Anti-Inflammatory Agents

Intravitreal concentrations of some drugs administered with microdialysis

“…Probably it can be regarded as well within the therapeutic range concerning the receptor binding results mentioned above (Polansky & Weinreb 1984).…”

“…Tissue concentrations in the 40-500 nM range have been shown to give the maximal receptor binding (Polansky & Weinreb 1984). The anti-inflammatory effects are considered to be mediated through glucocorticoid receptors and the subsequent regulation of specific protein synthesis (Polansky & Weinreb 1984).…”

Posttraumatic Intraocular Pressure Elevation and Associated Factors in Patients with Zone I Open Globe Injuries

“…The rise in IOP tends to occur two to three weeks after initiation of therapy and is dose-dependent. [14] Even after cessation of corticosteroid treatment, sometimes patients require lifelong IOP control, perhaps owing to irreversible changes in the trabecular meshwork. [15] Initial IOP is usually low after open globe injury, but after wound closure, IOP elevation and subsequent glaucoma may develop.…”

Migration of retinal pigment epithelial cells in vitro modulated by monocyte chemotactic protein-1: enhancement and inhibition

“…Dexamethasone (DEX) has numerous anti-inflammatory effects, including suppression of cytokine-mediated responses [41], and daunorubicin demonstrates a strong ability to inhibit the proliferation of fibroblasts [50]; both have been used in treatment of experimental PVR [25]. The effects of MCP-1 combined with DEX or daunorubicin were also tested.…”