Anti-inflammatory Agents III: Structure–Activity Relationships of Brusatol and Related Quassinoids

Hall, Iris H.; Lee, K.H.; Imakura, Yasuhiro; Okano, Masayoshi; Johnson, Austin

doi:10.1002/jps.2600721111

Cited by 58 publications

(40 citation statements)

References 21 publications

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“…Further studies are required to elucidate the mechanism by which bruceine A displays its potent antibabesial activity for the further development of novel combination chemotherapies with different antibabesial compounds. Quassinoid compounds have anti-inflammatory activities in vitro and in vivo [8,14,28]. Hall et al [8] reported that brusatol, another analogous quassinoid to bruceine A, reduced inflammation and arthritis in rodents.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Efficacy of Bruceine A, a Natural Quassinoid Compound Extracted from a Medicinal Plant, Bruced javanica, for Canine Babesiosis

et al. 2009

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ABSTRACT. Bruceine A, a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) Merr., was evaluated for its antibabesial activity in vitro and in vivo. Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection. An untreated dog developed typical acute babesiosis symptoms including severe anemia, high fever, and complete loss of appetite and movement. However, the two bruceine A-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks although complete elimination of parasites from the peripheral blood was not achieved and decreases in the packed cell volume and the erythrocyte and platelet counts were observed. Since natural quassinoid compounds have been used as traditional medicines for the treatment of various ailments including cancer and malaria, the present results suggest that bruceine A or other related compounds are potential candidates for the treatment of canine babesiosis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Efficacy of Bruceine A, a Natural Quassinoid Compound Extracted from a Medicinal Plant, Bruced javanica, for Canine Babesiosis

et al. 2009

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“…In the last few years, the therapeutic purposes have increased because of its antimalarial, antiinflammatory, antileukemic, antifeedant, and antiviral activities (Engler and Prantl 1872). In Brazil, the Simaroubaceae family is represented by the genera Quassia and Picrolemma, in the Amazonian Region, Castela and Picrasma, in the south of the country, and Simaba, Simarouba and Picrolemma which are present throughout Brazil (Hall et al 1983). …”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of Simarouba versicolor

Arriaga

Mesquita

Pouliquen

et al. 2002

An. Acad. Bras. Ciênc.

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“…No Brasil, está representada pelos gêneros Quassia e Picrolemma, na região Amazônica; Castela e Picrasma, no sul do país; Simaba e Simarouba em quase todas as regiões brasileiras 6 . As Simaroubaceae geralmente se apresentam como árvores ou arbustos, tendo como característica marcante um sabor bastante amargo em seu córtex.…”

Section: Ocorrência Dos Quassinóidesunclassified