2000
DOI: 10.1016/s0378-8741(00)00205-1
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Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca)

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Cited by 279 publications
(179 citation statements)
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“…Thus, the dose 200 mg/kg was ineffective as antiedematogenic. According to the results obtained from the infl ammation models used in the present study, S. cordifolia seems not to interfere with the lipooxygenase pathway but rather with the cyclooxygenase pathway (prostaglandin biosynthesis) (Franzotti et al, 2000).…”
Section: Anti-infl Ammatory Activity Of Crude Plant Extractssupporting
confidence: 58%
See 1 more Smart Citation
“…Thus, the dose 200 mg/kg was ineffective as antiedematogenic. According to the results obtained from the infl ammation models used in the present study, S. cordifolia seems not to interfere with the lipooxygenase pathway but rather with the cyclooxygenase pathway (prostaglandin biosynthesis) (Franzotti et al, 2000).…”
Section: Anti-infl Ammatory Activity Of Crude Plant Extractssupporting
confidence: 58%
“…Therefore, that study results, provide a preliminary scientifi c foundation for the use of P. pubescens infusions in popular medicine for the treatment of rheumatoid arthritis. Franzotti et al (2000) studied Sida cordifolia L. (Malvaceae) which is popularly known in Brazil as "malva-branca" or "malva-branca-sedosa". The aqueous extract (AE) of S. cordifolia leaves was studied to assess the anti-infl ammatory properties using the carrageenin and arachidonic acid induced rat paw edema model.…”
Section: Anti-infl Ammatory Activity Of Crude Plant Extractsmentioning
confidence: 99%
“…The abdominal injection of acetic acid in mice has been attributed to the release of arachidonic acid via the cyclooxygenase enzyme. Also, it has been suggested that the inhibition of prostaglandin synthesis by this pathway is remarkably efficient as an anti-nociceptive mechanism in visceral pain (Franzotti et al 2002). Since all tested doses of Z. montana leaf extract were able to inhibit the acetic acid-induced writhes, the peripheral analgesic activity exhibited by this extract may be related to the inhibition of prostaglandin production.…”
Section: Resultsmentioning
confidence: 91%
“…Franzotte et al, (2000) reported low acute toxicity of AESC leaves in mice [21]. Rao and Mishra reported that the lethal dose 50% (LD 50 ) value for S. cordifolia was higher than 10 g/kg in rats [22].…”
Section: Discussionmentioning
confidence: 99%