of Z. xanthoxyloides demonstrated consistently anti-inflammatory activities via decreasing the production of PGE 2 subsequent to inhibition of COX-2 in inflammatory culture cells in vitro and carragenin-induced inflammation in rats (Oriowo, 1982;Prempeh and Mensah-Attipoe, 2008a;2008b). Recently, a phytoglycoprotein with molecular weight of 115 kD isolated from Z. piperitum DC.…”

Section: Effects Of Lpfe On the Protein And Gene Expression Of Inflammentioning

confidence: 99%

Lemon Pepper Fruit Extract (<i>Zanthoxylum acanthopodium</i> DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages <i>In Vitro</i>

Yanti¹,

Pramudito²,

Nuriasari³

et al. 2011

American Journal of Biochemistry and Biotechnology

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Problem statement: Lemon pepper fruits (Zanthoxylum acanthopodium DC.; Rutaceae) have been used as a traditional source against stomach ache by Batak people in North Sumatera province, Indonesia. However, its scientific evidence for treatment of inflammatory disorders particularly gastritis has not been reported. Approach: Here, we investigated the inhibitory effects of Lemon Pepper Fruit Extract (LPFE) against inflammatory biomarkers by conducting cell culture experiments in vitro. The fruits of lemon pepper were dried and extracted twice in 70% ethanol, followed by evaporation and freeze-drying. The concentrated extract was further tested for its potential inhibition on the protein and gene expression of several inflammatory biomarkers, i.e. ) and LPS (2 µg mL −1 ) had no cytotoxicity effects on macrophages. LPFE dose dependently decreased the expression of TNF-α and COX-2 proteins and MMP-9 activity in macrophages treated with LPS. At the gene level, LPFE were effectively found to block the mRNA expression of TNF-α, IL-6, iNOS, COX-2 and MMP-9. Conclusion: Our results suggest that LPFE significantly inhibits selected inflammatory biomarkers at the protein and gene levels in LPS-induced macrophages. Further in vivo study using animal models is needed to determine the exact anti-inflammatory potential of LPFE.

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“…The anti-inflammatory activity of fagaramide, isolated from the plant ma_ terial, has been shown (Oriowo, 1982) XXXVl Hydroxy benzoic acids from Ζ. zanthoxyloides.…”

Section: Seellaneousmentioning

confidence: 99%

Chemical and biological investigations on medicinal plants of west Africa

Olaniyi

1988

Acta Amaz.

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Anti-Inflammatory Activity of Piperonyl-4-Acrylic Isobutyl Amide, an Extractive from Zanthoxylum zanthoxyloides

Cited by 58 publications

References 3 publications

Analgesic activity of crude aqueous extract of the root bark of zanthoxylum xanthoxyloides

Analgesic activity of crude aqueous extract of the root bark of zanthoxylum xanthoxyloides

Lemon Pepper Fruit Extract (<i>Zanthoxylum acanthopodium</i> DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages <i>In Vitro</i>

Chemical and biological investigations on medicinal plants of west Africa

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