Anti-inflammatory and anti-apoptotic effects of Crataegus oxyacantha on isoproterenol-induced myocardial damage

Vijayan, Navin Alukkathara; Mohana, Thiruchenduran; Devaraj, S. Niranjali

doi:10.1007/s11010-012-1251-9

Cited by 29 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AEC most likely achieves its myocardial protection by reducing nitritive stress and oxidative stress and decreasing apoptosis. This conclusion is supported by reduced iNOS expression, nitrite levels, downregulated COX-2, decreased lipid peroxidation, decreased release of cytochrome c, and protection of DNA fragmentation [37]. Besides, hawthorn extract inhibited N-formyl-Met-Leu-Phe (FMLP-) induced superoxide anion generation, elastase release, and chemotactic migration and reduced leukotriene B4 production and lipopolysaccharide-induced generation of TNF- α and IL-8.…”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

show abstract

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Preparations of Crataegus are used in minor forms of coronary heart disease, heart failure, and cardiac arrhythmia. Crataegus has antioxidant (13, 14), positive inotropic (15), anti-inflammatory (16, 17), anti-cardiac remodeling (18), antiplatelet aggregation (19, 20), vasodilating (21-23), endothelial protective (24), smooth muscle cell migration and proliferation-reducing (25), ischemia/reperfusion injury protective (26, 27), lipid-lowering (28, 29), arterial blood pressure-decreasing (30, 31), and antiarrhythmic effects (8-10). Although some species of Crataegus have been shown to prevent cardiac arrhythmias induced by aconitine, calcium chloride, adrenaline (32), and the ischemic process (10), its antiarrhythmic effect on digoxin-induced arrhythmias has not yet been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in rats

Alp¹,

Soner²,

Baysal³

et al. 2015

Anatol J Cardiol

View full text Add to dashboard Cite

Objective:Digitalis preparations are commonly used by children and adults with heart diseases worldwide, although excessive doses may cause cardiac effects. The aim of the study is to evaluate the antiarrhythmic effect of Crataegus oxyacantha extract on digoxin-induced arrhythmias in anesthetized Wistar rats.Methods:Control and experimental groups were evaluated for arrhythmias induced by digoxin. Fifteen rats (7 as controls and 8 as the experimental group) were included in the study. The dry fruits of 100 mg Crataegus oxyacantha were extracted by percolation method. Digoxin, at a dose of 40 μg/kg/min, was infused to form the arrhythmias in all rats. Simultaneously, the extract was infused into the experimental group, while 0.9% NaCl was infused into control group. Electrocardiographic QRS prolongation and arterial blood pressure changes were analyzed.Results:The experimental group lived longer (62.13±2.20 min) than the controls (p=0.002). On the other hand, the time to beginning of QRS prolongation did not differ between the two groups (p=0.812). Bradycardia was significant in the control group (288.01±10.54 beat/min and p=0.01). The maximum QRS duration was observed in the control group during the digoxin and 0.9% NaCl infusion period (53.29±3.99 ms and p=0.001). Also, the durations of atrial and ventricular arrhythmias were shorter in the experimental group. However, arterial blood pressure dipping was significant in the experimental group (23.67±10.89 mm Hg and p<0.001).Conclusion:Crataegus oxyacantha alcoholic extract produced an antiarrhythmic effect that was induced by digoxin in Wistar rats. However, in the clinical use of this extract, the hypotensive effect should be considered. Also, the alcoholic extract of Crataegus oxyacantha may be an alternative treatment medication for arrhythmias induced by digoxin toxicity in humans.

show abstract

“…Hawthorn has proved be a potent antioxidant and medicinal plant because it has compounds as epicatechins, triterpene, saponins, oligomeric procyanidins, chlorogenic acid, flavonoids and flavon Cglycosides (isoquerecitrin, hyperoside, orientin, isoorientin, quercetin, quercitrin, vitexin, isovitexin and rutin) (Konieczynski, 2015;Rigelsky and Sweet, 2002). Hawthorn has shown various therapeutic effects as mainly hypolipidemic, anti-inflammatory, immunomodulatory, digestive modulator, antimicrobial, antianxiety, antioxidant, cardiac stimulant and hypotensive agent (Benmalek et al, 2013;Elango and Devaraj, 2010;Vijayan et al, 2012). Most studies have focused on the use in cardiovascular diseases for their effectiveness in cardiac therapy.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, hypolipidemic and preventive effect of Hawthorn (Crataegus oxyacantha) on alcoholic liver damage in rats

Martínez-Rodríguez¹,

Estrada²,

Gutiérrez-Hernández³

et al. 2016

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

The use of alcoholic beverages is more common and accepted by our society despite the health risks. Alcohol catabolism produces free radicals that cause oxidative stress and damage in liver principally. Hawthorn (Crataegus oxyacantha) is a medicinal plant that has been shown to have wide variety of polyphenolic compounds with antioxidant and hypolipidemic effect. The objective of this study was the evaluation of Hawthorn methanol extract as preventive treatment in alcoholic damage. A rat model of chronic alcoholic intake was generated with the administration of 3 g/kg/day in two times with 35 % ethanol for twelve weeks to evaluate the protective effect of 50 mg/kg/day for twelve weeks of Hawthorn administration by the determination of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltranspeptidase (γ-GT), acid phosphatase (ACP), total bilirubin, liver glycogen, lipid peroxidation, serum total antioxidant capacity (TAC), total cholesterol, triglycerides, low density lipoproteins (LDL), and high density lipoproteins (HDL) levels in blood and hepatic tissues. Oxidative stress was evaluated by lipid peroxidation through MDA and TAC in the serum of animals. Lipid profile and glycogen was measured by LDL, HDL and glycogen concentration, respectively. Histological tissue cuts were visualized by hematoxylin eosin and Masson trichrome staining. Hawthorn treatment decreased AST, ALT, γ-GT and ACP activity in liver damage with a decrease of total bilirubin and an increase of liver glycogen stores in rats administrated with alcohol. Hawthorn showed an antioxidant and preventive effect decreasing liver lipid peroxidation levels and increasing serum TAC evidencing a hypolipidemic effect decreasing total cholesterol, triglycerides and LDL levels without affecting HDL levels. Our results indicate that Hawthorn exhibited a protective effect against liver damage in rats with chronic alcohol administration providing a possible alternative treatment for alcohol liver damage.

show abstract

Anti-inflammatory and anti-apoptotic effects of Crataegus oxyacantha on isoproterenol-induced myocardial damage

Cited by 29 publications

References 31 publications

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Protective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in rats

Antioxidant, hypolipidemic and preventive effect of Hawthorn (Crataegus oxyacantha) on alcoholic liver damage in rats

Contact Info

Product

Resources

About