Anti-Inflammatory Activity of Raphanus sativus L in Acute and Chronic Experimental Models in Albino Rats

Kamble, Shobha; Ahmed, Zubair; Ramabhimaiaha, S.; Patil, Prabhakar

doi:10.13005/bpj/420

Cited by 11 publications

(11 citation statements)

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“…27 The TME extract of C. inerme showed anti-inflammatory activity more than indomethacin at dose 200 mg/kg after 4 h ( Table 2). That may be due to the presence of flavonoids, terpenes, and sterols and also due to inhibition of main inflammatory mediators like histamine, serotonin, prostaglandins, bradykinin, angiotensin, tachykinin, platelet activating factor, and substance-P. 28 Our results show that C. inerme exerts significant inhibitory effects on nociceptive response of the late phase of the chemical and inflammatory pain model in formalin test. The presence of flavonoids in C. inerme may modify the action or production of free radicals and nitrogen reactive species.…”

Section: Discussionmentioning

confidence: 52%

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme

Ibrahim

Alshali

Fouad

et al. 2014

Bulletin of Faculty of Pharmacy, Cairo University

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B-friedoolean-5-ene-3-b-ol (1), b-sitosterol (2), stigmasta-5,22,25-trien-3-b-ol (3), betulinic acid (4), and 5-hydroxy-6,7,4 0 -trimethoxyflavone (5) were isolated from the aerial parts of Clerodendrum inerme L. (Verbenaceae). Their structures were established based on analyses of physical and spectroscopic data. Compounds 1, 4, and 5 were isolated for the first time from the plant. C. inerme L. was known as a rich source of terpenes, sterols, and phenolic compounds, so the antioxidant and anti-inflammatory activities were evaluated. The total methanolic extract (TME) and compound 5 showed scavenging activity with maximum inhibition of 61.84% for TME (100 lg/mL) and 37.19% for 5 (20 lM), respectively, using DPPH assay. In addition, the TME exhibited anti-inflammatory activity more than indomethacin at dose 200 mg/kg using the formalin induced hind paw edema method.ª 2014 Production and hosting by Elsevier B.V. on behalf

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Section: Discussionmentioning

confidence: 52%

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme

Ibrahim

Alshali

Fouad

et al. 2014

Bulletin of Faculty of Pharmacy, Cairo University

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“…The phytochemical study of the EtOAc fraction led to isolation of six-known compounds: 3-(E)-(methylthio)methylene-2-pyrrolidinethione (1), ascorbigen (2), β-sitosterol (3), palmitic acid (4), α-linolenic acid (5), and 1-linoleonyl glycerol (6). The phytochemical study of the EtOAc fraction led to isolation of six-known compounds: 3-(E)-(methylthio)methylene-2-pyrrolidinethione (1), ascorbigen (2), β-sitosterol (3), palmitic acid (4), α-linolenic acid (5), and 1-linoleonyl glycerol (6).…”

Section: Resultsmentioning

confidence: 99%

Antimelanogenic Effects of Raphanus sativus L. var. niger Roots on α‐MSH Stimulated B16F10 Melanoma Cells

Kim

et al. 2018

Bulletin Korean Chem Soc

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This study was conducted to identify the antimelanogenic components from Raphanus sativus L. var. niger (black radish). Phytochemical study with the ethanol extract of black radish roots resulted in the isolation of six compounds: 3-(E)-(methylthio)methylene-2-pyrrolidinethione (1), ascorbigen (2), β-sitosterol (3), palmitic acid (4), α-linolenic acid (5), and 1-linoleonyl glycerol (6). Among the isolates, the thione 1 efficiently inhibited melanin synthesis in a concentration-dependent manner in α-MSH stimulated B16F10 melanoma cells. Western blotting analysis for the key melanogenic enzymes showed that compound 1 decreased tyrosinase and tyrosinase-related protein-2 expressions. These results demonstrated that the black radish extract including pyrrolidinethione 1 could be useful as antimelanogenic agents in cosmetic or pharmaceutical applications.

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“…An uncontrolled and persistent inflammation may cause chronic illnesses. 18 NSAIDs are used to control and treat inflammation. They are heterogeneous class of drugs like aspirin, indomethacin, diclofenac, nimesulide, celecoxib etc., which act by inhibiting COX (COX-1 and COX-2 nonselectively or COX-2 selectively) enzyme.…”

Section: Discussionmentioning

confidence: 99%

“…They are heterogeneous class of drugs like aspirin, indomethacin, diclofenac, nimesulide, celecoxib etc., which act by inhibiting COX (COX-1 and COX-2 nonselectively or COX-2 selectively) enzyme. 6,18,19 COX is the rate-limiting enzyme responsible for the production of PGs, prostacyclins and thromboxanes. Inflammatory chemicals like endotoxin, mitogens and cytokines, especially IL-1 induce COX-2 biosynthesis and is responsible for production of enhanced PGs in inflamed tissues.…”

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats

Murthy

Srinivas

Shanthi

2018

Int J Basic Clin Pharmacol

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Background: NSAIDS are associated with side effects and research should continue for developing safer drugs. This study aims to evaluate newer thiazolidine-4-ones for their anti-inflammatory and ulcerogenic activities in wister rats.Methods: Five groups of wister rats, 6 in each were used. Anti-inflammatory and ulcerogenic activities of diclofenac (30mg/kg), nimesulide (50mg/kg), thia-1 (50mg/kg) and thia-2 (50mg/kg) are compared with control group (4% Gum Acacia). Carrageenin-induced paw edema, formaline induced acute peritonitis and cotton pellet-induced granulomatous tissue formation models were used for evaluating anti-inflammatory activity. After removing cotton pellets with granuloma on 8th day gastric ulcerogenicity was assessed by using macroscopic and microscopic scoring of ulcers.Results: Diclofenac, nimesulide and thia 2 reduced both paw edema and peritoneal exudate volume significantly (p <0.01). Wet weight of cotton pellets reduced significantly (p <0.01) by diclofenac, nimesulide and thia 2. Diclofenac (p <0.01) and thia 2 (p <0.05) reduced dry weight of cotton pellets significantly. nimesulide and thia-1 reduced it by 19.14% and 2.68% respectively and was considered statistically not significant (p>0.05). Nimesulide, thia-1 and thia-2 did not increase gastric ulcer score significantly (p >0.05). Diclofenac increased ulcer score significantly (p <0.01).Conclusions: Thia-2 demonstrated significant anti-inflammatory activity in acute and chronic models. In addition to inhibition of cyclooxygenase pathway, PPAR agonistic activity may be involved in its anti-inflammatory activity. No significant ulcerogenicity was observed on comparing with nimesulide and control. Further in-vitro and in-vivo studies are recommended to confirm the results of this study.

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Anti-Inflammatory Activity of Raphanus sativus L in Acute and Chronic Experimental Models in Albino Rats

Cited by 11 publications

References 0 publications

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme

Antimelanogenic Effects of Raphanus sativus L. var. niger Roots on α‐MSH Stimulated B16F10 Melanoma Cells

Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats

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