Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase

Gupta, O.P.; Sing, Seema; Bani, Sarang; Sharma, Neha; Malhotra, S.; Gupta, B. K.; Banerjee, S.; Handa, S. S.

doi:10.1016/s0944-7113(00)80017-3

Cited by 104 publications

(53 citation statements)

References 5 publications

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“…These activities of the SC extract may probably be due to the presence of flavonoids in the extract, since these substances isolated from Myrtaceae species, including SC, are known to exert a potent inhibitory effect on a variety of enzymes related to cell activation and to the production of inflammatory mediators (35,36). Some isolated flavonoids possess anti-inflammatory (37), antiallergic (38) and analgesic (39) activities; however, few flavonoids from SC leaves (23,27) and flowers have been isolated or identified (40).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Brito

Lima

Ramos

et al. 2007

Braz J Med Biol Res

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Myrtaceae is a plant family widely used in folk medicine and Syzygium and Eugenia are among the most important genera. We investigated the anti-allergic properties of an aqueous leaf extract of Syzygium cumini (L.) Skeels (SC). HPLC analysis revealed that hydrolyzable tannins and flavonoids are the major components of the extract. Oral administration of SC (25-100 mg/kg) in Swiss mice (20-25 g; N = 7/group) inhibited paw edema induced by compound 48/80 (50% inhibition, 100 mg/kg; P ≤ 0.05) and, to a lesser extent, the allergic paw edema (23% inhibition, 100 mg/kg; P ≤ 0.05). SC treatment also inhibited the edema induced by histamine (58% inhibition; P ≤ 0.05) and 5-HT (52% inhibition; P ≤ 0.05) but had no effect on plateletaggregating factor-induced paw edema. SC prevented mast cell degranulation and the consequent histamine release in Wistar rat (180-200 g; N = 7/group) peritoneal mast cells (50% inhibition, 1 µg/mL; P ≤ 0.05) induced by compound 48/80. Pre-treatment of BALB/c mice (18-20 g; N = 7/group) with 100 mg/kg of the extract significantly inhibited eosinophil accumulation in allergic pleurisy (from 7.662 ± 1.524 to 1.89 ± 0.336 x 10 6 /cavity; P ≤ 0.001). This effect was related to the inhibition of IL-5 (from 70.9 ± 25.2 to 12.05 ± 7.165 pg/mL) and CCL11/eotaxin levels (from 60.4 ± 8.54 to 32.8 ± 8.4 ng/mL) in pleural lavage fluid, using ELISA. These findings demonstrate an anti-allergic effect of SC, and indicate that its anti-edematogenic effect is due to the inhibition of mast cell degranulation and of histamine and serotonin effects, whereas the inhibition of eosinophil accumulation in the allergic pleurisy model is probably due to an impairment of CCL11/eotaxin and IL-5 production.

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Section: Discussionmentioning

confidence: 99%

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Brito

Lima

Ramos

et al. 2007

Braz J Med Biol Res

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“…In the present study, silymarin significantly reduced the serum NF-κB, TNF-α, IL-1β and IL-6 levels in the lungs of I/R-injured rats. A previous study demonstrated that silymarin suppressed inflammation in mycobacterial adjuvant-induced arthritis (19) and in the skin of SENCAR mice (20). Silymarin may therefore represent a potent agent for protection against the lung I/R-induced inflammatory response.…”

mentioning

confidence: 94%

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Jin

Zhao

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Silymarin is a traditional therapeutic used to protect the liver, acting to oppose lipid peroxidation, to enhance liver regeneration and functioning as an antioxidant. However, the effects of silymarin on pulmonary vascular dysfunction have not been investigated. In the present study, the modulatory effects of silymarin on pulmonary vascular dysfunction and the underlying mechanisms behind this were investigated in a lung ischemia-reperfusion (I/R) injury rat model. Male Sprague Dawley rats were randomly divided into 3 groups, including: i) A control group (n=10); ii) an I/R group (n=10); and iii) a silymarin-treated group (n=10). All experimental rats received 250 mg/kg/day of silymarin for 8 days. Silymarin was demonstrated to markedly improve lung I/R-induced pulmonary vascular dysfunction and lung moisture. Following silymarin treatment, inflammation and oxidative stress in the lung I/R-injury rats were demonstrably suppressed. Treatment with silymarin also inhibited the activation of caspase-3 and -9, and hypoxia inducible factor-1α (HIF-1α) and inducible nitric oxide synthase (iNOS) protein expression in the lung I/R-injury rats. Silymarin was concluded to impact upon pulmonary vascular dysfunction through the HIF-1α-iNOS pathway in the lung I/R injury rat model.

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“…Silymarin is a mixture of flavonolignans derived from the plant Silybum marianum (milk thistle) that is known for its hepatoprotective, anti-inflammatory and antioxidant properties (Gupta et al, 2000;Giese, 2001;Wu et al, 2011). The active component of silymarin is silybin and its concentration can vary greatly between silymarin extracts, thereby potentially affecting its biological effects.…”

Section: Introductionmentioning

confidence: 99%

Providing the plant extract silymarin to lactating sows: effects on litter performance and oxidative stress in sows

Farmer

Lapointe

Cormier

2017

Animal

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Silymarin is an extract from the plant milk thistle that was shown to have antioxidant and hyperprolactinemic properties. Taking into account the essential role of prolactin for lactating sows and the systemic oxidative stress occurring during lactation, it is of interest to investigate the potential beneficial effects of silymarin on lactating sows. A study was therefore carried out to determine the effects of providing either 1 or 8 g/day of the plant extract silymarin to lactating sows. Sows in first, second or third parity were fed conventional diets during gestation and, at farrowing, were assigned as controls (CTL, n = 33), or were fed 1 g/day (SYL1, n = 33) or 8 g/day (SYL8, n = 33) of silymarin. The silymarin was provided in two equal amounts per day, and was fed throughout a 20-day lactation. The performance of sows and their litters was assessed and circulating concentrations of prolactin (days 7 and 18), urea (days 7 and 18) and oxidative status, via protein carbonyls and superoxide dismutase activity (day 18), were measured in sows. Milk samples were obtained on day 18 to measure standard composition. There was no effect of silymarin ( P > 0.10) on circulating prolactin or urea, or on oxidative damage to proteins or antioxidant potential in sows. Lactation feed intake, backfat and BW of sows were unaffected by treatment ( P > 0.10) as was the case for milk composition and piglet growth ( P > 0.10). Results demonstrate that providing up to 8 g/day of the plant extract silymarin to lactating sows had no beneficial effects in terms of circulating prolactin concentrations or oxidative status of sows, or in terms of performances of sows and their litters.

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Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase

Cited by 104 publications

References 5 publications

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Providing the plant extract silymarin to lactating sows: effects on litter performance and oxidative stress in sows

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