Anti-inflammatory and analgesic effects of methanol extract and fractions of <i>Acalypha wilkesiana</i> leaves

Olukunle, J. O.; Adenubi, Olubukola Tolulope; Biobaku, K. T.; Sogebi, E. A. O.

doi:10.1515/jbcpp-2013-0079

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Leaves extract NT Suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandins E2 (PGE 2 ), and inducible nitric oxide synthase (iNOS) productions, and cyclooxygenase-2 (COX-2) expression in RAW 264.7 cells; also reduced secretion of tumour necrosis factor-alpha (TNF-α), interleukins 1beta (IL-1β), and IL-6 in LPS-stimulated RAW 264.7 cells [290]; also attenuated carrageenin-induced inflammation/oedema [291,292].…”

Section: Acalypha Wilkesianamentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants. Thus far, more than 900 medicinal plants have been recorded in the tropical region alone, and many of them are associated with diverse ethnomedicinal uses that belong to the traditional owners of Aboriginal people. In our effort to find anti-inflammatory lead compounds in collaboration with Aboriginal communities from their medicinal plants, we reviewed 78 medicinal plants used against various inflammation and inflammatory-related conditions by Aboriginal people. Out of those 78 species, we have included only 45 species whose crude extracts or isolated pure compounds showed anti-inflammatory properties. Upon investigating compounds isolated from 40 species (for five species, only crude extracts were studied), 83 compounds were associated with various anti-inflammatory properties. Alphitolic acid, Betulinic acid, Malabaric acid, and Hispidulin reduced proinflammatory cytokines and cyclooxygenase enzymes (COX-1 and 2) with IC50 values ranging from 11.5 to 46.9 uM. Other promising anti-inflammatory compounds are Brevilin A (from Centipeda minima), Eupalestin, and 5′-methoxy nobiletin (from Ageratum conyzoides), Calophyllolide (from Calophyllum inophyllum), and Brusatol (from Brucea javanica). D. polyandra is one example of an Aboriginal medicinal plant from which a novel anti-inflammatory benzoyl ester clerodane diterpenoid compound was obtained (compound name not disclosed), and it is in the development of topical medicines for inflammatory skin diseases. Medicinal plants in the tropics and those associated with indigenous knowledge of Aboriginal people could be a potential alternative source of novel anti-inflammatory therapeutics.

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Section: Acalypha Wilkesianamentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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“…Acalypha wilkesiana , which belongs to the spurge family ( Euphorbiaceae ), is a medical and ornamental plant widely distributed around the world, especially in the tropics of Africa. The leaves of A. wilkesiana have been employed in folk medicines for the treatment of many ailments [ 30 , 31 ]. A previous phytochemical analysis indicated the presence of alkaloids, tannins, triterpenoids, sesquiterpenoids, and polyphenols in A. wilkesiana extract, which was shown to have analgesic, antipyretic, antibacterial, and anti-inflammatory activities [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory Effect of a Polyphenol‐Enriched Fraction from Acalypha wilkesiana on Lipopolysaccharide‐Stimulated RAW 264.7 Macrophages and Acetaminophen‐Induced Liver Injury in Mice

Wu¹,

Pang²,

Chen³

et al. 2018

Oxidative Medicine and Cellular Longevity

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A polyphenol-enriched fraction (PEF) from Acalypha wilkesiana, whose leaves have been traditionally utilized for the treatment of diverse medical ailments, was investigated for the anti-inflammatory effect and molecular mechanisms by using lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages and acetaminophen- (APAP-) induced liver injury mouse model. Results showed that PEF significantly attenuated LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production and suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in RAW 264.7 macrophages. PEF also reduced the secretion of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin- (IL-) 1β, and IL-6 in LPS-stimulated RAW 264.7 macrophages. Moreover, PEF potently inhibited LPS-induced phosphorylation of mitogen-activated protein kinases (MAPKs) as well as the activation of nuclear factor-κB (NF-κB) by preventing the degradation of inhibitor κB-α (IκB-α). In vivo, PEF pretreatment ameliorated APAP-induced liver injury and hepatic inflammation, as presented by decreased hepatic damage indicators and proinflammatory factors at both plasma and gene levels. Additionally, PEF pretreatment remarkably diminished Toll-like receptor 3 (TLR3) and TLR4 expression and the subsequent MAPKs and NF-κB activation. HPLC analysis revealed that two predominantly polyphenolic compounds present in PEF were geraniin and corilagin. These results indicated that PEF has an anti-inflammatory effect, and its molecular mechanisms may be involved in the inactivation of the TLR/MAPK/NF-κB signaling pathway, suggesting the therapeutic potential of PEF for inflammatory diseases.

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Safety evaluation of Acalypha wilkesiana in albino rats and BHK-21 cell line

et al. 2016

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Anti-inflammatory and analgesic effects of methanol extract and fractions of Acalypha wilkesiana leaves

Abstract: This study suggested that A. wilkesiana leaves have anti-inflammatory and analgesic potential comparable with those of standard drugs.

Cited by 5 publications

References 8 publications

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Anti‐Inflammatory Effect of a Polyphenol‐Enriched Fraction from Acalypha wilkesiana on Lipopolysaccharide‐Stimulated RAW 264.7 Macrophages and Acetaminophen‐Induced Liver Injury in Mice

Safety evaluation of Acalypha wilkesiana in albino rats and BHK-21 cell line

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