Anti-Inflammatory and Analgesic Activities of SKLJI, a Highly Purified and Injectable Herbal Extract of <i>Lonicera japonica</i>

Ryu, Keun Ho; Rhee, Hae In; Kim, Joo Hyon; Yoo, Han‐Ill; Lee, Bong Yong; Um, Key-An; Kim, Keunyoung; Noh, Jinhyun; Lim, Kyung Min; Chung, Jin

doi:10.1271/bbb.100279

Cited by 45 publications

(33 citation statements)

References 30 publications

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“…To date Mastixia have been reported only for loganin and loganic acid. 10,18) The iridoid compound especially loganin inhibited COX-2 enzyme activities, TNF-, and NO production in vivo 19) and in vitro. 20) Firstly we identified a biological effect of methanol extract of MA, and it is possible if extract inhibits inflammatory disease due to constituents including loganin.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activities of Methanol Extract ofMastixia arboreaC.B. Clarke as to Mouse Macrophage and Paw Edema

Kim

Kwon

Park

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activities of Methanol Extract ofMastixia arboreaC.B. Clarke as to Mouse Macrophage and Paw Edema

Kim

Kwon

Park

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…Honeysuckles are used in herbal medicines, and they possess biological and pharmaceutical properties such as anti-bacterial, anti-inflammatory, anti-viral, liver protectant, anti-angiogenic, and anti-nociceptive activities (Ku et al, 2009;Rahman and Kang, 2009;Ryu et al, 2010;Kang et al, 2010). Five species of honeysuckle, namely, Lonicera (L.) japonica, L.…”

Section: Introductionmentioning

confidence: 99%

Molecular authentication of multi-species honeysuckle tablets

Jiang

Yao²,

Chen³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Authenticating multi-species original raw materials in commercial formulations is difficult. Jin Yin Hua and Shan Yin Hua, both classified as raw honeysuckle materials in the Chinese Pharmacopoeia, are used in various medicines. Differentiating one variety from another is difficult based on chemical analysis. We developed molecular authentication of multi-species original honeysuckle in 3 brands of commercial tablets using allele-specific PCR. All 3 tablets contained both Jin Yin Hua and Shan Yin Hua. We also built a PCR-enzyme digestion method and enzymatic mutation detection in the PCR fragments of psbAtrnH and trnL-trnF, and the restriction endonucleases HinfI and NlaIV, respectively. The PCR-enzyme digestion method produced the same result as the allele-specific PCR. Sequence and phylogenetic analyses show that the tablets YXC and YQJ contained Lonicera japonica and L. macranthoides as original raw materials, and LYG contained L. japonica, L. hypoglauca, and L. macranthoides.

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“…Additionally, the whole plant of L. japonica, which is widely distributed widely in China and Korea, has frequently been used as an anti-infl ammatory agent, especially for the treatment of respiratory tract infl ammation (Lee et al, 1998). Recently, it was also reported that highly purifi ed fraction showed potent antiinfl ammatory and analgesic activities (Ryu et al, 2010). It has previously been reported that a 1:1 (w/w) mixture (BL) of the ethylacetate fraction from the root barks of B. papyrifera and the 70% aqueous ethanol extract from the whole plants of L. japonica exerted signifi cant and considerable anti-infl ammatory activity in vitro and in vivo (Jin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Experimental Lung Inflammation and Bronchitis by Phytoformula Containing Broussonetia papyrifera and Lonicera japonica

Ko¹,

Jin²,

Kwon³

et al. 2011

Biomolecules and Therapeutics

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Many patients suffer from lung infl ammatory disorders including asthma, bronchitis and chronic obstructive pulmonary disorders (COPD). Several classes of drugs including bronchodilators, antitussives, steroids and leukotriene (LT) receptor antagonists have been used to treat these disorders. However, these drugs sometimes do not provide fundamental care, even though the major symptoms are alleviated (Jeffery, 2001). Thus, new effective drugs with novel action mechanism(s) are needed to treat lung infl ammatory disorders. In this regard, natural products may be applied safely for treating human lung infl ammation and bronchitis.The root barks of Broussonetia papyrifera (L.) Vent. (Moraceae) distributed in China, Japan and Korea have been used as anti-infl ammatory and antitussive agents in traditional Chinese medicine, especially for the treatment of older people having bronchitis (Editorial Committee, 1999). Recently, the 95% ethanol extracts of the radix, stems, leaves and fruits of B. papyrifera showed antinociceptive and anti-infl ammatory activity in vivo, with radix having the strongest activity (Lin et al., 2008). Lonicera japonica (Thunb.) (Caprifoliaceae) is a Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of infl ammatory disorders, especially respiratory infl ammation, in Chinese medicine. Previously, phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-infl ammatory activity in vitro and in vivo. In this study, the effects of BL on lung infl ammation including bronchitis were examined in vitro and in vivo. BL (10-100 μg/ml) inhibited nitric oxide (NO) production of lipopolysaccharide (LPS)-treated alveolar macrophages, MH-S cells, primarily by down-regulating inducible NO synthase. BL also inhibited production of the proinfl ammatory cytokines, TNF-α and IL-6. Against an animal model of pleural cavity infl ammation, BL (200-400 mg/kg) signifi cantly inhibited 5 h and 24 h carrageenan-induced pleurisy in rats when administered orally. Additionally, BL inhibited experimental bronchitis induced by intratracheal instillation of LPS to rats. Taken together, these results indicate that BL may be effective for the treatment of human lung infl ammation as well as bronchitis.

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Anti-Inflammatory and Analgesic Activities of SKLJI, a Highly Purified and Injectable Herbal Extract of Lonicera japonica

Cited by 45 publications

References 30 publications

Anti-Inflammatory Activities of Methanol Extract ofMastixia arboreaC.B. Clarke as to Mouse Macrophage and Paw Edema

Anti-Inflammatory Activities of Methanol Extract ofMastixia arboreaC.B. Clarke as to Mouse Macrophage and Paw Edema

Molecular authentication of multi-species honeysuckle tablets

Inhibition of Experimental Lung Inflammation and Bronchitis by Phytoformula Containing Broussonetia papyrifera and Lonicera japonica

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