Anti‐inflammatory Agents from Medicinal Plants

Tùng, Bùi Thanh; Linh, Tran V.; Thao, Trinh P.; Thuan, Nguyen Duy

doi:10.1002/9781119794127.ch9

Phytochemical Drug Discovery for Central Nervous System Disorders 2023

DOI: 10.1002/9781119794127.ch9

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Anti‐inflammatory Agents from Medicinal Plants

Bùi Thanh Tùng

Tran V. Linh

Trinh P. Thao

et al.

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2024

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Cited by 2 publications

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Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights

Furtado,

Ross,

de Almeida Junior

et al. 2023

Fundamemntal Clinical Pharma

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BackgroundKaurenol, a diterpene alcohol found in Copaifera langsdorffii Desf. (known as “copaiba”), is historically used in traditional medicine for inflammatory conditions.ObjectivesThis study aims to comprehensively assess the potential anti‐inflammatory and antinociceptive properties of kaurenol.MethodsTo this end, the following experiments were conducted to evaluated toxicity: locomotor performance and acute toxicity; nociception: acetic acid‐induced writhing and formalin‐induced antinociception; and anti‐inflammatory activity: carrageenan and dextran‐induced paw edema at 10, 20, and 40 mg/kg, and measurement of nitric oxide (NO), tumor necrosis factor alpha (TNF‐α), interleukin‐6 (IL‐6), and interleukin‐10 (IL‐10) in macrophages at 1, 3, and 9 μg/ml.ResultsKaurenol did not show significant locomotor changes, acute toxicity, and central analgesic activity in the first phase of formalin test at dosages tested. Kaurenol showed 53%, 64%, 64%, and 58% of inhibition in the acetic acid‐induced writhing, second phase of formalin test, carrageenan and dextran‐induced paw edema, respectively.ConclusionThe anti‐inflammatory activity was associated with the regulation of NO release and probably with the regulation of mediators, such as serotonin and prostaglandin in vascular permeability, as well as by being associated with the regulation of IL‐6 and IL‐10. Kaurenol display anti‐inflammatory activity but has no analgesic activity.

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Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights

Furtado,

Ross,

de Almeida Junior

et al. 2023

Fundamemntal Clinical Pharma

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Exploring Synergistic Inhibition of Inflammatory and Antioxidant Potential: Integrated In Silico and In Vitro Analyses of Garcinia mangostana, Curcuma comosa, and Acanthus ebracteatus

Eawsakul,

Bunluepuech

2024

Advances in Pharmacological and Pharmaceutical Sciences

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Compared with the use of a single herb alone, herb combinations can significantly increase their effectiveness in treating various diseases. The objective of this research was to determine the appropriate proportions of Garcinia mangostana (GM), Curcuma comosa (CC), and Acanthus ebracteatus (AE) to enhance their antioxidant and anti‐inflammatory properties. The study employed computer modeling (in silico) and laboratory testing (in vitro). The optimal levels of phenolic and flavonoid compounds were achieved with a ratio of 15 parts GM, 5 parts CC, and 10 parts AE. In contrast, the 10 : 15 : 5 ratio resulted in the highest antioxidant activity, reducing DPPH radicals by 80.33% and ABTS radicals by 92.20%. The ratio had a synergistic effect and was within the safe range, ranging from 82.97 to 147.04 µg/mL. The ratio of 5 : 10 : 15 had the greatest anti‐inflammatory effects, with an exceptional activity level of 98.86%. It effectively suppressed 23 genes or proteins, including the prominent NFE2L2 gene, and had a synergistic effect. This combination effectively inhibits inflammation (IC50: 12.05 µg/mL) and is safe for macrophages at concentrations up to 50 µg/mL. These findings emphasize the potential of these herbal mixtures for antioxidant and anti‐inflammatory applications.

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Anti‐inflammatory Agents from Medicinal Plants

Cited by 2 publications

References 139 publications

Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights

Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights

Exploring Synergistic Inhibition of Inflammatory and Antioxidant Potential: Integrated In Silico and In Vitro Analyses of Garcinia mangostana, Curcuma comosa, and Acanthus ebracteatus

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