Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. &amp; Zucc. (Malvaceae) bark

Rosa, Roseane Leandra da; Nardi, Geisson Marcos; Januário, Adriana Graziele de Farias; Boçois, Renata; Bagatini, Katiane Paula; Bonatto, Sandro José Ribeiro; Pinto, Andrea de Oliveira; Ferreira, João Ronaldo Notargiacomo; Mariano, Luísa Nathália Bolda; Niero, Rivaldo; Iagher, Fabíola

doi:10.1590/s1984-82502014000300020

Cited by 17 publications

(12 citation statements)

References 49 publications

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“…This held the dose-dependent response and the proportional increase rate observed previously in phagocytosis activity. Lysosomes play the role of digesting intracellular components and also break down phagocytosed material, through the fusion of phagosome to hydrolase-containing lysosomal vesicles 68 , improving the defense cell mechanism.…”

Section: Chlorophyll Quantification Leaves Ofmentioning

confidence: 99%

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Gollo

Tanobe

Pereira

et al. 2020

Sci Rep

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In this study, Response surface methodology (RSM) was applied to optimize the yield of crude methanolic extract of Mitragyna speciosa leaves using Ultrasound-assisted extraction (UAE). The crude methanolic extract and its fractions were quanti ed in terms of total phenolic content and total avonoid content, along with characterized using Fourier-transform infrared and Gas chromatography-mass spectrometry. The results showed the maximum yield of 49.72% at the optimal conditions (temperature, 34 °C; time, 25 min; and volume of solvent, 166 mL). The recovery crude methanolic extract for TPC and TFC were 137.3 ± 15.7 mg GAE/g and 90.3 ± 15.3 mg RE/g, respectively.

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Section: Chlorophyll Quantification Leaves Ofmentioning

confidence: 99%

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Gollo

Tanobe

Pereira

et al. 2020

Sci Rep

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“…[ 14 ] Inflammatory processes is an important hallmark of diseases or pathological conditions described above and many plants have demonstrated anti-inflammatory effects by modulating oxidative stress. [ 15 16 ]…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

et al. 2016

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Background:Many fruits have been used as nutraceuticals because the presence of bioactive molecules that play biological activities.Objective:The present study was designed to compare the anti-inflammatory and antioxidant effects of methanolic extracts of Lycium barbarum (GOJI), Vaccinium macrocarpon (CRAN) and Vaccinium myrtillus (BLUE).Materials and Methods:Mices were treated with extracts (50 and 200 mg/kg, p.o.), twice a day through 10 days. Phytochemical analysis was performed by high-performance liquid chromatography. Antioxidant activity was determine by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, reducing power, lipid peroxidation thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and catalase (CAT) activity. Anti-inflammatory activity was evaluated by paw edema followed by determination of myeloperoxidase (MPO) and TBARS.Results:High amount of phenolic compounds, including rutin, were identified in all berries extracts. However, quercetin was observed only in BLUE and CRAN. GOJI presents higher scavenging activity of DPPH radical and reducing power than BLUE and CRAN. The extracts improved antioxidant status in liver; BLUE showed the largest reduction (75.3%) in TBARS when compared to CRAN (70.7%) and GOJI (65.3%). Nonetheless, CAT activity was lower in BLUE group. However, hepatic concentrations of GSH were higher in animals treated with GOJI rather than CRAN and BLUE. Despite all fruits caused a remarkable reduction in paw edema and TBARS, only BLUE and CRAN were able to reduce MPO.Conclusion:These results suggest that quercetin, rutin, or other phenolic compound found in these berry fruits extracts could produce an anti-inflammatory response based on modulation of oxidative stress in paw edema model.SUMMARY Within fruits broadly consumed because of its nutraceuticals properties include, Lycium barbarum (Goji berry), Vaccinium myrtillus (Blueberry or Bilberry) and Vaccinium macrocarpon (Cranberry)The objectives of this study were the investigation and comparison of chemical composition, antioxidant activity “in vitro” and “in vivo” and anti inflammatory property of berry fruits bought dry form.In summary, two main findings can be addressed with this study: (1) Berry fruits presented antioxidant and anti inflammatory activities “in vitro” and “in vivo”; (2) the extracts of GOJI, CRAN, and BLUE modulate the inflammatory process by different mechanisms.

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“…A atividade antinociceptiva desse extrato é comprovada pela redução do numero de contorções na posologia de 160 mg/Kg, que foi mais efetiva que a indometacina. Rosa et al (2014), avaliando a atividade antinociceptiva do extrato bruto de L. divaricata, observou que esse extrato foi eficaz na redução do comportamento de contorção abdominal na dose de 30 mg/Kg. Portanto, pode-se inferir que os compostos químicos do EEtOH-Ld contribuam para o alívio de dores leves a moderadas.…”

Section: Methodsunclassified

“…Esse resultado sugere que o EEtOH-Ld possui atividade antiinflamatória semelhante à indometacina, capaz de reduzir o edema de pata induzido por carragenina. Rosa et al (2014), avaliando as propriedades anti-inflamatórias do extrato bruto de L. divaricata, observou uma redução dose-dependente do volume do edema da pata em ratos induzido por carragenina. Este efeito foi evidente 30 minutos após a administração oral do extrato bruto de L. divaricata, e mantido durante todo o período de avaliação (Rosa et al, 2014).…”

Section: Tempo De Lambida De Pata (S)unclassified

Atividades antinociceptiva e antiinflamatória do extrato etanólico de Luehea divaricata

Batista

Trindade

Lira

et al. 2016

Rev. bras. plantas med.

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Recebido para publicação em 15/07/2015 Aceito para publicação em 12/04/2016 RESUMO: Considerando os diferentes usos etnofarmacológicos apresentados pela planta Luehea divaricata, realizou-se este estudo com o objetivo de avaliar as atividades antinociceptiva e antinflamatória do extrato etanólico de suas folhas, em modelo animal, nas dosagens de 20, 40, 80 e 160 mg/Kg, por via oral. Foram realizados os seguintes testes: contorções abdominais induzidas pelo acido acético, placa quente, formalina e edema de pata induzido por carragenina. Foram utilizados camundongos Swiss (20-25 g) para os três primeiros testes e ratos Wistar (180-250 g), para o último, divididos em seis grupos de oito animais, totalizando 48 animais em cada parâmetro de avaliação. Os resultados foram analisados estatisticamente pela análise de variância a 5% de probabilidade, para verificar quais os tratamentos que diferiram entre si, e estes foram submetidos aos testes de Kruskall-Wallis e Student-Newman-Keuls. O extrato etanólico das folhas de L. divaricata (EEtOH-Ld), nas diferentes doses estudadas, apresentou significativa atividade antinociceptiva sobre a dor induzida quimicamente por injeções intraperitoneal de acido acético e intraplantar de formalina. Na dosagem de 160 mg/Kg, esse extrato apresentou ação analgésica central, aos 120 minutos de observação, no teste de placa quente e reduziu o edema de pata induzido pela administração de carragenina, uma hora após a administração do agente inflamatório, semelhante ao efeito produzido pelo fármaco padrão. Palavras-chave: açoita-cavalo, dor, plantas medicinais.ABSTRACT: Antinociceptive and anti-inflammatory activities of Luehea divaricate ethanol extract. Considering the different ethnopharmacological uses submitted by the plant Luehea divaricata, this study took place in order to evaluate the antinociceptive and anti-inflammatory activities of the ethanol extract of the leaves in an animal model, the dosages of 20, 40, 80 and 160 mg/kg by oral intake. The following tests were performed: writhing induced by acetic acid, hot plate, formalin, and paw edema induced by carrageenan. Swiss mice (20-25 g) were used for the first three tests and Wistar rats (180-250 g) for the last, divided into six groups, each of eight animals, totaling 48 animals for each assessment parameter. The results were statistically analyzed by analysis of variance at 5% probability to verify which treatments differ, and these were tested by Kruskal-Wallis and Student-Newman-Keuls. The ethanol extract of L. divaricataleaves (EEtOH-Ld) at the different studied doses showed significant antinociceptive activity on chemically induced pain by intraperitoneal injections of acetic acid and intraplantar formalin. At a dosage of 160 mg/kg, this extract showed a central analgesic action after 120 minutes of observation in the hot plate test and reduced action in the paw edema induced by carrageenan one hour after the administration of the inflammatory agent, similar to the effect produced by the standard drug.

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Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark

Cited by 17 publications

References 49 publications

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation

Atividades antinociceptiva e antiinflamatória do extrato etanólico de Luehea divaricata

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