Throughout the environment, including in food, water, soil, and the air, arsenic is a naturally occurring metalloid. An important global problem is the human exposure to arsenic from numerous sources, such as polluted groundwater and other human activities. It poses a serious danger to people's health, economic security, and social standing, particularly in the world's least developed nations, as its exposure to humans has been related to a wide range of illnesses. Diabetes, hyperkeratosis, cancer, hypertension, and neurodegeneration are a few of the serious illnesses that have been connected to arsenic exposure. There is currently no known or authorised treatment for arsenic poisoning. We made an effort to shed light on some of the most important scientific facts on arsenic toxicity that have been published in the literature. It is important for policymakers to develop regulations for a cleaner environment and raise public knowledge of arsenic toxicity.