Anti-inflammatory Activity of Some Essential Oils

G, Salud Pérez; Zavala, S Miguel; Arias, G Lucina; Ramos, Luciane

doi:10.1080/10412905.2011.9700480

Cited by 77 publications

(39 citation statements)

References 40 publications

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“…Some plant constituents, particularly alcohol terpenoids (geraniol and citronellol), have been reported to be useful in the management of inflammatory processes (23–26). Our results are in agreement with those reported in the literature for other EOs rich in monoterpenic alcohol and showing a very strong anti-inflammatory effect.…”

Section: Resultsmentioning

confidence: 99%

Rose geranium essential oil as a source of new and safe anti-inflammatory drugs

Boukhatem

Kameli

Ferhat

et al. 2013

Libyan Journal of Medicine

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BackgroundSince the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries.AimsThe aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO).MethodsThe chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses.ResultsRGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin.ConclusionOur results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile.

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Section: Resultsmentioning

confidence: 99%

Rose geranium essential oil as a source of new and safe anti-inflammatory drugs

Boukhatem

Kameli

Ferhat

et al. 2013

Libyan Journal of Medicine

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“…In a study of an essential oil extract from Aster spathulifolius, whose major component included germacrene D, dose-dependent suppression of the synthesis of both TNF- α and NO was observed, and it was thus recommended for cosmetic use owing to its anti-inflammatory effects [ 45 ]. In another study, an essential oil (LD 50 , 2.50 g/kg) with germacrene D as the main constituent inhibited writhing induced by acetic acid at a dose of 200 mg/kg in formalin test [ 47 ].…”

Section: Methodsmentioning

confidence: 99%

Ethnopharmacological Potential of Aspilia africana for the Treatment of Inflammatory Diseases

Okello

Lee

Kang

2020

Evidence-Based Complementary and Alternative Medicine

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Inflammatory diseases are major health concerns affecting millions of people worldwide. Aspilia africana has been used for centuries by many African communities in the treatment of a wide range of health conditions, including inflammatory diseases, osteoporosis, rheumatic pains, and wounds. Analysis of the phytochemical composition of A. africana indicated that the plant is rich in a broad range of secondary metabolites, including flavonoids, alkaloids, tannins, saponins, terpenoids, sterols, phenolic compounds, and glycosides. This explains the efficacy of the plant in treating inflammation-related diseases, as well as several other health conditions affecting different African communities. The mechanisms of action of the anti-inflammatory phytochemical compounds in A. africana include inhibition of a number of physiological processes involved in the inflammatory process and synthesis or action of proinflammatory enzymes. The phytochemicals enhance anti-inflammatory biological responses such as inhibition of a number of chemical mediators including histamine, prostanoids and kinins, 5-lipoxygenase. and cyclooxygenase and activation of phosphodiesterase and transcriptase. Currently used anti-inflammatory medications are associated with several disadvantages such as drug toxicity and iatrogenic reactions, thereby complicating the treatment process. The adverse effects related to the use of these conventional synthetic drugs have been the driving force behind consideration of natural remedies, and efforts are being made toward the development of anti-inflammatory agents based on natural extracts. A. africana is rich in secondary metabolites, and its use as a traditional medicine for treating inflammatory diseases has been validated through in vitro and in vivo studies. Therefore, the plant could be further explored for potential development of novel anti-inflammatory therapeutics.

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“…In line with this assumption, some studies have showed that the anti-inflammatory activity of pure compounds (such as amentoflavone, pseudohypericin, and hyperforin, isolated from extracts of Hypericum perforatum ) is higher than that of the extracts [38]. In addition to plant extracts, essential oils [39,40], plant juices [41] and plant powders [42] are also widely used for medicinal purposes.…”

Section: Active Anti-inflammatory Plant Extracts Essential Oils mentioning

confidence: 99%

Anti-Inflammatory Activity of Natural Products

Azab¹,

2016

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Abstract:This article presents highlights of the published literature regarding the anti-inflammatory activities of natural products. Many review articles were published in this regard, however, most of them have presented this important issue from a regional, limited perspective. This paper summarizes the vast range of review and research articles that have reported on the anti-inflammatory effects of extracts and/or pure compounds derived from natural products. Moreover, this review pinpoints some interesting traditionally used medicinal plants that were not investigated yet.

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Anti-inflammatory Activity of Some Essential Oils

Cited by 77 publications

References 40 publications

Rose geranium essential oil as a source of new and safe anti-inflammatory drugs

Rose geranium essential oil as a source of new and safe anti-inflammatory drugs

Ethnopharmacological Potential of Aspilia africana for the Treatment of Inflammatory Diseases

Anti-Inflammatory Activity of Natural Products

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