Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f.

Babu, N. Prakash; Saravanan, S.; Pandikumar, P.; Krishna, K. Bala; Raj, M. Karunai; Ignacimuthu, S.

doi:10.1007/s00011-013-0681-5

Cited by 19 publications

(8 citation statements)

References 40 publications

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“…A direct engagement of lysosomal enzymes with connective tissue degrades its components such as collagen, protein‐bound carbohydrates, glycosaminoglycans and elastin and thus plays a prime role in alleviating the arthritic condition. Moreover, lysosomal glycohydrolases open up the collagen fibres for the direct action of collagenolytic enzymes which reflects the cartilage destruction with elevated levels of urinary hydroxyproline . Results obtained through our study are at par with the above findings.…”

Section: Discussionsupporting

confidence: 83%

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Murunikkara

Rasool

2014

Int J Rheum Dis

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Section: Discussionsupporting

confidence: 83%

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Murunikkara

Rasool

2014

Int J Rheum Dis

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“…This plant is also used as a traditional medicine in India, Bangladesh, Pakistan and surrounding areas, especially for joint pain medication. One study found that C. phlomidis leaf extract had anti-inflammatory and anti-arthritic activity using carrageenan-induced paw edema and arthritis induced with FCA (Freund complete adjuvant) in trial rats (Prakash et al 2014). Other studies also reported the same founding in the root extract of C. phlomidis using granuloma cotton pellet method (Parekar et al 2012).…”

Section: Discussionmentioning

confidence: 93%

Anti-inflammatory activities of ethnomedicinal plants from Dayak Abai in North Kalimantan, Indonesia

et al. 2017

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Paramita S, Kosala K, Dzulkifli D, Saputri DI, Wijayanti E. 2017. Anti-inflammatory activities of ethnomedicinal plants from Dayak Abai in North Kalimantan, Indonesia. Biodiversitas 18: 1556-1561. Inflammation is a normal process in the human body as a response to injury from the healing process. Meanwhile, chronic inflammation will cause new health problems to patients. Antiinflammatory drugs generally used for those conditions, have several side effects to patients. The objective of this research was to find alternative anti-inflammatory drugs, especially from natural sources. Three medicinal plants recorded from Dayak Abai in North Kalimantan, Indonesia for health problems caused by the inflammation process i.e. Amomum xanthophlebium Baker, Clerodendrum buchananii (Roxb.) Walp., and Donax canniformis (G.Forst.) K.Schum. were used as material in this research. The experimental method using carrageenan-induced rat paw edema was used followed by the resulting measurement using plethysmometer. The results showed that significant differences of AUC (area under the curve) with p = 0.001 (p < 0.05) were achieved between negative control, positive control, and treatment group with plant medicinal extracts. AUC of leaves ethanol extract of C. buchananii showed the strongest antiinflammatory activities. It could be concluded that the medicinal plants recorded from ethnomedicinal data from Dayak Abai in North Kalimantan, have anti-inflammatory activities, with C. buchananii as the most potential ones which could be further developed as a new source of the anti-inflammatory drug.

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“…In addition, HMSB could significantly down-regulate pro-inflammatory cytokines TNF, IL-1 and IL-6 protein levels and mRNA expression in the joints with a dose-dependent manner. 90 These results indicated that the HMSB possess considerable potency in anti-inflammatory action and has a prominent anti-arthritic effect. Panthong et al evaluated the anti-inflammatory and antipyretic activities of the methanol extract (at doses of 1.0, 2.0, 4.0 mg/ear, i.g.)…”

Section: Pharmacological Propertiesmentioning

confidence: 91%

“… Anti-inflammatory and anti-nociceptive activity 3-Hydroxy, 2-methoxy-sodium butanoate In vivo Carrageenan-induced inflammation and freund complete adjuvant (FCA)-induced arthritic rat models 25, 50, 100 mg/kg, i.g. Reduced the paw edema response, decrease lysosomal enzymes, protein-bound carbohydrates, and acute phase protein levels 90 Methanol extract from C. petasites In vivo Ethyl phenylpropiolate-induced ear edema and carrageenan-induced paw edema in rats 1, 2, 4 mg/ear, i.g. Inhibited prostaglandin synthesis 91 Ethanol extract from C. laevifolium in vitro lipoxygenase 10–1000 μg/ml Displayed the greatest inhibition capacity with the IC 50 value of 14.12 μg/ml 92 Methanolic extract from C. inerme In vivo Formalin induced hind paw edema animals 50, 100, 200 mg/kg, i.g.…”

Section: Pharmacological Propertiesmentioning

confidence: 98%

Traditional uses and pharmacological properties of Clerodendrum phytochemicals

Wang

Luan²,

et al. 2018

Journal of Traditional and Complementary Medicine

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Clerodendrum is a genus of ca. 500 species in the family Lamiaceae and widely distributed throughout the whole world. Up to now, many species of this genus have been described in various indigenous systems of medicine and are used in preparation of folklore medicines for the treatment of various life-threatening diseases, and more than eleven species of the Clerodendrum genus have been very well studied for their chemical constituents and biological activities, and 283 compounds, including monoterpene and its derivatives, sesquiterpene, diterpenoids, triterpenoids, flavonoid and flavonoid glycosides, phenylethanoid glycosides, steroids and steroid glycosides, cyclohexylethanoids, anthraquinones, cyanogenic glycosides, and others have been isolated and identified. Pharmacological studies have shown that these compounds and extracts from the Clerodendrum genus have extensive activities, such as anti-inflammatory and anti-nociceptive, anti-oxidant, anti-hypertensive, anticancer, antimicrobial, anti-diarrheal, hepatoprotective, hypoglycemic and hypolipidemic, memory enhancing and neuroprotective, and other activities. In this review, we attempt to highlight over phytochemical progress and list the phytoconstituents isolated from the genus Clerodendrum reported so far. The biological activities of this genus are also covered.

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Anti-inflammatory and anti-arthritic effects of 3-hydroxy, 2-methoxy sodium butanoate from the leaves of Clerodendrum phlomidis L.f.

Abstract: The 3-hydroxy,2-methoxy sodium butanoate isolated from plant leaves displays considerable potency in anti-inflammatory action and has a prominent anti-arthritic effect. This is the first report of this natural compound with bioactivity.

Cited by 19 publications

References 40 publications

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Anti-inflammatory activities of ethnomedicinal plants from Dayak Abai in North Kalimantan, Indonesia

Traditional uses and pharmacological properties of Clerodendrum phytochemicals

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