Anti-Inflammatory Activity of Various Agents Producing Hyperlipemia in Rats

Abstract

The effect of Intralipid®, Lipofundin®, and Triton WR 1339, was studied on various models of acute inflammation. It was found that in CFY rats these agents inhibited the foot edema induced by dextran, 5-HT, carrageenin, and formalin, as well as turpentine pleurisy. Thermic edema was not influenced. The anti-inflammatory activity depended on the dose and roughly paralleled the elevation of the serum triglyceride level. FFA concentration did not seem to be an important factor in the development of the anti-inflammatory effect. Oleic acid and glycerol administered through a stomach tube had no effect on dextran inflammation, while sunflower seed oil and pig fat produced a dose-related blocking effect. Increased vascular permeability induced by dextran, compound 48/80, histamine, and 5-HT was also suppressed by Intralipid® and Triton WR 1339. Triton produced its pronounced anti-inflammatory effect only 24 h after the administration, when an extreme hypertriglyceridemia developed. Adrenalectomy did not prevent the anti-inflammatory activity. The possible significance of the findings obtained is discussed.