Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanism

Valério, Daniel Augusto Rodrigues; Cunha, Thiago M.; Arakawa, Nilton Syogo; Lemos, Henrique; Costa, Fernando B. Da; Parada, Carlos A.; Ferreira, Sérgio Henrique; Cunha, Fernando Q.; Verri, Waldiceu A.

doi:10.1016/j.ejphar.2007.01.029

Cited by 114 publications

(95 citation statements)

References 46 publications

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“…To determine neutrophil migration to the peritoneal cavity, total cell counts were performed using a cell counter (Coulter AC T series analyzer; Coulter Corporation, Miami, Florida, USA) and differential cell counts were carried out on cytocentrifuge slides (Cytospin 3; Shandon Southern Products, Astmoore, UK) stained by the May-Grümwald-Giemsa (Rosenfeld) method. 35 The results were expressed as the number of neutrophils × 10 6 per peritoneal cavity. Cell-Cell Adhesion Assay.…”

Section: 34mentioning

confidence: 99%

Ginsenosides Inhibit HMGB1-induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Lee¹,

Ku²,

Jeong³

et al. 2014

Bulletin of the Korean Chemical Society

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Asian ginseng is used as a treatment for cardiovascular diseases, ischemia, and cancers. High mobility group box 1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. However, the effect of ginsenosides from Asian ginseng on HMGB1-induced inflammatory responses has not been studied. We addressed this question by monitoring the effects of ginsenoside treatment on lipopolysaccharide (LPS) and cecal ligation and puncture (CLP)-mediated release of HMGB1, and HMGB1-mediated regulation of proinflammatory responses. Ginsenoside treatment suppressed LPS-mediated release of HMGB1 and HMGB1-mediated cytoskeletal rearrangements. Ginsenosides also inhibited HMGB1-mediated inflammatory responses. In addition, ginsenosides inhibited the production of tumor necrosis factor-α (TNF-α) and activation of protein kinase B (Akt), nuclear factor-κB (NF-κB), and extracellular-regulated kinases (ERK) 1/2 by HMGB1. Ginsenosides also decreased CLP-induced release of HMGB1, production of interleukin (IL) 1β/6, and mortality. These results suggested that ginsenosides may be potential therapeutic agents for treatment of vascular inflammatory diseases through inhibition of the HMGB1 signaling pathway.

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Section: 34mentioning

confidence: 99%

Ginsenosides Inhibit HMGB1-induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Lee¹,

Ku²,

Jeong³

et al. 2014

Bulletin of the Korean Chemical Society

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“…In order to discard possible non-specific muscle relaxant or sedative effects of T. sinapou, the mice motor performance was evaluated on the rota-rod test (Valério et al, 2007). The apparatus consisted of a bar with a diameter of 2.5 cm, subdivided into 6 compartments by disks 25 cm in diameter (Ugo Basile, Model 7600).…”

Section: Measurement Of Motor Performancementioning

confidence: 99%

Tephrosia sinapouethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFαand IL-1βproduction

Martínez¹,

Zarpelon²,

Cardoso³

et al. 2013

Pharmaceutical Biology

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Context: Tephrosia toxicaria is currently known as Tephrosia sinapou (Buc'hoz) A. Chev. (Fabaceae) and is a source of compounds such as flavonoids that inhibit inflammatory pain. Objective: To investigate the analgesic effect and mechanisms of the ethyl acetate extract of T. sinapou in inflammatory pain in mice. Materials and methods: Behavioral responses were evaluated using mechanical (1-24 h) and thermal hyperalgesia (0.5-5 h), writhing response (20 min) and rota-rod (1-5 h) tests. Neutrophil recruitment (myeloperoxidase activity), cytokines (tumor necrosis factor [TNF]a and interleukin [IL]-1b), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels were determined by colorimetric assays. Pharmacological treatments were opioid receptor antagonist (naloxone, 0.1-1 mg/kg) and control opioid (morphine, 5 mg/kg). Inflammatory stimuli were carrageenin (100 mg/paw), complete Freund's adjuvant (CFA, 10 ml/paw), prostaglandin E 2 (PGE 2 , 100 ng/paw) and acetic acid (0.8%). Results: The intraperitoneal pre-treatment with extract inhibited in a dose-dependent (30-300 mg/kg) dependent manner the mechanical hyperalgesia induced by carrageenin (up to 93% inhibition). The post-treatment (100 mg/kg) inhibited CFA-induced hyperalgesia (up to 63% inhibition). Naloxone (1 mg/kg) prevented the inhibitory effect of the extract over carrageenin-induced mechanical (100%) and thermal (100%) hyperalgesia, neutrophil recruitment (52%) and TNFa (63%) and IL-1b (98%) production, thermal threshold in naïve mice (99%), PGE 2 -induced mechanical hyperalgesia (88%) and acetic acid-induced writhing response (49%). There was no significant alteration in the rota-rod test, and AST and ALT serum levels by extract treatment. Discussion and conclusion: Tephrosia sinapou ethyl acetate extract reduces inflammatory pain by activating an opioid receptor-dependent mechanism.

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“…For example, some monoterpenes, such as α-pinene and β-pinene, are common among angiosperms, and quantitative variations in these compounds may be a diagnostic feature for distinguishing between species (Harborne and Turner 1984). The species Aldama arenaria and A. robusta belong to Asteraceae family (Magenta and Pirani 2014) and are easily confused in herbalized materials, being only distinguished based on pollen features (Magenta 2006 Additionally, phytochemical studies have demonstrated the biological activity of root compounds from Aldama arenaria (Tirapelli et al 2002, Hipolito et al 2009, Porto et al 2009) and A. robusta (Tirapelli et al 2002, Valerio et al 2007.…”

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confidence: 99%

Seasonal variation of the essential oil from two Brazilian native Aldama La Llave (Asteraceae) species

Oliveira

Bombo

Oliveira

et al. 2016

An. Acad. Bras. Ciênc.

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Aldama arenaria and A. robusta are morphologically similar aromatic species that have seasonal development. The yield and chemical composition of essential oils from aerial and underground vegetative organs of these species were compared to verify the production of volatile metabolites in flowering and dormant phases of development and to identify if there are unique compounds for either species. The major compound in the essential oils from A. arenaria leaves was palustrol (16.22%) and for aerial stems was limonene (15.3%), whereas limonene (11.16%) and α-pinene (19.64%) were the major compounds for leaves and aerial stems from A. robusta, respectively. The major compound for the underground organs was α-pinene, in both species and phenological stages. High amounts of diterpenes were found especially for A. arenaria essential oils. Each analyzed species presented unique compounds, which can provide a characteristic chemical profile for both species helping to solve their taxonomic problems. This study characterized for the first time the yield and essential oil composition of A. arenaria and A. robusta, which have medicinal potential, and some of the compounds in their essential oils are unique to each one and may be useful in helping the correct identification of them.

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Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanism

Cited by 114 publications

References 46 publications

Ginsenosides Inhibit HMGB1-induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Ginsenosides Inhibit HMGB1-induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Tephrosia sinapouethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFαand IL-1βproduction

Seasonal variation of the essential oil from two Brazilian native Aldama La Llave (Asteraceae) species

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