Anti-inflammatory and anti-diabetic effects of brown seaweeds in high-fat diet-induced obese mice

Oh, Ji Hyun; Kim, Jae-Hoon; Lee, Yunkyoung

doi:10.4162/nrp.2016.10.1.42

Cited by 67 publications

(48 citation statements)

References 40 publications

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“…To prepare a zebrafish food containing 2.5% PM, we used gluten as a carrier material according to our previous study [ 30 ]. We decided on a PM dose of 2.5% ( w / w ) in zebrafish and mice experiments according to the dose used in other studies on algae-fed mice [ 31 , 32 ]. In addition, 1% ( w / w ) PM did not show any effect on body weight and blood chemistry in the zebrafish feeding experiment [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

et al. 2018

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(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases.

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Section: Methodsmentioning

confidence: 99%

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

et al. 2018

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“…A number of studies regarding the various health-promoting effects of brown seaweeds have been conducted in vitro and in vivo [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Brown seaweeds contain plenty of carbohydrates, essential amino acids, vitamins, and minerals.…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Effects and Anti-Inflammatory Effects of Laminaria japonica and Hizikia fusiforme in Skeletal Muscle: In Vitro and In Vivo Model

et al. 2018

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Laminaria japonica (LJ) and Hizikia fusiforme (HF) are brown seaweeds known to have various health-promoting effects. In this study, we investigated the anti-diabetic effects and possible mechanism(s) of LJ and HF by using both in vitro and in vivo models. C2C12 myotubes, mouse-derived skeletal muscle cells, treated with LF or HF extracts were used for the in vitro model, and muscle tissues from C57BL/6N mice fed a high-fat diet supplemented with 5% LF or HF for 16 weeks were used for the in vivo model. Although both the LF and HF extracts significantly inhibited α-glucosidase activity in a dose-dependent manner, the HF extract had a superior α-glucosidase inhibition than the LF extract. In addition, glucose uptake was significantly increased by LJ- and HF-treated groups when compared to the control group. Phosphorylation of protein kinase B and AMP-activated protein kinase was induced by LJ and HF in both the vivo and in vitro skeletal muscle models. Furthermore, LJ and HF significantly decreased tumor necrosis factor-α whereas both extracts increased interleukin (IL)-6 and IL-10 production in lipopolysaccharide-stimulated C2C12 myotubes. Taken together, these findings imply that the brown seaweeds LJ and HF could be useful therapeutic agents to attenuate muscle insulin resistance due to diet-induced obesity and its associated inflammation.

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“…It has been shown in vivo to have activity against cancer (Nakazawa et al 2009;Jaswir et al 2013), type II diabetes (Oh et al 2016), obesity (Maeda et al 2007), cholesterol (Beppu et al 2012), inflammatory disorders (Shiratori et al 2005), tumour angiogenesis (Martin 2015), malaria (Briglia et al 2015), hypertension (Sivagnanam et al 2015), and as a β-secretase 1 inhibitor in Alzheimer's disease (Jung et al 2016). Epidemiological data has suggested that the regular consumption of seaweeds can reduce the risk of developing diseases associated with oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Shannon¹,

Abu‐Ghannam²

2016

J Appl Phycol

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Fucoxanthin is a xanthophyll pigment which occurs in marine brown algae (Phaeophyceae). The anti-diabetic, anti-obesity, anti-cancer, and antioxidant properties of fucoxanthin have been widely reported. Macroalgae, particularly brown seaweeds, grow prolifically around Irish coasts, representing a valuable resource of nutraceuticals such as fucoxanthin for functional food applications. The aim of this study was to maximise the solvent extraction yield from three anatomically discrete regions of the seaweed thallus: blade, stipe, and holdfast. Response surface methodology was applied to determine optimum parameters for extraction of fucoxanthin from the seaweed, Fucus vesiculosus, as a model species. A central composite design was applied with four extraction variables: time (30-70 min), temperature (30-70°C), solvent pH (5.0-9.0), and percentage acetone (30-70 %). Fucoxanthin content of extracts was quantified by highperformance liquid chromatography. Percentage acetone was found to have the most significant (P = 0.0002) effect on fucoxanthin yield, followed by pH (P = 0.028) and temperature (P = 0.049). Multiple response optimisation determined that fucoxanthin yield from F. vesiculosus may be maximised by incubating at 30.0°C for 36.5 min, pH 5.7, with 62.2 % acetone. Optimised responses were applied to a further nine brown seaweeds; Alaria esculenta, Ascophyllum nodosum, Fucus serratus, Himanthalia elongata, Laminaria digitata, Laminaria hyperborea, Pelvetia canaliculata, Saccharina latissima, and Saccorhiza polyschides. In all species, the blades contained significantly more fucoxanthin than stipes, while holdfasts contained the least. Alaria esculenta blade had the greatest yield (0.870 mg g −1 dry mass), followed by ).

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Anti-inflammatory and anti-diabetic effects of brown seaweeds in high-fat diet-induced obese mice

Cited by 67 publications

References 40 publications

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Anti-Diabetic Effects and Anti-Inflammatory Effects of Laminaria japonica and Hizikia fusiforme in Skeletal Muscle: In Vitro and In Vivo Model

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

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