Anti-inflammatory activity of Taraxacum officinale

Antioxidant properties ofTaraxacum officinalefruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats

“…• production in macrophage cells (Jeon et al, 2008). Two flavonoid compounds, luteolin and luteolin-7-O-glucoside, in T. officinale suppress the production of NO…”

“…• radicals in a concentrationdependent manner (Jeon et al, 2008). The DPPH • scavenging ability of the extract may be attributed to its ability to donate hydrogens.…”

“…Taraxacum officinale Weber (Asteraceae), commonly known as dandelion, has long been used for medicinal purposes due to its choleretic, diuretic, antitumor, antioxidant, antiinflammatory, antinociceptive, and hepatoprotective properties (Baba et al, 1981;Kisiel & Barszcz, 2000;Hu & Kitts, 2003;Jeon et al, 2008). Flavonoids and phenolic compounds, such as luteolin, caffeic acid, and cholorgenic acid, are found in extracts of T. officinale (Hu & Kitts, 2003;Domitrovic et al, 2010;Koh et al, 2010).…”

“…The generation of reactive oxygen species (ROS), which is a consequence of aerobic metabolism, and reactive intermediates occurs in various physiological and pathophysiological conditions (Jeon et al, 2008). Under normal conditions, ROS production is controlled by endogenous antioxidant systems present in the body that establish equilibrium between ROS and antioxidants.…”

“…As such, overproduction of ROS or inadequate antioxidant content can cause oxidative stress (Kaur et al, 2006). ROS induce lipid peroxidation, damage biomolecules, such as DNA and proteins, and affect cellular viability (Jeon et al, 2008).…”