Anti-Inflammatory Activity of Pluchea lanceolata: Isolation of an Active Principle

Srivastava, V.K.; Varma, Neeraj; Tandon, J. S.; Srimal, R. C.

doi:10.3109/13880209009082796

Cited by 20 publications

(12 citation statements)

References 2 publications

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“…It is also used as antipyretic, analgesic, bitter, laxative, and nervine tonic (Chopra et al, 1958) in Ayurveda. The drug has been scientifically validated for certain pharmacological effects namely antiinflammatory (Prasad et al, 1966;Srivastava et al, 1990), uterine relaxant (Jadhav & Bhutani, 2005) and antioxidant effects. A number of phytoconstituents, α-amyrin, β-amyrin caproate, stigmasterol (Bhatnagar et al, 1972) few triterpenes morentenol acetate, morentenol, neolupenol (Chawla et al, 1991;Kaith, 1995), Ψ taraxasterol acetate (Ames et al 1954;Srivastava et al, 1990), quercetin and isorhamnetin (Bahl et al, 1968) have been isolated from the plant.…”

Section: Introductionmentioning

confidence: 99%

A report on the quality control parameters of aerial parts of Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae

Khan¹,

Rawat²,

Rawat³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Relatório sobre os parâmetros de controle de qualidade das partes aéreas de Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae." Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae, é uma planta que tem sido usada como medicinal na Índia como um antipirético, analgésico anti-reumático e calmante. Este trabalho tem como objetivo estabelecer os padrões morfológicos e anatômicos e caracterizar o extrato(s) de P. lanceolata pela triagem fitoquímica preliminar como parâmetro de controle de qualidade para a matéria-prima.Unitermos: Pluchea lanceolata, controle de qualidade, físico-química, microscopia, fluorescência.ABSTRACT: Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae, is a weed that has been used as an indigenous medicine in India as an antipyretic, analgesic, anti-rheumatic and nervine tonic. This paper aims at setting the morphological and anatomical standards and to characterize the extract(s) of P. lanceolata by preliminary phytochemical screening as quality control parameter for the raw material.

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Section: Introductionmentioning

confidence: 99%

A report on the quality control parameters of aerial parts of Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae

Khan¹,

Rawat²,

Rawat³

et al. 2010

Rev. bras. farmacogn.

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“…Quercetin and isorhamentin are present as aglycones in the leaves of P. lanceolata. Glycosides and tannins were absent (Srivastava et al 1990).…”

Section: Introductionmentioning

confidence: 99%

Pluchea lanceolata attenuates cadmium chloride induced oxidative stress and genotoxicity in Swiss albino mice

Jahangir

Khan

Prasad

et al. 2005

Journal of Pharmacy and Pharmacology

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Cadmium intoxication induces lipid peroxidation and causes oxidative damage to various tissues by altering antioxidant defence system enzymes. At 24 h after treatment with a single intraperitoneal dose of cadmium chloride (5 mg kg-1), Swiss albino mice showed a significant increase in the levels of malanodialdehyde and xanthine oxidase (P<0.001), and a concomitant depletion of renal glutathione, catalase (P<0.001) and other antioxidant enzymes. CdCl2 also led to a simultaneous increase in micronuclei formation (P<0.001) and chromosomal aberrations (P<0.05) in mouse bone marrow cells. Oral pre-treatment with Pluchea lanceolata extract at doses of 100 and 200 mg kg-1 for 7 consecutive days before CdCl2 intoxication caused a significant reduction in malanodialdehyde formation and xanthine oxidase activity (P<0.001). A significant restoration of the activity of antioxidant defence system enzymes such as catalase, glutathione peroxidase (P<0.05), glutathione-S-transferase and glutathione reductase (P<0.001) was observed. A significant dose-dependent decrease in chromosomal aberrations and micronuclei formation was also observed (P<0.05). The results indicate that pre-treatment with P. lanceolata attenuates cadmium chloride induced oxidative stress and genotoxicity by altering antioxidant enzymes and reducing chromatid breaks and micronuclei formation.

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“…A study by Vandita Shrivastawa et.al on ethanolic extract of Rasna exhibited significant anti-inflammatory activity. 26 A new quaternary base chloride called pluchine was isolated from Pluchea lanceolata. This substance harbours smooth muscle relaxing, spasmolytic and anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy/Safety of Therapeutic Combination;Kshirbala Taila Matra Basti, Vatari Guggulu, Maharasnadi KwathaandNarayan Tailain the Management of Osteoarthritis Knee (Sandhivata): A Prospective Open Label Study

Lnu¹,

Namburi²

2018

Journal of Research in Ayurvedic Sciences

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Introduction: Osteoarthritis (OA) knee is the most frequent joint disease encountered in the clinical practice and a leading cause of disability in the elderly. It is a chronic degenerative disorder of multi-factorial etiology characterized by loss of articular cartilage, hypertrophy of bone at the margins, subchondral sclerosis and range of biochemical and morphological alterations of the synovial membrane and joint capsule. The clinical presentation of OA is similar to Sandhivata described under Vatavyadhi in Ayurveda.

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Anti-Inflammatory Activity of Pluchea lanceolata: Isolation of an Active Principle

Cited by 20 publications

References 2 publications

A report on the quality control parameters of aerial parts of Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae

A report on the quality control parameters of aerial parts of Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae

Pluchea lanceolata attenuates cadmium chloride induced oxidative stress and genotoxicity in Swiss albino mice

Clinical Efficacy/Safety of Therapeutic Combination;Kshirbala Taila Matra Basti, Vatari Guggulu, Maharasnadi KwathaandNarayan Tailain the Management of Osteoarthritis Knee (Sandhivata): A Prospective Open Label Study

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