Anti-inflammatory and analgesic activity of the methanol extract of Malva parviflora Linn (Malvaceae) in rats

Abstract

Malva parviflora Linn Malvaceae is a medicinal plant used for the treatment of wounds and other related ailments by the Xhosa people of South Africa. The anti-inflammatory activity of the stem extract of this plant was assessed using carrageenan-induced paw oedema and histamine-induced paw oedema. The analgesic effect was determined using the acetic acid writhing method as well as formalin test. The extract at 100 and 200 mgkg -1 body weight reduced significantly, the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by reduction in the number of writhes when compared to the control. The extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin, signifying its analgesic effect. These results were also comparable to those of indomethacin, the reference drug used in this study. Since the plant extract reduced significantly the formation of oedema induced by carrageenan and histamine as well as reduced the number of writhes in acetic acidinduced writhing models and dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin, it is concluded that the use of M. parviflora for the treatment of inflammed purulent wounds, swellings, bruises and broken limbs may have been justified.

Plant Extracts as Alternative Therapeutic Agents for Anaemia: A Review

“…The haematological parameters were measured and reported that increase in level of PCV (60%), RBC (8*10/mm 3 ) and HB conc. (18) etc.in rats which were treated with dose 800mg/kg, as compared to other group of rats. [18]…”

Analgesic and anti-inflammatory activity of ethanolic extracts of leaf and fruit pulp of Aegle marmelos in albino rats

“…The reaction time was taken as the interval from the instant animal reached the hot plate until the moment animal licked its feet or jumped out. Percentage increase (change) in reaction time (I%), was derived, using the formula: I% = {(It - Acetic acid induced writhing 12,13 The drugs were administered orally one hour prior to the injection of acetic acid to groups. Writhing in rats was later induced by an IP injection of 0.7% (v/v) aqueous acetic acid at a dose of 10ml/kg body weight.…”

Assessment of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, total antioxidant activity, ferric reducing power and phytochemical analysis of methanolic extract of Malva parviflora

“…M. parviflora has been used in the mountain kingdom of Lesotho and many parts of the world to alleviate various symptoms of diseases. Whole plant of M. parviflora has been used to treat pain, inflammation, abscesses, liver injuries, swellings, boils and soften tumors (Singh and Navneet, 2017;Altyar et al, 2022;Islam et al, 2010;Afolayan et al, 2010). Tea prepared from the leaves of M. parviflora is used to alleviate dry coughs, bronchitis, profuse menstruation and also applied as taenicide (Singh et al, 2017;Ishtiaq et al, 2012).…”