Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

Rogério, Alexandre de Paula; Kanashiro, Alexandre; Fontanari, Caroline; Silva, E. V. G. da; Lucisano-Valim, Yara Maria; Soares, Edson García; Faccioli, Lúcia Helena

doi:10.1007/s00011-007-7005-6

Cited by 289 publications

(178 citation statements)

References 48 publications

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“…41 Additionally, the anti-inflammatory role of quercetin and isoquercetin in HBE in inhibiting inducible nitric oxide synthease and cyclooxygenase II in stimulated macrophages has been reported. 42,43 Statins are other anti-inflammatory medicines that may be indicated in the treatment of colitis. The anti-inflammatory and antioxidative effects of atorvastatin were evaluated and compared with HBE for decreasing the colon MPO activity, TTM levels, TBARS content, and AA-induced pathological damage.…”

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confidence: 99%

Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats

Malekinejad

Shafie-Irannejad

Hobbenaghi

et al. 2013

Journal of Medicinal Food

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The protective effect of hydroalcoholic extract of hawthorn berries (HBE) on acetic acid (AA)-induced colitis in rats was investigated. Forty-two Wistar rats were divided into seven groups, including control and test groups (n = 6). The control animals received saline, and the test animals were treated with saline (sham group), mesalamine (50 mg/kg; M group), atorvastatin (20 mg/kg; A group), HBE (100 mg/kg; H group), mesalamine and HBE (HM group), or atorvastatin plus HBE (HA group), 3 days before and a week after colitis induction. Colitis was induced by administration of 1 mL AA (4%) via a polyethylene catheter intrarectally. High-performance liquid chromatography analyses showed that HBE contained 0.13% and 0.5% oleanolic acid and ursolic acid, respectively. Elevated myeloperoxidase activity and lipid peroxidation were attenuated in the HA group. The H and HM groups showed marked reductions in colitis-induced decreases in total thiol molecules and body weight. The histopathological studies revealed that HBE decreased colitis-induced edema and infiltration of neutrophils. Our data suggest the anti-inflammatory and antioxidant effects of HBE and atorvastatin protect against AA-induced colitis. The anti-inflammatory effect of HBE may be attributable to its ability to decrease myeloperoxidase activity as a biomarker of neutrophil infiltration.

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mentioning

confidence: 99%

Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats

Malekinejad

Shafie-Irannejad

Hobbenaghi

et al. 2013

Journal of Medicinal Food

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“…From the flavonoid glycosides determined in the current study, astragalin (Lee et al, 2011), isoquercitrin (Rogerio et al, 2007), nicotiflorin (Soberon et al, 2010) and rutin (Lee et al, 2015), as well as chlorogenic acids (Liang and Kitts, 2016) have been previously stated as demonstrating anti-inflammatory activity.…”

Section: Anti-inflammatory Activitymentioning

confidence: 69%

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Svobodová

Barros

Calhelha

et al. 2017

Industrial Crops and Products

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a b s t r a c tA wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, ␤-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC 50 = 10-0.625 g/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.

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“…Quercetin (Figure 1), a flavonoid widely distributed in nature, is known to have several biological effects, including anti-inflammatory (Rogerio et al 2007;Kleemann et al 2011), antiviral (Ohnishi & Bannai 2002;Choi et al 2009), and antitumor activities (Tan et al 2009;Du et al 2010), which have been described earlier. Recently, much attention has been focused on its antitumor effect.…”

Section: Introductionmentioning

confidence: 89%

Induction of apoptosis in HT-29 cells by quercetin through mitochondria-mediated apoptotic pathway

Gao

2013

Animal Cells and Systems

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With increasing use of natural plant-derived components, exploring the anti-proliferative effects of phytochemicals is increasingly gaining importance in designing anticancer drugs. Quercetin, a natural constituent abundantly present in food products, is capable of inducing apoptosis in tumor cells. However, little is known about its biological effect on colon cancer cells and molecular mechanism leading to this event. The aim of this study was to investigate the effect of quercetin on the apoptotic pathway in human colon carcinoma cells (HT-29 cells). The results indicated that quercetin induced suppression of cell viability and apoptosis in HT-29 cells in a dose-dependent manner. This involved characteristic changes in nuclear morphology, activation of caspases-3 and caspases-9, collapse of Mitochondrial membrane potential (DCm), upregulation of pro-apoptotic Bax, and downregulation of antiapoptotic Bcl-2 and Bcl-XL. Quercetin, which exerts anti-proliferative effect though different signaling pathways, is a classic candidate for anti-colon cancer drug design.

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Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

Abstract: Quercetin and isoquercitrin are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies.

Cited by 289 publications

References 48 publications

Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats

Comparative Protective Effect of Hawthorn Berry Hydroalcoholic Extract, Atorvastatin, and Mesalamine on Experimentally Induced Colitis in Rats

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Induction of apoptosis in HT-29 cells by quercetin through mitochondria-mediated apoptotic pathway

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