Anti-inflammatory and analgesic activity in the polyherbal formulation Maharasnadhi Quathar

Thabrew, M.I.; Dharmasiri, M.G.; Senaratne, L

doi:10.1016/s0378-8741(03)00016-3

Cited by 43 publications

(25 citation statements)

References 13 publications

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“…Rosmarinic and carnosic acids accumulate in Boraginaceae and Lamiaceae plants and may have therapeutic potential in RA [30,31]. Eugenol is present in Laurus nobilis [32] and most notably in Syzygium aromaticum [33] that is part of a polyherbal formulation bmaharasnadhi quatharQ used for its significant anti-inflammatory and analgesic activities in RA [34].…”

Section: Discussionmentioning

confidence: 99%

Plant-derived anti-inflammatory compounds affect MIF tautomerase activity

Molnár

Garai

2005

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Plant-derived anti-inflammatory compounds affect MIF tautomerase activity

Molnár

Garai

2005

International Immunopharmacology

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“…On the other hand, the ALE had failed to inhibit heat-induced hemolysis of rat erythrocytes in vitro (Ratnasooriya et al, 2004). This indicates that ALE cannot stabilize lysosomal membranes to inhibit the release of proteolytic enzymes: lysosomes play a major role in the inflammatory reaction (Hess & Millonig, 1972;Thabrew et al 2003), and there is a close similarity between erythrocyte and lysosomal membrane system (Hess & Millonig, 1972).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Activity of the Aqueous Leaf Extract ofIxora coccinea.

Ratnasooriya

Deraniyagala

Galhena

et al. 2005

Pharmaceutical Biology

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The aim of this study was to investigate the antiinflammatory potential of an aqueous leaf extract (ALE) of Ixora coccinea (Rubiaceae) in rats after oral administration (500, 1000 and 1500 mg=kg). This was done using the carrageenan-induced paw edema (acute inflammatory model) and cotton pellet granuloma tests (chronic inflammatory model). In the former test, ALE significantly impaired both early and late phases of the inflammatory response and also the edema maintained between the two phases. In the latter test, it significantly suppressed granuloma formation (only highest dose tested). Collectively, these data show promising anti-inflammatory activity against both acute and chronic inflammation. ALE showed strong antihistamine and antioxidant activities that can account for its anti-inflammatory potential. In addition, inhibition of prostaglandins and bradykinins may play a role.

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“…Some of these compounds have already shown beneficial effects in adjuvant or carageenen-induced arthritis in animals [83,84]. Moreover, most of these compounds are used as complimentary remedies in the treatment of inflammatory conditions including human arthritis [85,86].…”

Section: Plant-derived Mif Inhibitorsmentioning

confidence: 99%