Anti-inflammatory and analgesic effects of two new flavone C-glycosides from Panzeria alaschanica

Wang, Qinghu; Wu, Jiesi; Wu, Xiujie; Tai, Wenquan; Nakamura, Dai; Wu, Ruo-bin; Han, Narenchaoketu

doi:10.1007/s00706-015-1414-y

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Compound 227 had a higher anti-inflammatory potential than diclofenac (5 mg/kg b. w.), while the activity of compounds 139 and 140 were similar at 20-50 mg/kg b. w. doses. The butanol extract of this species furnished 2 other potentially anti-inflammatory compounds: the flavone C-glycosides panzeroside A (156) and B (157) [173]. A paw edema reduction volume in rats equal to that of 5 mg/kg b. w. of diclofenac was achieved with 30 mg/kg b. w. of both compounds.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

2019

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The genus Ballota, belonging to Lamiaceae family (Stachyoideae/ Lamioideae subfamily) [1,2], is, apart from the South African endemic species Ballota africana (L.) Benth., naturally distributed in the Mediterranean, the Middle East and in North Africa. Some species (e.g., Ballota nigra L. s. l.) are also present over large areas of western, central, and northern Europe, and 4 species, whose status will be discussed later, in Somalia.Ballota species are perennial herbs or small shrubs with branched and/or simple hairs, toothed and petiolate leaves, the inflorescence thyrsoid or racemoid sometimes has long and spinose bracteoles (sect. Acanthoprasium), and the calyx is mostly campanulate, purple to white.A former classification of the genus identified the occurrence of 31 species (1 = Ballota integrifolia Benth. -2 = Ballota wettsteinii Rech. pat. -3 = Ballota frutescens (L.) Woods -4 = Ballota fruticosa Baker -5 = Ballota somala Patzak -6. Ballota andreuzziana Pamp. -7 = Ballota acetabulosa (L.) Benth. -8 = Ballota undulata (Sieb, ex Fres.) Benth. -9 = Ballota pseudodictamnus (L.) Benth. -10 = Ballota damascena Boiss. -11 = Ballota hildebrandtii Vatke et Kurtz -12 = Ballota hirsuta Benth. -13 = Ballota bullata Pomel -14 = B. africana (L.) Benth. -15 = Ballota aucheri Boiss. -16 = Ballota macrodonta Boiss. et Bal. -17 = Ballota larendana Boiss. et Heldr. -18 = Ballota rotundifolia C. Koch -19 = Ballota rupestris (Biv.) Vis. -20 = Ballota macedonica Vand. -21 = Ballota kaiseri V. Täckh. -22 = Ballota antilibanotica Post -23 = Ballota cristata Davis -24 = Ballota semanica Rech. f. -25 = Ballota labillardieri Briq. -26 = Ballota saxatilis Sieb. ex J. et C. Presl -27 = Ballota stachydiformis Höchst. -28 = Ballota philistea Bomm. -29 = Ballota platylomaThe 2 genera Ballota and Otostegia, belonging to the Lamiaceae family, are closely related taxonomically and found mainly in the Mediterranean area, Middle East, and North Africa. Since ancient times, they have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Phytochemical investigations of Ballota and Otostegia species have revealed that diterpenoids are the main constituents of the genera. A large number of flavonoids and other metabolites were also identified. This review, covering literature from 1911 up to 2018, includes traditional uses, chemical profiles (both of volatile and nonvolatile metabolites), and biological properties of all the taxa of these 2 genera studied to date.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…B. lanata L.), 2 new flavone C-glycosides, named panzeroside A (156) and B (157), were isolated. The 2 new compounds demonstrated significant and dose-dependent analgesic and anti-inflammatory effects [173].…”

Section: Flavonoidsmentioning

confidence: 99%

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

2019

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“…However, there are few reported pharmacological studies [14] to support the therapeutic and medicinal effects of P. Alaschanica, and the mechanism of its beneficial effects has yet to be demonstrated. Previous phytochemical studies have revealed that P. alaschanica contains two new flavonoids, glycosides and phenylethanoids [15][16]. In this study, we investigated the effects of P. alaschanica as an anti-inflammatory candidate to inhibit paw edema formation in carrageenan-induced rat models of acute inflammation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Panzeria Alaschanica Kupr. on Carrageenan-Induced Acute Inflammation in Rats

Ha La Tu,

Tumurbaatar,

Chimedtseren

et al. 2023

Cent. Asian j. Med. Sci.

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Objectives: In the present study, we aimed to investigate the effect of Panzeria alaschanica Kupr. (P. alaschanica) on carrageenan-induced acute inflammation in rats. Method: Carrageenan-induced rat paw edema was used to evaluate the anti-inflammatory activity. P. alaschanica extract (32, 64, and 160 mg/kg/ BW) or vehicle was given orally 60 minutes before the subplantar injection of carrageenan. Ibuprofen (100 mg/kg) was used as a standard drug. The carrageenan-injected paw was measured 30, 60, 120, 180, and 240 minutes after the carrageenan injection. The levels of serum tumor necrosis factor (TNF)-α, interleukin (IL)-ELISA measured 1β, and IL-6. Results: The P. alaschanica at all given doses significantly (p˂0.01) inhibited carrageenan-induced rat paw edema. Moreover, it significantly reduced TNF-α, IL-1β, and IL-6 serum levels at different doses (p˂0.01). The anti-inflammatory effect of P. alaschanica was comparable to ibuprofen. Conclusion: P. alaschanica has an anti-inflammatory impact on carrageenan-induced paw edema in rats. The mechanism of action may partly be via reducing the levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.

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“…Recent studies have reported that P. lanata contains approximately 20 secondary metabolites including flavonoids, organic acids, and alkaloids [2–10]. Among them, flavonoids were the main bioactive components according to the recent studies such as the anti‐inflammatory and analgesic activities [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Chemical profiling and multicomponents quantitative analysis of Panzerina lanata by ultra‐fast liquid chromatography with tandem mass spectrometry

Zheng

Zhao

et al. 2021

J of Separation Science

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Panzerina lanata is a Chinese medicine with the bioactivity of detumescence and detoxification. In this study, novel qualitative and quantitative methods were established by ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry and ultra‐high‐performance liquid chromatography‐triple quadrupole linear ion trap mass spectrometry, respectively. As a result, 20 compounds were identified or tentatively characterized including flavonoids, organic acids, alkaloids, and lignans, five of which were identified for the first time based on the reference standards. The quantitative approach exhibited good linearity (R2 > 0.995), precision (RSDs < 4.97%), stability (RSDs < 4.77%), and recovery (96.04‐104.14%). Afterward, this method was implemented to determine 11 flavonoids in four batches of P. lanata. Among them, seven compounds were quantified for the first time. Narcissin was abundant in each batch of P. lanata (average of 10.890‐14.230 mg/g) with the highest quantities. The results provide valuable information for quality evaluation.

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Anti-inflammatory and analgesic effects of two new flavone C-glycosides from Panzeria alaschanica

Cited by 5 publications

References 12 publications

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

Effect of Panzeria Alaschanica Kupr. on Carrageenan-Induced Acute Inflammation in Rats

Chemical profiling and multicomponents quantitative analysis of Panzerina lanata by ultra‐fast liquid chromatography with tandem mass spectrometry

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