Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations

Matalka, Khalid Z.; Alfarhoud, Fatema; Qinna, Nidal A.; Mallah, Eyad; Dayyih, Wael Abu; Muhi-Eldeen, Zuhair

doi:10.1016/j.intimp.2012.07.016

Cited by 8 publications

(8 citation statements)

References 30 publications

(48 reference statements)

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“…Conversely, ZM5 showed less pronounced activity in the late formalin phase ( P > 0.05) which again reflects the superiority of ZM4 in reducing acute and chronic pain. Nevertheless, such conclusion should not reflect the less anti-inflammatory ability of ZM5 as we have recently reported that ZM5 showed comparable anti-inflammatory effects to diclofenac and celecoxib in rat paw edema test and enhances the production of transforming growth factor- β from T regulatory cells as compared with other tested compounds [11, 13, 14]. Therefore, it could be suggested that ZM5 has slow rate of absorption through gastrointestinal tract since it neither showed any anti-inflammatory effect during the first hour after carrageenan paw edema induction nor any significant reduction in the late phase of formalin test.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, these compounds were shown to exhibit effect on enhancing anti-inflammatory and reducing proinflammatory cytokines from different population of spleen cells [14]. Such effects strengthen the use of such compounds, but more pharmacokinetic and pharmacodynamic studies are warranted.…”

Section: Discussionmentioning

confidence: 99%

“…This unique combination represents a new series of compounds as potential anti-inflammatory agents as has been shown to reduce carrageenan-induced paw edema and structurally differs from the generally used drugs that contain acidic, enolic, sulfonamide, or sulfon groups which should exclude the direct insult on the gastrointestinal [11]. Of all the molecules reported in our previous studies, ZM4 and ZM5 were found to possess the best COX-2 inhibition activities, better in reducing carrageenan-inducing inflammation, and modulate proinflammatory and anti-inflammatory cytokines [11, 13, 14] and therefore were selected for further efficacy and safety investigations. The aim of the present study therefore is to study the analgesic activity of these compounds in addition to studying their toxicity and ulcerogenic effect on the stomach following single and repeated administration.…”

Section: Introductionmentioning

confidence: 99%

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Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

et al. 2012

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We have developed a series of aminoacetylenic isoindoline-1,3-dione compounds and showed their anti-inflammatory activities by reducing carrageenan-induced rat paw edema and modulating proinflammatory and anti-inflammatory cytokines. In the present study and due to efficacy reasons, we are exploring only two of these compounds, namely, ZM4 and ZM5, to reveal their analgesic activity and toxicity. Following oral administration, both compounds were effective in reducing significantly (P < 0.05–0.001) acetic acid-induced writhing behavior, hot plate latency test, and formalin-induced paw licking time as antinociceptive indicators in mice and rats, respectively. Regarding the toxicity, the acute (20, 50, and 150 mg/kg) and repeated oral administration (10, 20, and 50 mg/kg) of these compounds for ten days did not produce any mortality and the compounds were considered well tolerated. However, repeated oral administration of 50 mg/kg of both compounds induced erythropoiesis by means of increasing significantly red blood cells, hemoglobin, and packed cell volume. Moreover, these compounds did not induce gastric lesions in the stomach of experimental animals at the doses that exhibited analgesic and anti-inflammatory activity compared to indomethacin as a positive control. The results indicate that ZM4 and ZM5 possess potential analgesic activity while being preliminarily safe and have minimal ulcerogenic activity.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

et al. 2012

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“…During the activity, spleen involves the development of an immunological milieu induced by dietary Cu consumption. Three steps may be involved in the immunological activities: Step 1, spleen secrete inflammatory cytokines (Matalka et al., ), including IL‐1 and TNF (Fig. ); Step 2, antigen‐presenting cell activates donor‐derived T cells, which induce T‐cell expansion, resulting in response to cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.…”

Section: Discussionmentioning

confidence: 99%

Dietary copper affects antioxidant and immune activity in hybrid tilapia (Oreochromis niloticus × Oreochromis aureus)

et al. 2017

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Copper (Cu) is an essential nutrition trace element for Tilapia. However, the molecular mechanisms for the effects of Cu on Tilapia remain unknown. To explore the mechanism, 2,160 hybrid tilapia (Oreochromis niloticus × Oreochromis aureus) fries were used and evenly assigned to six groups and fed with different concentrations of Cu. After 60-day culture, physiological characters and biochemical parameters were measured. Spleen somatic index (SSI) was analysed, and distribution of trace elements was investigated. qRT-PCR was used to analyse the levels of immune genes. The result showed that 17 mg kg −1 of dietary Cu improved the growth rate, survival rate (SR), weight gain rate, condition factor and feed conversion ratio of hybrid tilapia (p < .05). Meanwhile, the dietary Cu increased the activity of superoxide dismutase and reduced the activity of glutathione (GSH), alanine aminotransferase, aspartate aminotransferase and lysozyme (p < .05). Sixteen mg kg −1 of dietary Cu did not affect SSI. Furthermore, dietary Cu affects the levels of immune genes, interleukin-1, tumour necrosis factor, MHC class IIB, pre-B-cell leukaemia transcription factor 1 and P450. Therefore, a certain concentration of Cu can improve tilapia performance by affecting its antioxidant and immune activity.

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“…Isoindole derivatives exhibiting antifungal , antimalarial , anticonvulsant , anti‐asthamatic , antiplasmodial , and antimicrobial and pyrrolopyrazine derivatives exhibiting anti‐arrhythmic activity are reported in literature. Isoindole and pyrrolopyrazine derivatives possessing anti‐inflammatory , anticancer , and antibacterial activities are well‐documented in literature. These compounds are also reported to act as HIV‐1 integrase inhibitors .…”

Section: Introductionmentioning

confidence: 99%

Grinding and Microwave‐assisted Synthesis of Heterocyclic Molecules in High Yields and Their Biological Evaluation

Kumar

Nikhil

et al. 2015

Journal of Heterocyclic Chem

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Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations

Cited by 8 publications

References 30 publications

Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

Dietary copper affects antioxidant and immune activity in hybrid tilapia (Oreochromis niloticus × Oreochromis aureus)

Grinding and Microwave‐assisted Synthesis of Heterocyclic Molecules in High Yields and Their Biological Evaluation

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