Anti-Inflammatory Activity of Sesquiterpene Lactones and Related Compounds

Hall, Iris H.; Lee, K.H.; Starnes, C.O.; Sumida, Yoichi; Wu, Rong-Yang; Waddell, Thomas G.; Cochran, J.W.; Gerhart, Karl

doi:10.1002/jps.2600680505

Cited by 180 publications

(89 citation statements)

References 39 publications

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“…29 The a-methylene-g-lactone group has been shown to be responsible for some of the biological effects of parthenolide. 30 To investigate the role of this functional group in the suppression of Myb activity, we compared the inhibitory …”

Section: Resultsmentioning

confidence: 99%

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

et al. 2011

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Section: Resultsmentioning

confidence: 99%

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

et al. 2011

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“…Sesquiterpene lactones are isolated from extracts of Mexican-Indian plants and have been widely used in indigenous medical practices, including treatment of migraines [4,5], inflammation [6], stomachache, toothache, menstrual irregularities, fever and rheumatoid arthritis [7]. Parthenolide is the principal component of sesquiterpene lactones present in medical plants such as feverfew (Tanacetum parthenium) [8].…”

Section: Parthenolide -Multifunctional Naturally Derived Compoundmentioning

confidence: 99%

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

Pająk

Gajkowska²,

Orzechowski³

2008

Folia Histochem Cytobiol.

126

133

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This review outlines the molecular events that accompany the anti-tumor action of parthenolide (PN). Parthenolide (PN) is naturally derived compound, isolated from plant Tanacetum parthenium. PN has been previously shown to withdraw cells from cell cycle or to promote cell differentiation, and finally to induce programmed cell death. Recent advances in molecular biology indicate that this sesquiterpene lactone might evoke the above-mentioned effects by indirect action on genes. PN was shown to inhibit NF-κB-and STATs-mediated antiapoptotic gene transcription. On one hand, the proapoptotic activity of PN includes stimulation of intrinsic apoptotic pathway with the higher level of intracellular ROS and modifications of Bcl-2 family proteins (conformational changes of Bak and Bax, Bid cleavage). On the other hand, PN amplifies the apoptotic signal through the sensitization of cancer cells to extrinsic apoptosis, induced by TNF-α. These effects are specific to tumor cells. Unique properties of PN make this agent a promising metabolic inhibitor to retard tumorigenesis and to suppress tumor growth.

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“…Parthenolide (PTL) is a multifunctional naturally occurring compound, isolated from Mexican Indian asteraceae family plants and has been widely used in native folk medical practices, including treatment of inflammation [1], stomach ache, tooth ache, menstrual irregularities, fever, rheumatoid arthritis [2] and migraines [3,4] due to its anti-inflammatory properties [5]. Sesquiterpene lactones are secondary metabolites found in asteraceae family plants.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and Anti-tumor Activities of Parthenolide: An Update

Dey¹,

Sarkar²,

Giri³

2016

J Chem Biol Ther

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Parthenolide (PTL), the secondary metabolite of feverfew plant (Tanaceum parthenium), has been used in various medical purposes globally. Inflammation represents a physiological response to injury and helps to restore tissue homeostasis. Inflammation and cancer both are associated with genotoxicity, invasion, metastasis, and abnormal tissue repair mechanisms. PTL inhibit major cellular inflammatory and proliferation pathways like NFκB, STAT3, and MAPK along with the activity and expression of several inflammatory mediators including COX. NFκB pathway plays a key role in controlling cell cycle progression and apoptosis together with metastasis and cancer of various types. Elevated NFκB, Wnt/β-catenin pathways are crucial factors of tumorogenesis. PTL inhibits NFκB and Wnt/β-catenin pathways, and thereby promotes apoptosis and suppresses cell proliferation. Experimental data showed that PTL protects normal cells from apoptosis; whereas in cancer cells it induces apoptotic cell death. Hence, parthenolide could be useful in controlling inflammatory diseases alone or together with tumorogenesis due to its evident anticancer potency and anti-inflammatory nature.

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Anti-Inflammatory Activity of Sesquiterpene Lactones and Related Compounds

Cited by 180 publications

References 39 publications

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

Anti-inflammatory and Anti-tumor Activities of Parthenolide: An Update

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