Anti-Inflammatory, Analgesic and Ulcerogenic Activity of Vigna Mungo Linn. Leaves

Abstract

<p>The anti-inflammatory, analgesic and ulcerogenic activity of extract of leaves of <em>Vigna Mungo </em>linn. (Leguminosae) were investigated as well as the mechanisms of action. The extract significantly (P<0.05) inhibited the formation of paw edema induced by    carrageenan in rat and increased reaction latency to thermal pain in rat in a dose-dependent manner. The extract caused a significant (P<0.05) dose-dependent ulceration of rat gastric mucosa and concentration-dependent inhibition of hypotonicity-induced haemolysis of red blood cell. Also the extract significantly (P<0.05) inhibited the activates of the phospholipase A₂ and prostaglandine synthesis in a concentration related manner. These suggest that the leaves posses anti-inflammatory, analgesic and ulcerogenic activities mediated through sequential inhibition of the enzymes responsible for prostaglandine synthesis from arachidonic acid. Phytochemical analysis of the extract revealed the presence of glycoside, tannins, alkaloid, flavonoids and Saponins. Acute toxicity studies established an oral LD₅₀greater than 3000 mg/kg.</p

Evaluation of anti-osteoarthritic activity of Vigna mungo in papain induced osteoarthritis model

“…Taken together, this improvement in pain behavior could be resulted from the inhibition of prostaglandins by flavonoids present in VMHA and/or may be through central pathways of analgesia. [ 10 ]…”

“…In addition to these VM has been reported pharmacologically to possess anti-inflammatory activity, analgesic activity,[ 10 ] anti-cancer activity[ 11 ] and hepatoprotective activity. [ 9 ] It has also been described for its MMP inhibiting activity.…”

Medicinal Properties of Māsh (Vigna mungo (Linn.) Hepper): A Comprehensive Review

“…Black gram is grown mainly in Central and Southeast Asia. It is widely distributed in tropical West Africa and extensively cultivated all over India 5,7,14,16,18,25 . The Guntur District ranks first in Andhra Pradesh for the production of black gram in India 3 .…”

“…When used externally it acts as Taḥlīl-i-Awrām (dissolvent), Jālī (corrosive), Musakkin-i-Alam (analgesic) 21 and Mulayyin (laxative) 30 . The plant leaves may possess anti-inflammatory, analgesic, and ulcerogenic properties among others 16 . In traditional medicine, the seed is used for its suppurative, cooling, and astringent properties 25…”

“…Used in rheumatism, paralysis, aching bones, affections of the nervous system, and diseases of the liver 1,2,5,11,14,16,32 . It is medicinally used both internally and externally, internally used in the form of decoction in dyspepsia, strangury, constipation, hepatopathy, neuropathy, and agalactia.…”