Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma

Lee, Mee-Young; Yuk, Ji-Eun; Kwon, Ok‐Kyoung; Kim, Hui‐Seong; Oh, Sei‐Ryang; Lee, Hyeong‐Kyu; Ahn, Ki Hoon

doi:10.1016/j.jep.2009.09.033

Cited by 26 publications

(15 citation statements)

References 29 publications

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“…The experimental results showed that the expression of HO-1 was significantly higher in the model than in the control group. Interestingly, similar results have been reported with extracts from plats close to those used in RN [32, 33]. …”

Section: Discussionsupporting

confidence: 84%

“…Several studies have focused on its immune-regulating properties, and RN has been shown to increase human lymphocyte proliferation, and immunoglobulin production in normal mice [31]. Plants related to those used in RN [32, 33] and other plants used in traditional Asiatic medicines [34–40] have been shown to have an effect on immunomodulation and inflammatory responses in experimental asthma. However, RN has not yet been investigated for application to allergic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐Inflammatory, Immunomodulatory, and Heme Oxygenase‐1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

Abdureyim

Amat

Umar

et al. 2010

Evidence-Based Complementary and Alternative Medicine

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Ravan Napas (RN) is a traditional formula used to treat pulmonary symptoms and diseases such as coughing, breathing difficulty, and asthma in traditional Uighur medicine. The purpose of this study was to investigate the anti-inflammatory, and immuno-modulatory activity of RN in a well-characterized animal model of allergic asthma. Rats were sensitized with intraperitoneal (ip) ovalbumin (OVA) and alum, and then challenged with OVA aerosols. The asthma model rats were treated with RN; saline- and dexamethasone- (DXM-) treated rats served as normal and model controls. The bronchoalveolar lavage fluid (BALF) cellular differential and the concentrations of sICAM-1, IL-4, IL-5, TNF-α, INF-γ, and IgE in serum were measured. Lung sections underwent histological analysis. The immunohistochemistry S-P method was used to measure the expression of ICAM-1 and HO-1 in the lung. RN significantly reduced the number of inflammatory cells in BALF and lung tissues, decreased sICAM-1, IL-4, IL-5, TNF-α, and IgE in serum, and increased serum INF-γ. There was a marked suppression of ICAM-1 and HO-1 expression in the lung. Our results suggest that RN may have an anti-inflammatory and immuneregulatory effect on allergic bronchial asthma by modulating the balance between Th1/Th2 cytokines.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory, Immunomodulatory, and Heme Oxygenase‐1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

Abdureyim

Amat

Umar

et al. 2010

Evidence-Based Complementary and Alternative Medicine

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“…It has traditionally been used because of its various pharmacological activities including diuretic, expectorant, and anti-inflammatory effects in conditions such as bronchitis, eczema, and skin eruptions [8]. Viola herbal extract is regarded to effectively clean blood components [9], and various studies show that V. mandshurica extract has potential anti-diabetic, anti-asthmatic, anti-oxidant, and neuroprotective activities [8, 10]. We previously showed that oral administration of V. mandshurica ethanolic extract (VME, 400 mg/kg/day) suppresses body weight and lipid accumulation in adipose tissue in mice [11].…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity activity, acute toxicity, and chemical constituents of aqueous and ethanol Viola mandshurica extracts

Sung

Kim

et al. 2017

BMC Complement Altern Med

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Background Viola mandshurica has traditionally been used as an expectorant, diuretic, and anti-inflammatory drug. The present study was designed to test the hypothesis that low doses of two different V. mandshurica extracts have anti-obesity effects.MethodsWe evaluated the effects of ethanol extract (VME) and aqueous extract (VMA) from V. mandshurica on high-fat diet (HFD)-induced obese mice as well as the acute oral toxicities and chemical compositions of both extracts.ResultsOral administration of VME or VMA (50, 100, or 200 mg/kg) decreased body weight gain, liver and adipose tissue mass, adipocyte size, and serum lipid levels. Both extracts increased adiponectin serum concentrations and mRNA expression in epididymal adipose tissue. VME and VMA also reversed the HFD-induced mRNA expression of lipogenic genes such as CCAAT/enhancer binding protein (C/EBP)α, C/EBPβ, sterol regulatory element-binding protein 1c, and leptin in adipose tissue, whereas they increased mRNA expression of uncoupling protein 2 and adenosine monophosphate-activated protein kinase (AMPK). VME and VMA increased the phosphorylation of AMPK and acetyl-coA carboxylase with a concomitant decrease in fat accumulation in the liver. High performance liquid chromatography analysis revealed that both VME and VMA contained esculetin (0.566% for VME, 0.231% for VMA) and schaftoside (0.147% for VME, 0.126% for VMA). In a 2-week acute toxicity study, administration of a single oral dose of VME or VMA (5000 mg/kg) caused no signs of toxicity or mortality.ConclusionsThese results suggest that both VM extracts exert anti-obesity effects in HFD-induced obese mice by suppressing lipogenesis and activating AMPK in the liver and adipose tissue. Our findings suggest that VM extracts could be a safe and effective treatment for obesity.

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“…5). The anti-asthmatic effect of the LI extract on lung tissues is similar to that of other herbs such as Duchesnea chrysantha and Viola mandshurica W. Becker as described in prior reports (Yang et al, 2008;Lee et al, 2010). To further understand the mechanism of inflammatory cell influx and mucus production, we investigated ROS production in BAL fluid cells.…”

Section: Resultsmentioning

confidence: 52%

Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice

Yang

Lee

Song

et al. 2011

Journal of Ethnopharmacology

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Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma

Cited by 26 publications

References 29 publications

Anti‐Inflammatory, Immunomodulatory, and Heme Oxygenase‐1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

Anti‐Inflammatory, Immunomodulatory, and Heme Oxygenase‐1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

Anti-obesity activity, acute toxicity, and chemical constituents of aqueous and ethanol Viola mandshurica extracts

Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice

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