Anti-inflammatory and anti-arthritic properties of aqueous extract of Nauclea diderrichii (Rubiaceae) stem bark in rats

Mbiantcha, Marius; Djami, Marcelle Bejoutance; Ateufack, Gilbert; Atsamo, Donatien Albert; Tsafack, Gonzal Eric; Yousseu, William Nana; Djuichou, Flore Stéphanie Nguemnang; Matah, Vanessa Marthe Mba; Kenmogne, Liliane Kamdem; Adjouzem, Flore Carine; Ndjoya, Linda Fagni Zenab; Tiokeng, Giresse Lambou

doi:10.1007/s13596-020-00446-6

Cited by 2 publications

(4 citation statements)

References 40 publications

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“…It is known that several anti-infammatory substances have an efect on certain enzyme systems such as transaminases [4]. Te inhibition of transaminases observed with anti-infammatory substances could infuence the continued formation of polypeptide-kinins during the antiinfammatory process [48].…”

Section: Discussionmentioning

confidence: 99%

“…One hour after this treatment, each rat received (exception for the animals in the neutral control group) an injection of 2.5% formalin under the plantar aponeurosis of the left hind paw using a 1 mL syringe, then the diameter of the paw was measured 1 h, 2 h, 4 h, 8 h, and 24 h after formalin injection [41]. Te extent of edema was assessed by determining the percentage increase in the volume of the sole of the paw [4]. (1)…”

Section: Formalin-induced Acute Infammationmentioning

confidence: 99%

“…Te infammatory process, caused by tissue damage, infection, intense heat, or irritation, can be acute or chronic [1][2][3] with many phases of evolution (vascular, vasculoexudative, cellular, and resolution). In addition, the state of chronic infammation can lead to more complex pathologies such as rheumatoid arthritis and cancer [4].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Nana

Mimb

Atsamo

et al. 2023

International Journal of Inflammation

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In traditional Cameroonian medicine, to relieve many inflammations, parts of Vernonia guineensis, are very widely used. This study considered the evaluation of acute toxicity and anti-inflammatory properties of the hydroethanolic extract of the roots of Vernonia guineensis. In an acute toxicity study, 250, 2500, and 5000 mg/kg were administered orally to mice in a single dose, and general behavior, adverse effects, and mortality were monitored. In vitro and in vivo anti-inflammatory tests were performed, and then histological, serum, hematological, and oxidative stress parameters have been evaluated. In an acute toxicity, all groups revealed neither mortality nor any significant alteration in behavior; only drowsiness, sedation, and lethargy were observed at 5000 mg/kg. For in vitro tests, the extract inhibited anti-inflammatory activity. In the formalin test, at 250 mg/kg, the extract inhibited edema with a percentage of 56.41% (4th hour) in an acute treatment and 74.44% (10th day). Joint edema was reduced by 67.24% (24th hour) in a single treatment and by 74.25% (7th day) in repeated treatment. The extract caused an increase in red blood cell, hemoglobin, and serum protein levels and reduced the white blood cells as well as the activities of alkaline phosphatase and alanine aminotransferase. The extract modulated oxidative stress parameters in the brain, spinal cord, liver, and kidneys. The extract protected the joint by reducing the bone and cartilage erosion. The present work highlights the anti-inflammatory, antioxidant, and antianemic properties of the hydroethanolic extract of the roots of Vernonia guineensis, which supports its empirical use in traditional medicine for the treatment of inflammatory pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Formalin-induced Acute Infammationmentioning

confidence: 99%

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In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Nana

Mimb

Atsamo

et al. 2023

International Journal of Inflammation

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“…Nauclea diderrichii is a plant of the Rubiaceae family used folk in Cameroon in the treatment of anemia, fever, gastric ulcer, malaria, abdominal pain, skin infections, and diarrhea [ 10 ]. Scientific studies have shown that the extracts of this plant possess antiarthritic properties [ 11 ], antimalaria activities [ 12 ], and antileishmanian effects [ 13 ]. Phytochemical investigations have revealed the presence of phenols, triterpenes, sugars, alkaloids, tannins, glycosides, saponins, flavonoids, and cardiac glycosides [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Antisecretory and Spasmolytic Activities of Aqueous and Ethanolic Stem Bark Extracts of Nauclea diderrichii in Wistar Rats

Djimeli

Nchouwet

Kamani

et al. 2022

BioMed Research International

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Background. Diarrheal diseases are a major cause of morbidity and mortality throughout the world and particularly in developing countries. Nauclea diderrichii is a plant used in traditional medicine in the treatment of anemia, fever, gastric ulcer, malaria, abdominal pain, skin infections, and diarrhea. The present work is aimed at evaluating the antisecretory and spasmolytic activities of aqueous and ethanolic stem bark extracts of Nauclea diderrichii in Wistar rats. Methods. The effect of aqueous and ethanolic extracts of Nauclea diderrichii was tested at doses of 100, 200, and 300 mg/kg on castor oil-induced secretory diarrhea, misoprostol-induced fluid accumulation, and the effect of pretreatment with yohimbine and glibenclamide. They were also tested on normal motility and castor oil- and carbachol-induced hypermotility. Results. The results showed that the aqueous and ethanolic extracts of Nauclea diderrichii significantly ( p < 0.001 ) inhibited castor oil-induced secretory diarrhea at all the doses. Both extracts significantly ( p < 0.001 ) inhibit fluid accumulation induced by misoprostol. The pretreatment with glibenclamide reduced the antidiarrheal activity of aqueous extract of Nauclea diderrichii. The pretreatment with yohimbine did not alter the effect of the aqueous extract of Nauclea diderrichii. On intestine transit as on castor oil- and carbachol-induced motility, the aqueous and ethanolic extracts at doses of 100 and 200 mg/kg reduced significantly ( p < 0.05 , p < 0.01 , and p < 0.001 ) the travelled distance by charcoal and peristaltic index. Conclusions. The study demonstrated that the aqueous and ethanolic extracts of Nauclea diderrichii possess antisecretory and antispasmolytic properties hence its use in traditional medicine against diarrhea.

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Anti-inflammatory and anti-arthritic properties of aqueous extract of Nauclea diderrichii (Rubiaceae) stem bark in rats

Cited by 2 publications

References 40 publications

In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Antisecretory and Spasmolytic Activities of Aqueous and Ethanolic Stem Bark Extracts of Nauclea diderrichii in Wistar Rats

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