Anti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley Rat

Krishnaraju, Alluri V.; Rao, Chundi B.M.; Dodda, Sundararaju; Sengupta, Krishanu; Golakoti, Trimurtulu

doi:10.3844/ajidsp.2009.68.73

Cited by 18 publications

(12 citation statements)

References 19 publications

(18 reference statements)

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“…and triterpenoids produced significant antiinflammatory activities (Silva et al, 2005). The obtained anti-inflammatory results are in line with other previous studies in family Verbenaceae (Shukla et al, 2011;Amir et al, 2011;Krishnaraju et al, 2009;Monteiro et al, 2007; Penido et al, 2006; Abena et al, 2003). The anti-pyretic activity of TMEL and its fractions have been evaluated by causing reduction in yeast-induced pyrexia (Table 6).…”

Section: Resultssupporting

confidence: 87%

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Mohammed¹,

Hamed²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Chromatographic investigation of the Citharexylum quadrangulare leaves led to isolation of nine compounds viz., stigmasterol (1), β-sitosterol (2), oleanolic acid (3), duranterectoside B (4), durantoside I (5), cirsimaritin 4'-O-β-D-glucopyranoside (6), 5-deoxypulchelloside (7), lamiide (8) and cirsimaritin 4'-O-β-D-glucopyranoside 4"-sodium sulphate (9). The compounds (1, 3 and 4) were isolated for the first time from genus Citharexylum. The structures of the isolated compounds were determined by interpretation of their spectroscopical data and comparison with published literature. The aqueous fraction exhibited the most significant anti-inflammatory activity. Its effect was more potent than the reference drug. While, the most significant anti-pyretic sample was the total methanol extract. Also, it showed a gastroprotective activity with preventive index (78%). Finally, the ethyl acetate fraction demonstrated a significant decrease in blood glucose level on hyperglycemic alloxaned rats.

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Section: Resultssupporting

confidence: 87%

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Mohammed¹,

Hamed²,

Khalil³

et al. 2016

J. Med. Plants Res.

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“…After subcutaneous inject ion, CFA induces adjuvant arthritis that can serve as a model to test the anti-arthritic and anti-inflammatory effects of investigational substances. The effect observed in this model seems to be parallel to that observed in human disease (Alluri et al, 2009;Jia et al, 2003;Newbould, 1963;Pearson and Wood, 1959).…”

Section: Introductionsupporting

confidence: 79%

Anti-Arthritic Activity of the Methanolic Leaf Extract of <i>Urtica pilulifera</i> L. on Albino Rats

Abudoleh¹

2011

American Journal of Pharmacology and Toxicology

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Problem statement: Urtica pilulifera (Urticeacae) has been used in folk medicine to alleviate inflammation and arthritis. In this study the anti-arthritic effect of methanolic leaf extract of the plant was evaluated and compared to untreated control as well as ibuprofen-treated groups in a rat model of Complete Freund's Adjuvant (CFA)-induced arthritis. Approach: Arthritis was induced by injecting CFA subcutaneously into the right paw. The extract was given orally one day before CFA injection up to the completion of study (for 30 days). Two extract doses (1.33 and 2.0 g kg −1 ) and ibuprofen (53 mg kg −1 ) as a positive control were used. Paw volume was measured on alternate days up to 30 days. In addition, the effect of the extract on joint deformity, ankle swelling and inflammatory markers was evaluated. Results: The extract prevented arthritis-induced increase in paw volume and joint deformity dose-dependently as compared to control. Moreover, the extract showed significant increase in the packed cell volume [p<0.05]. No alteration of kidney or liver function tests was detected in rats during repeated dose treatment. Conclusion: This study supports the traditional use of U. pilulifera for the treatment of inflammatory disorders and rheumatoid arthritis and suggests further evaluation for its role in increasing red blood cells.

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“…Accumulating lines of evidence show that oxidative stress mechanism has been implicated in the pathogenesis of psychiatric and brain disorders (Krishnaraju et al, 2009). Recently, numerous studies demonstrated that substance possessing antioxidant activity could reduce psychiatric symptoms and improve cognitive function (Jittiwat et al, 2009;Hasan et al, 2009;Phachonpai et al, 2010;Tong-Un et al, 2010a;2010b;2010c).…”

Section: Introductionmentioning

confidence: 99%

Screening Neuropharmacological Activities of <i>Kaempferia parviflora</i> (Krachai Dam) in Healthy Adult Male Rats

Hawiset¹

2011

American Journal of Applied Sciences

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Problem statement:Although the global prevalence of psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substance possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Kaempferia parviflora, a medicinal plant claimed for nerve tonic, also possessed the neuropharmacological activities which provide the advantage for psychiatric disorders. Approach: Adult male Wistar rats, weighing 180-220 grams, were orally given the ethanolic extract of K. parviflora at doses of 150, 200 and 250 mg kg −1 BW once daily for 2 weeks. Then, they were determined the neuropharmacological activities including anxiolytic, anti-depression like behavior and cognitive enhancement after single dose, 1 and 2 weeks of treatment. Results: K. parviflora possessed anti-depression like behavior and cognitive enhancement at all treatment duration. Unfortunately, this substance failed to show anxiolytic like activity. Conclusion: Our results suggested that K. parviflora might be used as a novel therapeutic strategy for psychiatric disorder and cognitive enhancement. However, further investigations about precise underlying mechanism are still required.

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Anti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley Rat

Cited by 18 publications

References 19 publications

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Anti-Arthritic Activity of the Methanolic Leaf Extract of <i>Urtica pilulifera</i> L. on Albino Rats

Screening Neuropharmacological Activities of <i>Kaempferia parviflora</i> (Krachai Dam) in Healthy Adult Male Rats

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