Anti-inflammatory and Analgesic Effects of Ketoprofen in Palm Oil Esters Nanoemulsion

Sakeena, M. H. F.; Yam, Mun Fei; Elrashid, S. M.; Munavvar, A. S.; Azmin, M. N.

doi:10.5650/jos.59.667

Cited by 14 publications

(1 citation statement)

References 16 publications

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“…Demand for nonprescription drugs, such as 2-(3-benzoylphenyl)-propanoic acid (ketoprofen, KP) is expected to increase in the near future. KP is a nonsteroidal anti-inflammatory drug, widely used for the treatment of various kinds of pains, rheumatoid arthritis and osteoarthritis [ 1 ]. KP exhibits analgesic and antipyretic activity, which is mainly caused by the inhibition of prostaglandin synthesis by inhibiting cyclooxygenase [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Bogdanowicz

Niedziałkowski

Sobaszek

et al. 2018

Sensors

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In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.

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Section: Introductionmentioning

confidence: 99%

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Bogdanowicz

Niedziałkowski

Sobaszek

et al. 2018

Sensors

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Unusual human serum albumin fibrillation inhibition by ketoprofen and fenoprofen: Mechanistic insights

Prasanthan

Kishore

2021

J of Molecular Recognition

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Development of efficient therapeutic strategies to combat protein misfolding and fibrillation is of great clinical significance. In the current study, efforts have been made to obtain qualitative and quantitative insights into interactions of anti‐inflammatory drugs; ketoprofen and fenoprofen with the transport protein HSA and their inhibitory action on fibrillation by employing a combination of calorimetric, spectroscopic, microscopic, and molecular docking methods. Interestingly, both ketoprofen and fenoprofen are able to completely inhibit fibrillation of HSA when added at a concentration of 0.5 mM for fenoprofen or 1 mM ketoprofen. Further, no amorphous aggregates are formed. Isothermal titration calorimetric studies highlight the predominant role of polar interactions of these drugs with protein in prevention of fibrillation. The role of conformational flexibility of benzoyl and phenoxy groups of drugs has been correlated with inhibition efficiency. Such studies highlight the role of functionality required for an inhibitor in addressing neurodegenerative diseases.

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Potential therapeutic effect of Chrysopogon zizanioides (Vetiver) as an anti-inflammatory agent

Grover¹,

Behl

Bungău

et al. 2021

Environ Sci Pollut Res

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Anti-inflammatory and Analgesic Effects of Ketoprofen in Palm Oil Esters Nanoemulsion

Cited by 14 publications

References 16 publications

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe

Unusual human serum albumin fibrillation inhibition by ketoprofen and fenoprofen: Mechanistic insights

Potential therapeutic effect of Chrysopogon zizanioides (Vetiver) as an anti-inflammatory agent

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